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Gak recombinant protein :: Cyclin-G-associated kinase (Gak), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958740 Gak recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,065 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,065 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,295 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,295 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,610 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,610 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,070 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,070 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,105 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $3,180 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cyclin-G-associated kinase (Gak), partial, Recombinant Protein

 Also Known As   

Recombinant Rat Cyclin-G-associated kinase (Gak), partial

 Product Synonym Names    Cyclin-G-associated kinase; EC=2.7.11.1
 Product Gene Name   

Gak recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    40-315, partial, provide the Protein kinase domain.
 Sequence    LRVRRVLAEG GFAFVYEAQD LGSGREYALK RLLSNEEEKN RAIIQEVCFL KKLSGHPNIV QFCSAASIGK EESDTGQAEF LLLTELCKGQ LVEFLRRVEC KGPLSCDSIL KIFYQTCRAV QHMHRQKPPI IHRDLKVENL LLSNQGTIKL CDFGSATTIS HYPDYSWSAQ KRAMVEEEIT RNTTPMYRTP EIVDLYSNFP IGEKQDIWAL GCILYLLCFR QHPFEDGAKL RIVNGKYSIP VNDTRYTVFH DLIRGMLKVN PEERLSIAEV VRQLQE
 3D Structure    ModBase 3D Structure for P97874
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Gak recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Gak recombinant protein

   In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the cyclin box. In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5.
NCBI/Uniprot data below describe general gene information for Gak. It may not necessarily be applicable to this product.
 NCBI GI #    13591947
 NCBI GeneID    81659
 NCBI Accession #    NP_112292.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031030.2 [Other Products]
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 UniProt Primary Accession #    P97874 [Other Products]
 UniProt Related Accession #    P97874 [Other Products]
 Molecular Weight    143,703 Da
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 NCBI Official Full Name    cyclin-G-associated kinase
 NCBI Official Synonym Full Names    cyclin G associated kinase
 NCBI Official Symbol    Gak [Similar Products]
 NCBI Protein Information    cyclin-G-associated kinase; cyclin G-associated kinase
 UniProt Protein Name    Cyclin-G-associated kinase
 Protein Family    Cyclin-G-associated kinase
 UniProt Gene Name    Gak [Similar Products]
 UniProt Entry Name    GAK_RAT
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 NCBI Summary for Gak    may be a serine/threonine protein kinase; may be involved with nucleotide metabolism [RGD, Feb 2006]
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 UniProt Comments for Gak    GAK: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Cell cycle regulation; Protein kinase, Other; Kinase, protein; Other group; NAK family

Cellular Component: Golgi apparatus; focal adhesion; membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm

Molecular Function: protein serine/threonine kinase activity; cyclin binding; ATP binding

Biological Process: endoplasmic reticulum organization and biogenesis; epidermal cell differentiation; forebrain morphogenesis; protein amino acid phosphorylation; cell development; Golgi organization and biogenesis
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 Research Articles on Gak    1. Early stages of clathrin-mediated endocytosis (CME) were partially inhibited when GAK expression was knocked down; GAK plays a role in clathrin-dependent trafficking from the trans Golgi network.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Gak recombinant proteinDiseases associated with Gak recombinant protein
 Reference Product  PubMed Publications
 Hip1r recombinant protein  >6 publications with Gak and Hip1r
 Hspa8 recombinant protein  >2 publications with Gak and Hspa8
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >44 publications with Gak and Nervous System Diseases
 Brain Diseases Antibodies  >30 publications with Gak and Brain Diseases
 Parkinson Disease Antibodies  >25 publications with Gak and Parkinson Disease
 Disease Models, Animal Antibodies  >7 publications with Gak and Disease Models, Animal
 Skin Diseases Antibodies  >6 publications with Gak and Skin Diseases
 Poisoning Antibodies  >4 publications with Gak and Poisoning
 Cardiovascular Diseases Antibodies  >4 publications with Gak and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >4 publications with Gak and Neoplasms, Experimental
 Liver Diseases Antibodies  >3 publications with Gak and Liver Diseases
 Atrophy Antibodies  >2 publications with Gak and Atrophy
Organs/Tissues associated with Gak recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with Gak and Brain
 Liver Antibodies  >16 publications with Gak and Liver
 Lung Antibodies  >12 publications with Gak and Lung
 Heart Antibodies  >7 publications with Gak and Heart
 Testis Antibodies  >6 publications with Gak and Testis
 Prostate Antibodies  >5 publications with Gak and Prostate
 Kidney Antibodies  >4 publications with Gak and Kidney
 Colon Antibodies  >2 publications with Gak and Colon
 Eye Antibodies  >2 publications with Gak and Eye
 Embryonic Tissue Antibodies  >2 publications with Gak and Embryonic Tissue
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