AAH38713.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,489 Da
NCBI Official Full Name
Cytohesin 2
NCBI Official Synonym Full Names
cytohesin 2
NCBI Official Synonym Symbols
ARNO; CTS18; PSCD2; SEC7L; PSCD2L; CTS18.1; Sec7p-L; Sec7p-like [Similar Products]
NCBI Protein Information
cytohesin-2
UniProt Protein Name
Cytohesin-2
UniProt Synonym Protein Names
ARF exchange factor; ARF nucleotide-binding site opener; Protein ARNO; PH, SEC7 and coiled-coil domain-containing protein 2
UniProt Synonym Gene Names
UniProt Entry Name
CYH2_HUMAN
NCBI Summary for CYTH2
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for CYTH2
cytohesin 2: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, ARF
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: membrane; cytoplasm; plasma membrane; trans-Golgi network
Molecular Function: protein binding; lipid binding; ARF guanyl-nucleotide exchange factor activity
Biological Process: regulation of cell adhesion; vesicle-mediated transport; endocytosis; regulation of ARF protein signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity
Research Articles on CYTH2
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Products associated with CYTH2 recombinant protein
Pathways associated with CYTH2 recombinant protein
Diseases associated with CYTH2 recombinant protein
Organs/Tissues associated with CYTH2 recombinant protein
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