NP_001177725.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cytoplasmic protein NCK1 isoform 2
NCBI Official Synonym Full Names
NCK adaptor protein 1
NCBI Protein Information
cytoplasmic protein NCK1
UniProt Protein Name
Cytoplasmic protein NCK1
UniProt Synonym Protein Names
NCK adaptor protein 1; Nck-1; SH2/SH3 adaptor protein NCK-alpha
UniProt Synonym Gene Names
NCBI Summary for NCK1
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
UniProt Comments for NCK1
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.
Research Articles on NCK1
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Products associated with NCK1 recombinant protein
Pathways associated with NCK1 recombinant protein
Diseases associated with NCK1 recombinant protein
Organs/Tissues associated with NCK1 recombinant protein
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