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Cbs recombinant protein :: Cystathionine beta-synthase (Cbs) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1236288 Cbs recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $985 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,175 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,320 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,420 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,425 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,460 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,490 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,605 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,075 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,135 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,145 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,445 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,800 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cystathionine beta-synthase (Cbs), Recombinant Protein

 Also Known As   

Recombinant Rat Cystathionine beta-synthase (Cbs)

 Product Gene Name   

Cbs recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-561aa, Full Length of Mature Protein
 Sequence    PSGTSQCEDG SAGCPQDLEV QPEKGQLEKG ASGDKERVWI SPDTPSRCTW QLGRPMADSP HYHTVPTKSP KILPDILRKI GNTPMVRINR ISKNAGLKCE LLAKCEFFNA GGSVKDRISL RMIEDAERAG TLKPGDTIIE PTSGNTGIGL ALAAAVKGYR CIIVMPEKMS MEKVDVLRAL GAEIVRTPTN ARFDSPESHV GVAWRLKNEI PNSHILDQYR NASNPLAHYD DTAEEILQQC DGKVDMLVAS AGTGGTITGI ARKLKEKCPG CKIIGVDPEG SILAEPEELN QTEQTAYEVE GIGYDFIPTV LDRAVVDRWF KSNDDDSFAF ARMLISQEGL LCGGSSGSAM AVAVKAAQEL KEGQRCVVIL PDSVRNYMSK FLSDKWMLQK GFMKEELSVK RPWWWHLRVQ ELSLSAPLTV LPTVTCEHTI AILREKGFDQ APVVNESGAI LGMVTLGNML SSLLAGKVRP SDEVCKVLYK QFKPIHLTDT LGMLSHILEM DHFALVVHEQ IQSRDQAWSG VVGGPTDRNN GVSSKQLMVF GVVTAIDLLN FVAAREQTRK
 3D Structure    ModBase 3D Structure for P32232
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Cbs recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Cbs recombinant protein

   This protein acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria.
NCBI/Uniprot data below describe general gene information for Cbs. It may not necessarily be applicable to this product.
 NCBI GI #    158186659
 NCBI GeneID    24250
 NCBI Accession #    NP_036654.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012522.2 [Other Products]
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 UniProt Primary Accession #    P32232 [Other Products]
 UniProt Related Accession #    P32232 [Other Products]
 Molecular Weight    52,513 Da
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 NCBI Official Full Name    cystathionine beta-synthase
 NCBI Official Synonym Full Names    cystathionine beta synthase
 NCBI Official Symbol    Cbs [Similar Products]
 NCBI Protein Information    cystathionine beta-synthase
 UniProt Protein Name    Cystathionine beta-synthase
 UniProt Synonym Protein Names   
Beta-thionase; Hemoprotein H-450; Serine sulfhydrase
 Protein Family    Cystathionine beta-synthase
 UniProt Gene Name    Cbs [Similar Products]
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 NCBI Summary for Cbs    catalyzes condensation of serine and homocyteine to cystathione; involved in transsulfuration pathway; regulated by insulin; alternative splicing produces four mRNA species [RGD, Feb 2006]
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 UniProt Comments for Cbs    Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (PubMed:20149843, PubMed:8558235).
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 Research Articles on Cbs    1. We showed that astrocytes in Stroke-prone spontaneously hypertensive rats vulnerable to oxidative stress may be caused by reduction of H2S through lower expression and activity of CBS
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Cbs recombinant proteinPathways associated with Cbs recombinant protein
 Reference Product  PubMed Publications
 Mtr recombinant protein  >75 publications with Cbs and Mtr
 Bhmt recombinant protein  >35 publications with Cbs and Bhmt
 Shmt1 recombinant protein  >20 publications with Cbs and Shmt1
 Cth recombinant protein  >12 publications with Cbs and Cth
 Htt recombinant protein  >1 publications with Cbs and Htt
 Shmt2 recombinant protein  >1 publications with Cbs and Shmt2
 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway antibodies  Cysteine Biosynthesis, Homocysteine + Serine => Cysteine Pathway Diagram
 Cysteine Formation From Homocysteine Pathway antibodies  Cysteine Formation From Homocysteine Pathway Diagram
 Folic Acid Network Pathway antibodies  Folic Acid Network Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
Diseases associated with Cbs recombinant proteinOrgans/Tissues associated with Cbs recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >660 publications with Cbs and Nervous System Diseases
 Brain Diseases Antibodies  >439 publications with Cbs and Brain Diseases
 Hyperhomocysteinemia Antibodies  >328 publications with Cbs and Hyperhomocysteinemia
 Cardiovascular Diseases Antibodies  >317 publications with Cbs and Cardiovascular Diseases
 Neoplasms Antibodies  >206 publications with Cbs and Neoplasms
 Homocystinuria Antibodies  >174 publications with Cbs and Homocystinuria
 Malnutrition Antibodies  >156 publications with Cbs and Malnutrition
 Inflammation Antibodies  >91 publications with Cbs and Inflammation
 Hypertension Antibodies  >59 publications with Cbs and Hypertension
 Liver Diseases Antibodies  >57 publications with Cbs and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >874 publications with Cbs and Brain
 Liver Antibodies  >213 publications with Cbs and Liver
 Kidney Antibodies  >97 publications with Cbs and Kidney
 Adipose Tissue Antibodies  >29 publications with Cbs and Adipose Tissue
 Ovary Antibodies  >17 publications with Cbs and Ovary
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