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SOD1 recombinant protein :: Cu/Zn Superoxide Dismutase Homodimer Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS197057 SOD1 recombinant protein
Unit / Price
0.02 mg  /  $195 +1 FREE 8GB USB
0.1 mg  /  $280 +1 FREE 8GB USB
1 mg  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cu/Zn Superoxide Dismutase Homodimer (SOD1), Recombinant Protein

 Also Known As   

Recombinant Human Cu/Zn Superoxide Dismutase Homodimer

 Product Gene Name   

SOD1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MATKAVCVLK GDGPVQGIIN FEQKESNGPV KVWGSIKGLT EGLHGFHVHE FGDNTAGCTS AGPHFNPLSR KHGGPKDEER HVGDLGNVTA DKDGVADVSI EDSVISLSGD HCIIGRTLVV HEKADDLGKG GNEESTKTGN
 Chromosome Location    Chromosome: 21; NC_000021.8 (33031935..33041244). Location: 21q22.1; 21q22.11
 OMIM    105400
 3D Structure    ModBase 3D Structure for P00441
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 Host    E Coli
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 Specificity    Human Cu/Zn Superoxide Dismutase Homodimer
 Purity/Purification    Greater than 95% as determined by SDS- PAGE and RPHPLC.
 Form/Format    Lyophilized white powder from a sterile-filtered solution (1mg/ml) in PBS, pH 7.4 Purified by proprietary chromatographic techniques.
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 Solubility    Reconstitute lyophilized product in sterile distilled H2O to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.
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 Preparation and Storage    Although lyophilized product is stable at room temperature for 3 weeks, it is best stored at or below -20 degree C. After reconstitution, product should be stored at or below -20 degree C. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.
 Other Notes    Small volumes of SOD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SOD1 recombinant protein

   Cu/Zn Superoxide Dismutase (SOD1) catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. It protects a cell from dangerous levels of superoxide. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals. Mutations in SOD1 cause a form of familial amyotrophic lateral sclerosis (ALS).

Recombinant Human Cu/Zn SOD1 produced in E. coli is a homodimer nonglycosylated polypeptide chain containing 2 x 154 amino acids with a molecular weight of 31.6kDa.
NCBI/Uniprot data below describe general gene information for SOD1. It may not necessarily be applicable to this product.
 NCBI GI #    4507149
 NCBI GeneID    6647
 NCBI Accession #    NP_000445.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000454.4 [Other Products]
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 UniProt Primary Accession #    P00441 [Other Products]
 UniProt Secondary Accession #    Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85; A6NHJ0; D3DSE4 [Other Products]
 UniProt Related Accession #    P00441 [Other Products]
 Molecular Weight    15,936 Da [Similar Products]
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 NCBI Official Full Name    superoxide dismutase
 NCBI Official Synonym Full Names    superoxide dismutase 1, soluble
 NCBI Official Symbol    SOD1 [Similar Products]
 NCBI Official Synonym Symbols   
ALS; SOD; ALS1; IPOA; hSod1; homodimer
[Similar Products]
 NCBI Protein Information    superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; SOD, soluble; OTTHUMP00000107278; OTTHUMP00000107279; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic
 UniProt Protein Name    Superoxide dismutase [Cu-Zn]
 UniProt Synonym Protein Names   
Superoxide dismutase 1
 Protein Family    Superoxide dismutase
 UniProt Gene Name    SOD1 [Similar Products]
 UniProt Entry Name    SODC_HUMAN
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 NCBI Summary for SOD1    The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq]
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 UniProt Comments for SOD1    SOD1: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family.

