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CSE recombinant protein :: Cystathionine Gamma Lyase (CSE) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2018693 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $150 +1 FREE 8GB USB
0.05 mg  /  $290 +1 FREE 8GB USB
0.1 mg  /  $450 +1 FREE 8GB USB
0.2 mg  /  $560 +1 FREE 8GB USB
0.5 mg  /  $1,080 +1 FREE 8GB USB
1 mg  /  $1,605 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cystathionine Gamma Lyase (CSE), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Cystathionine Gamma Lyase (CSE)

 Product Gene Name   

CSE recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Cystathionine Gamma Lyase (CSE) (MBS2015730)
Antigen: Cystathionine Gamma Lyase (CSE) (MBS2018693)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000069.6 (157894248..157925081, complement). Location: 3 H4; 3
 3D Structure    ModBase 3D Structure for Q8VCN5
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 Host    E. coli
 Species Reactivity    Mouse
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 Purity/Purification    >98%
 Form/Format    20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
 Concentration    200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Phe14~Val224
 Tags    N-terminal His-Tag
 Tissue Specificity    Liver, Kidney
 Subcellular Location    Cytoplasm
 Traits    Freeze-dried powder
    
 Predicted isoelectric point    8.2
 Predicted Molecular Mass    26.7kDa
 Accurate Molecular Mass    27kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of CSE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for CSE recombinant protein   

SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.

(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of CSE recombinant protein    CSE recombinant protein Sequence image
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 SDS-PAGE of CSE recombinant protein    CSE recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for CSE. It may not necessarily be applicable to this product.
 NCBI GI #    22122387
 NCBI GeneID    107869
 NCBI Accession #    NP_666065.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_145953.2 [Other Products]
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 UniProt Primary Accession #    Q8VCN5 [Other Products]
 UniProt Secondary Accession #    Q6H324 [Other Products]
 UniProt Related Accession #    Q8VCN5 [Other Products]
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 NCBI Official Full Name    cystathionine gamma-lyase
 NCBI Official Synonym Full Names    cystathionase (cystathionine gamma-lyase)
 NCBI Official Symbol    Cth [Similar Products]
 NCBI Official Synonym Symbols   
CSE; Cys3; AI314617; BC019483; 0610010I13Rik
[Similar Products]
 NCBI Protein Information    cystathionine gamma-lyase; gamma-cystathionase; cysteine-protein sulfhydrase
 UniProt Protein Name    Cystathionine gamma-lyase
 UniProt Synonym Protein Names   
Cysteine-protein sulfhydrase; Gamma-cystathionase
 Protein Family    Caffeoylshikimate esterase
 UniProt Gene Name    Cth [Similar Products]
 UniProt Entry Name    CGL_MOUSE
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 UniProt Comments for CSE    CTH: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. Defects in CTH are the cause of cystathioninuria (CSTNU). It is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion. Belongs to the trans-sulfuration enzymes family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Other Amino Acids Metabolism - selenoamino acid; Cell cycle regulation; Energy Metabolism - nitrogen; Amino Acid Metabolism - cysteine and methionine; Lyase; EC 4.4.1.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: calmodulin binding; protein binding; cystathionine gamma-lyase activity; cystathionine beta-lyase activity; lyase activity; catalytic activity; pyridoxal phosphate binding

Biological Process: negative regulation of cell proliferation; glutathione metabolic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; cysteine biosynthetic process; homocysteine metabolic process; amino acid biosynthetic process; negative regulation of cell growth; negative regulation of apoptosis; activation of NF-kappaB transcription factor; protein homotetramerization
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 Research Articles on CSE    1. These results indicate that endogenous hydrogen sulfide generated by CSE plays a key proinflammatory role via NF-kappaB activation in caerulein-induced pancreatitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CSE recombinant proteinDiseases associated with CSE recombinant protein
 Products by Pathway  Pathway Diagram
 Amino Acid Metabolism Pathway antibodies  Amino Acid Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Formation From Homocysteine Pathway antibodies  Cysteine Formation From Homocysteine Pathway Diagram
 Degradation Of Cysteine And Homocysteine Pathway antibodies  Degradation Of Cysteine And Homocysteine Pathway Diagram
 Glutathione And One Carbon Metabolism Pathway antibodies  Glutathione And One Carbon Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >88 publications with CSE and Nervous System Diseases
 Brain Diseases Antibodies  >69 publications with CSE and Brain Diseases
 Cardiovascular Diseases Antibodies  >37 publications with CSE and Cardiovascular Diseases
 Neoplasms Antibodies  >36 publications with CSE and Neoplasms
 Immune System Diseases Antibodies  >19 publications with CSE and Immune System Diseases
 Carcinoma Antibodies  >12 publications with CSE and Carcinoma
 Death Antibodies  >10 publications with CSE and Death
 Hypertrophy Antibodies  >10 publications with CSE and Hypertrophy
 Atrophy Antibodies  >9 publications with CSE and Atrophy
 Heart Diseases Antibodies  >8 publications with CSE and Heart Diseases
Organs/Tissues associated with CSE recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >49 publications with CSE and Brain
 Kidney Antibodies  >16 publications with CSE and Kidney
 Liver Antibodies  >13 publications with CSE and Liver
 Testis Antibodies  >9 publications with CSE and Testis
 Eye Antibodies  >7 publications with CSE and Eye
 Lung Antibodies  >7 publications with CSE and Lung
 Thymus Antibodies  >5 publications with CSE and Thymus
 Embryonic Tissue Antibodies  >5 publications with CSE and Embryonic Tissue
 Pancreas Antibodies  >4 publications with CSE and Pancreas
 Skin Antibodies  >3 publications with CSE and Skin
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