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CYP2C8 recombinant protein :: Cytochrome P450 2C8 (CYP2C8) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS949831 CYP2C8 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $910 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,120 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,220 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,340 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,345 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,370 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,420 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,515 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,915 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,035 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,065 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,305 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,680 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytochrome P450 2C8 (CYP2C8), Recombinant Protein

 Also Known As   

Recombinant Human Cytochrome P450 2C8 (CYP2C8)

 Product Gene Name   

CYP2C8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-490aa, Full length protein
 Sequence    MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP PSYQICFIPV
 OMIM    601129
 3D Structure    ModBase 3D Structure for P10632
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CYP2C8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CYP2C8 recombinant protein

   This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
NCBI/Uniprot data below describe general gene information for CYP2C8. It may not necessarily be applicable to this product.
 NCBI GI #    98991773
 NCBI GeneID    1558
 NCBI Accession #    NP_000761.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000770.3 [Other Products]
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 UniProt Primary Accession #    P10632 [Other Products]
 UniProt Secondary Accession #    Q5VX93; Q8WWB1; Q9UCZ9; A8K9N8; B0AZN2; B7Z1F6 [Other Products]
 UniProt Related Accession #    P10632 [Other Products]
 Molecular Weight    44,358 Da
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 NCBI Official Full Name    cytochrome P450 2C8 isoform a
 NCBI Official Synonym Full Names    cytochrome P450 family 2 subfamily C member 8
 NCBI Official Symbol    CYP2C8 [Similar Products]
 NCBI Official Synonym Symbols   
CPC8; CYPIIC8; MP-12/MP-20
[Similar Products]
 NCBI Protein Information    cytochrome P450 2C8
 UniProt Protein Name    Cytochrome P450 2C8
 UniProt Synonym Protein Names   
CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase
 Protein Family    Cytochrome
 UniProt Gene Name    CYP2C8 [Similar Products]
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 NCBI Summary for CYP2C8    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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 UniProt Comments for CYP2C8    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol).
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 Research Articles on CYP2C8    1. We found that SNPs rs7909236 and rs1934953 of the CYP2C8 gene were significantly associated with increased risk of essential hypertension.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CYP2C8 recombinant proteinPathways associated with CYP2C8 recombinant protein
 Reference Product  PubMed Publications
 UGT1A1 recombinant protein  >21 publications with CYP2C8 and UGT1A1
 UGT1A9 recombinant protein  >13 publications with CYP2C8 and UGT1A9
 UGT2B7 recombinant protein  >11 publications with CYP2C8 and UGT2B7
 UGT1A3 recombinant protein  >9 publications with CYP2C8 and UGT1A3
 UGT1A6 recombinant protein  >6 publications with CYP2C8 and UGT1A6
 UGT1A8 recombinant protein  >3 publications with CYP2C8 and UGT1A8
 UGT1A7 recombinant protein  >2 publications with CYP2C8 and UGT1A7
 UGT1A4 recombinant protein  >2 publications with CYP2C8 and UGT1A4
 EPHX2 recombinant protein  >2 publications with CYP2C8 and EPHX2
 Products by Pathway  Pathway Diagram
 Arachidonate Epoxygenase / Epoxide Hydrolase Pathway antibodies  Arachidonate Epoxygenase / Epoxide Hydrolase Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 CYP2E1 Reactions Pathway antibodies  CYP2E1 Reactions Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
Diseases associated with CYP2C8 recombinant proteinOrgans/Tissues associated with CYP2C8 recombinant protein
 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >62 publications with CYP2C8 and Drug Toxicity
 Liver Diseases Antibodies  >25 publications with CYP2C8 and Liver Diseases
 Fatty Liver Antibodies  >17 publications with CYP2C8 and Fatty Liver
 Hypertension Antibodies  >17 publications with CYP2C8 and Hypertension
 Nervous System Diseases Antibodies  >17 publications with CYP2C8 and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >14 publications with CYP2C8 and Gastrointestinal Diseases
 Heart Diseases Antibodies  >13 publications with CYP2C8 and Heart Diseases
 Rhabdomyolysis Antibodies  >11 publications with CYP2C8 and Rhabdomyolysis
 Necrosis Antibodies  >10 publications with CYP2C8 and Necrosis
 Brain Diseases Antibodies  >8 publications with CYP2C8 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >456 publications with CYP2C8 and Liver
 Kidney Antibodies  >37 publications with CYP2C8 and Kidney
 Brain Antibodies  >8 publications with CYP2C8 and Brain
 Prostate Antibodies  >8 publications with CYP2C8 and Prostate
 Stomach Antibodies  >6 publications with CYP2C8 and Stomach
 Uterus Antibodies  >5 publications with CYP2C8 and Uterus
 Testis Antibodies  >4 publications with CYP2C8 and Testis
 Connective Tissue Antibodies  >2 publications with CYP2C8 and Connective Tissue
 Mouth Antibodies  >2 publications with CYP2C8 and Mouth
 Eye Antibodies  >2 publications with CYP2C8 and Eye
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