NP_037072.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
61.9 kDa
NCBI Official Full Name
cytochrome P450 1B1
NCBI Official Synonym Full Names
cytochrome P450, family 1, subfamily b, polypeptide 1
NCBI Protein Information
cytochrome P450 1B1
UniProt Protein Name
Cytochrome P450 1B1
UniProt Synonym Protein Names
CYPIB1; Cytochrome P450RAP
UniProt Entry Name
CP1B1_RAT
NCBI Summary for Cyp1b1
plays a role in polycyclic aromatic hydrocarbon metabolism in adrenal microsomes [RGD, Feb 2006]
UniProt Comments for Cyp1b1
CYP1B1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Defects in CYP1B1 are the cause of primary congenital glaucoma type 3A (GLC3A). GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. Defects in CYP1B1 are a cause of primary open angle glaucoma (POAG). POAG is a complex and genetically heterogeneous ocular disorder characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. In some cases, POAG shows digenic inheritance involving mutations in CYP1B1 and MYOC genes. Defects in CYP1B1 are a cause of Peters anomaly (PAN). Peters anomaly is a congenital defect of the anterior chamber of the eye. Belongs to the cytochrome P450 family.
Protein type: Motility/polarity/chemotaxis; Oxidoreductase; Membrane protein, peripheral; Endoplasmic reticulum; Amino Acid Metabolism - tryptophan; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450
Cellular Component: endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle; mitochondrion; nucleus
Molecular Function: heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Biological Process: adrenal gland development; angiogenesis; arachidonic acid metabolic process; aromatic compound metabolic process; benzene and derivative metabolic process; blood vessel morphogenesis; cell adhesion; collagen fibril organization; dibenzo-p-dioxin metabolic process; DNA modification; endothelial cell migration; estrogen metabolic process; induction of apoptosis by oxidative stress; inhibition of NF-kappaB transcription factor; male gonad development; membrane lipid catabolic process; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; negative regulation of cell proliferation; nitric oxide biosynthetic process; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell migration; positive regulation of translation; response to arsenic; response to estradiol stimulus; response to follicle-stimulating hormone stimulus; response to nutrient; response to organic cyclic substance; response to organic substance; response to steroid hormone stimulus; response to toxin; retinal metabolic process; retinol metabolic process; steroid metabolic process; toxin metabolic process; xenobiotic metabolic process
Product References and Citations for Cyp1b1 recombinant protein
"Specificity determinants of CYP1B1 estradiol hydroxylation."
Nishida C.R., Everett S., Ortiz de Montellano P.R.
Mol. Pharmacol. 84:451-458(2013)
Research Articles on Cyp1b1
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Products associated with Cyp1b1 recombinant protein
Pathways associated with Cyp1b1 recombinant protein
Diseases associated with Cyp1b1 recombinant protein
Organs/Tissues associated with Cyp1b1 recombinant protein
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