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CYPD recombinant protein :: Cyclophilin D (CYPD) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2018347 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $200 +1 FREE 8GB USB
0.05 mg  /  $440 +1 FREE 8GB USB
0.1 mg  /  $690 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cyclophilin D (CYPD), Recombinant Protein

 Also Known As   

Recombinant Cyclophilin D (CYPD)

 Product Gene Name   

CYPD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- AGKP SNSKNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGTGP TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGPNTNGS QFFITTVPTP HLDGKHVVFG QVIKGLGVAR MLENVEVNGE KPAKLCVIAE CGELKEGDEW G
 Chromosome Location    Chromosome: 2; NC_005101.3 (197690283..197702296). Location: 2q32
 3D Structure    ModBase 3D Structure for Q6DGG0
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Rattus norvegicus (Rat)
 Expression System    Prokaryotic expression
 Residues    Ala7~Gly191 (Accession # Q6DGG0) with two N-terminal Tags, His-tag and T7-tag
 Subcellular Location    Cytoplasm. Nucleus, nucleolus
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Predicted Isoelectric Point    6.9
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of CYPD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CYPD recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for CYPD recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of CYPD recombinant protein    CYPD recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CYPD. It may not necessarily be applicable to this product.
 NCBI GI #    51948528
 NCBI GeneID    361967
 NCBI Accession #    NP_001004279.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001004279.1 [Other Products]
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 UniProt Primary Accession #    Q6DGG0 [Other Products]
 UniProt Related Accession #    Q6DGG0 [Other Products]
 Molecular Weight    24.0kDa
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 NCBI Official Full Name    peptidyl-prolyl cis-trans isomerase D
 NCBI Official Synonym Full Names    peptidylprolyl isomerase D
 NCBI Official Symbol    Ppid [Similar Products]
 NCBI Official Synonym Symbols   
CypD; Cyp-40
[Similar Products]
 NCBI Protein Information    peptidyl-prolyl cis-trans isomerase D; PPIase D; rotamase D; Cyclophilin D; cyclophilin-40; 40 kDa peptidyl-prolyl cis-trans isomerase
 UniProt Protein Name    Peptidyl-prolyl cis-trans isomerase D
 UniProt Synonym Protein Names   
40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Rotamase D
 Protein Family    Cypemycin cysteine dehydrogenase
 UniProt Gene Name    Ppid [Similar Products]
 UniProt Synonym Gene Names    PPIase D; CYP-40 [Similar Products]
 UniProt Entry Name    PPID_RAT
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 UniProt Comments for CYPD    PPID: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.

Protein type: EC 5.2.1.8; Isomerase; Nucleolus

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; enzyme binding; heat shock protein binding; estrogen receptor binding; Hsp70 protein binding; Hsp90 protein binding; cyclosporin A binding; transcription factor binding

Biological Process: protein transport; protein peptidyl-prolyl isomerization; positive regulation of viral genome replication; regulation of mitochondrial membrane potential; positive regulation of protein secretion; protein folding; apoptosis; positive regulation of apoptosis; protein complex assembly; negative regulation of transcription from RNA polymerase II promoter; response to oxidative stress; negative regulation of apoptosis
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 Research Articles on CYPD    1. Ppid expression was predicted by plasma estradiol & 34% lower in control adolescent females than males. After chronic adolescent stress, females had elevated hippocampal Ppid expression that was not seen in males.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CYPD recombinant proteinDiseases associated with CYPD recombinant protein
 Products by Pathway  Pathway Diagram
 PKC-SCP2 Pathway antibodies  PKC-SCP2 Pathway Diagram
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >6 publications with CYPD and Disease Models, Animal
 Neoplasms Antibodies  >6 publications with CYPD and Neoplasms
 Necrosis Antibodies  >4 publications with CYPD and Necrosis
 Hyperplasia Antibodies  >3 publications with CYPD and Hyperplasia
 Fibrosis Antibodies  >2 publications with CYPD and Fibrosis
 Cardiovascular Diseases Antibodies  >2 publications with CYPD and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with CYPD and Hypertrophy
 Inflammation Antibodies  >2 publications with CYPD and Inflammation
 Weight Loss Antibodies  >2 publications with CYPD and Weight Loss
 Insulin Resistance Antibodies  >2 publications with CYPD and Insulin Resistance
Organs/Tissues associated with CYPD recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >35 publications with CYPD and Brain
 Muscle Antibodies  >5 publications with CYPD and Muscle
 Liver Antibodies  >3 publications with CYPD and Liver
 Lung Antibodies  >2 publications with CYPD and Lung
 Pancreas Antibodies  >1 publications with CYPD and Pancreas
 Prostate Antibodies  >1 publications with CYPD and Prostate
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