NP_066970.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,297 Da
NCBI Official Full Name
cyclin-O
NCBI Official Synonym Full Names
cyclin O
NCBI Protein Information
cyclin-O
UniProt Protein Name
Cyclin-O
NCBI Summary for CCNO
This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]
UniProt Comments for CCNO
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.
Research Articles on CCNO
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Products associated with CCNO recombinant protein
Pathways associated with CCNO recombinant protein
Diseases associated with CCNO recombinant protein
Organs/Tissues associated with CCNO recombinant protein
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