Protein type: Apoptosis; Oxidoreductase; Nuclear receptor co-regulator; EC 1.15.1.1; Mitochondrial

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: nucleoplasm; dendrite cytoplasm; extracellular matrix; extracellular space; protein complex; mitochondrion; cell soma; mitochondrial matrix; cytoplasm; extracellular region; plasma membrane; mitochondrial intermembrane space; peroxisome; cytoplasmic vesicle; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; copper ion binding; zinc ion binding; chaperone binding; superoxide dismutase activity; Rac GTPase binding; protein phosphatase 2B binding

Biological Process: positive regulation of catalytic activity; cellular iron ion homeostasis; activation of MAPK activity; positive regulation of apoptosis; myeloid cell homeostasis; retrograde axon cargo transport; muscle maintenance; response to antibiotic; retinal homeostasis; glutathione metabolic process; regulation of mitochondrial membrane potential; neurofilament cytoskeleton organization and biogenesis; positive regulation of superoxide release; negative regulation of neuron apoptosis; placenta development; response to drug; positive regulation of cytokine production; platelet activation; cell aging; transmission of nerve impulse; regulation of organ growth; response to reactive oxygen species; response to ethanol; heart contraction; response to heat; superoxide release; relaxation of vascular smooth muscle; removal of superoxide radicals; locomotory behavior; response to organic substance; platelet degranulation; sensory perception of sound; ovarian follicle development; regulation of blood pressure; response to axon injury; auditory receptor cell stereocilium organization and biogenesis; negative regulation of cholesterol biosynthetic process; anterograde axon cargo transport; response to nutrient levels; response to superoxide; thymus development; regulation of T cell differentiation in the thymus; response to amphetamine; superoxide metabolic process; myelin maintenance in the peripheral nervous system; regulation of multicellular organism growth; response to hydrogen peroxide; response to copper ion; spermatogenesis; blood coagulation; regulation of protein kinase activity; embryo implantation; hydrogen peroxide biosynthetic process

Disease: Amyotrophic Lateral Sclerosis 1
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 Research Articles on SOD1    1. structural instability and the resultant Cu-dependent pro-oxidant activity of the apo form of mutant SOD1 may be one of the pathogenic mechanisms of ALS
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SOD1 recombinant proteinPathways associated with SOD1 recombinant protein
 Reference Product  PubMed Publications
 CCS recombinant protein  >75 publications with SOD1 and CCS
 BCL2 recombinant protein  >13 publications with SOD1 and BCL2
 RNF19A recombinant protein  >4 publications with SOD1 and RNF19A
 KARS recombinant protein  >1 publications with SOD1 and KARS
 HOXB2 recombinant protein  >1 publications with SOD1 and HOXB2
 DNAJB1 recombinant protein  >1 publications with SOD1 and DNAJB1
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Oxidative Stress Pathway antibodies  Oxidative Stress Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
Diseases associated with SOD1 recombinant proteinOrgans/Tissues associated with SOD1 recombinant protein
 Disease Name  Pubmed Publications
 Amyotrophic Lateral Sclerosis Antibodies  >1679 publications with SOD1 and Amyotrophic Lateral Sclerosis
 Neurodegenerative Diseases Antibodies  >1583 publications with SOD1 and Neurodegenerative Diseases
 Nerve Degeneration Antibodies  >248 publications with SOD1 and Nerve Degeneration
 Cardiovascular Diseases Antibodies  >125 publications with SOD1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >121 publications with SOD1 and Vascular Diseases
 Dementia Antibodies  >107 publications with SOD1 and Dementia
 Neoplasms Antibodies  >107 publications with SOD1 and Neoplasms
 Inflammation Antibodies  >85 publications with SOD1 and Inflammation
 Mental Disorders Antibodies  >81 publications with SOD1 and Mental Disorders
 Brain Ischemia Antibodies  >65 publications with SOD1 and Brain Ischemia
 Organ/Tissue Name  Pubmed Publications
 Spinal Cord Antibodies  >772 publications with SOD1 and Spinal Cord
 Brain Antibodies  >603 publications with SOD1 and Brain
 Nerve Antibodies  >404 publications with SOD1 and Nerve
 Muscle Antibodies  >293 publications with SOD1 and Muscle
 Blood Antibodies  >269 publications with SOD1 and Blood
 Vascular Antibodies  >116 publications with SOD1 and Vascular
 Liver Antibodies  >115 publications with SOD1 and Liver
 Heart Antibodies  >54 publications with SOD1 and Heart
 Kidney Antibodies  >52 publications with SOD1 and Kidney
 Bone Antibodies  >42 publications with SOD1 and Bone
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