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CYP2B6 recombinant protein :: Cytochrome P450 2B6 (CYP2B6) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967684 CYP2B6 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $910 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,120 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,220 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,340 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,345 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,370 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,420 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,515 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,915 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,035 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,065 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,310 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,680 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 2B6 (CYP2B6), Recombinant Protein

 Also Known As   

Recombinant Human Cytochrome P450 2B6 (CYP2B6)

 Product Synonym Names    Cytochrome P450 2B6; EC=1.14.14.1; CYPIIB6; Cytochrome P450 IIB1
 Product Gene Name   

CYP2B6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-491aa; Full length protein
 Sequence    MELSVLLFLA LLTGLLLLLV QRHPNTHDRL PPGPRPLPLL GNLLQMDRRG LLKSFLRFRE KYGDVFTVHL GPRPVVMLCG VEAIREALVD KAEAFSGRGK IAMVDPFFRG YGVIFANGNR WKVLRRFSVT TMRDFGMGKR SVEERIQEEA QCLIEELRKS KGALMDPTFL FQSITANIIC SIVFGKRFHY QDQEFLKMLN LFYQTFSLIS SVFGQLFELF SGFLKYFPGA HRQVYKNLQE INAYIGHSVE KHRETLDPSA PKDLIDTYLL HMEKEKSNAH SEFSHQNLNL NTLSLFFAGT ETTSTTLRYG FLLMLKYPHV AERVYREIEQ VIGPHRPPEL HDRAKMPYTE AVIYEIQRFS DLLPMGVPHI VTQHTSFRGY IIPKDTEVFL ILSTALHDPH YFEKPDAFNP DHFLDANGAL KKTEAFIPFS LGKRICLGEG IARAELFLFF TTILQNFSMA SPVAPEDIDL TPQECGVGKI PPTYQIRFLP R
 OMIM    gene 614546
 3D Structure    ModBase 3D Structure for P20813
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CYP2B6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CYP2B6 recombinant protein

   This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
NCBI/Uniprot data below describe general gene information for CYP2B6. It may not necessarily be applicable to this product.
 NCBI GI #    7949031
 NCBI GeneID    1555
 NCBI Accession #    NP_000758.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000767.4 [Other Products]
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 UniProt Primary Accession #    P20813 [Other Products]
 UniProt Secondary Accession #    Q2V565; Q9UK46; B4DWP3 [Other Products]
 UniProt Related Accession #    P20813 [Other Products]
 Molecular Weight    33,385 Da
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 NCBI Official Full Name    cytochrome P450 2B6
 NCBI Official Synonym Full Names    cytochrome P450, family 2, subfamily B, polypeptide 6
 NCBI Official Symbol    CYP2B6 [Similar Products]
 NCBI Official Synonym Symbols   
CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6
[Similar Products]
 NCBI Protein Information    cytochrome P450 2B6; cytochrome P450 IIB1; 1,4-cineole 2-exo-monooxygenase; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
 UniProt Protein Name    Cytochrome P450 2B6
 UniProt Synonym Protein Names   
1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1
 Protein Family    Cytochrome
 UniProt Gene Name    CYP2B6 [Similar Products]
 UniProt Entry Name    CP2B6_HUMAN
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 NCBI Summary for CYP2B6    This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CYP2B6    CYP2B6: cytochrome P450, subfamily IIB. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Phosphorylation is accompanied by a decrease in enzyme activity.

Protein type: Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - arachidonic acid; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm

Molecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity

Biological Process: steroid metabolic process; ketone metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway; drug metabolic process

Disease: Efavirenz, Poor Metabolism Of
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 Research Articles on CYP2B6    1. CYP2B6 gene polymorphism G15631T has an effect on imatinib response in Moroccan chronic myeloid leukemia patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CYP2B6 recombinant proteinPathways associated with CYP2B6 recombinant protein
 Reference Product  PubMed Publications
 UGT1A1 recombinant protein  >41 publications with CYP2B6 and UGT1A1
 UGT1A9 recombinant protein  >17 publications with CYP2B6 and UGT1A9
 GSTA1 recombinant protein  >16 publications with CYP2B6 and GSTA1
 GSTA2 recombinant protein  >5 publications with CYP2B6 and GSTA2
 UGT1A4 recombinant protein  >4 publications with CYP2B6 and UGT1A4
 UGT1A7 recombinant protein  >2 publications with CYP2B6 and UGT1A7
 GSTA4 recombinant protein  >1 publications with CYP2B6 and GSTA4
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 CYP2E1 Reactions Pathway antibodies  CYP2E1 Reactions Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Fatty Acids Pathway antibodies  Fatty Acids Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
Diseases associated with CYP2B6 recombinant proteinOrgans/Tissues associated with CYP2B6 recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >67 publications with CYP2B6 and Liver Diseases
 Liver Neoplasms Antibodies  >37 publications with CYP2B6 and Liver Neoplasms
 Mental Disorders Antibodies  >36 publications with CYP2B6 and Mental Disorders
 Nervous System Diseases Antibodies  >32 publications with CYP2B6 and Nervous System Diseases
 Poisoning Antibodies  >27 publications with CYP2B6 and Poisoning
 Drug-Related Side Effects and Adverse Reactions Antibodies  >25 publications with CYP2B6 and Drug-Related Side Effects and Adverse Reactions
 Carcinoma, Hepatocellular Antibodies  >21 publications with CYP2B6 and Carcinoma, Hepatocellular
 Drug-Induced Liver Injury Antibodies  >16 publications with CYP2B6 and Drug-Induced Liver Injury
 Hepatitis Antibodies  >16 publications with CYP2B6 and Hepatitis
 Kidney Diseases Antibodies  >14 publications with CYP2B6 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >671 publications with CYP2B6 and Liver
 Kidney Antibodies  >39 publications with CYP2B6 and Kidney
 Intestine Antibodies  >25 publications with CYP2B6 and Intestine
 Muscle Antibodies  >5 publications with CYP2B6 and Muscle
 Mammary Gland Antibodies  >1 publications with CYP2B6 and Mammary Gland
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