NP_031833.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
65,305 Da
NCBI Official Full Name
cytochrome b-245 heavy chain
NCBI Official Synonym Full Names
cytochrome b-245, beta polypeptide
NCBI Official Synonym Symbols
Cgd; Cyd; Nox2; C88302; gp91-1; gp91phox; CGD91-phox [Similar Products]
NCBI Protein Information
cytochrome b-245 heavy chain
UniProt Protein Name
Cytochrome b-245 heavy chain
UniProt Synonym Protein Names
CGD91-phox; Cytochrome b(558) subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; Neutrophil cytochrome b 91 kDa polypeptide; gp91-1; gp91-phox; p22 phagocyte B-cytochrome
UniProt Synonym Gene Names
UniProt Entry Name
CY24B_MOUSE
NCBI Summary for Cybb
This gene encodes the heavy chain component of a heterodimeric transmembrane ion transporter composed of both a heavy and a light chain. This transporter mediates the transfer of electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to oxygen to generate superoxide. This reaction is important in the innate immune response to pathogens. However, increased activity of the encoded protein also leads to the generation of reactive oxygen species that result in oxidative stress and can cause tissue damage. Conversely, loss of function of the related gene in human causes chronic granulomatous disease. Alternative splicing results in multiple transcript variants, although the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
UniProt Comments for Cybb
CYBB: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of granulomatous disease,chronic, X-linked (CGD). A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life- threatening bacterial/fungal infections. Defects in CYBB are a cause of mycobacteriosis atypical X-linked type 2 (AMCBX2). A rare condition characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections.
Protein type: EC 1.-.-.-; Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass; Oxidoreductase
Cellular Component: cell soma; cytoplasm; dendrite; endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; intracellular; membrane; mitochondrion; NADPH oxidase complex; nuclear envelope; perinuclear region of cytoplasm; plasma membrane; rough endoplasmic reticulum
Molecular Function: electron carrier activity; F420H2 dehydrogenase activity; FAD binding; heme binding; malolactic enzyme activity; metal ion binding; N-ethylmaleimide reductase activity; oxidoreductase activity; protein binding; protein heterodimerization activity; sulfur oxygenase reductase activity; superoxide-generating NADPH oxidase activity; voltage-gated ion channel activity
Biological Process: hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; ion transport; positive regulation of angiogenesis; positive regulation of tumor necrosis factor biosynthetic process; respiratory burst; response to drug; superoxide metabolic process; superoxide release; transport
Research Articles on Cybb
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Products associated with Cybb recombinant protein
Pathways associated with Cybb recombinant protein
Diseases associated with Cybb recombinant protein
Organs/Tissues associated with Cybb recombinant protein
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