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CTLA4 recombinant protein :: Cytotoxic T-lymphocyte protein 4 (CTLA4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS963818 CTLA4 recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cytotoxic T-lymphocyte protein 4 (CTLA4), Recombinant Protein

 Also Known As   

Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4)

 Product Synonym Names    Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD_antigen=; CD152
 Product Gene Name   

CTLA4 recombinant protein

[Similar Products]
 Product Synonym Gene Name    CTLA4; CD152 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    36-161
 Sequence    KAMHV AQPAVVLASS RGIASFVCEY ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD SICTGTSSGN QVNLTIQGLR AMDTGLYICK VELMYPPPYY LGIGNGTQIY VIDPEPCPDS D
 OMIM    610424
 3D Structure    ModBase 3D Structure for P16410
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CTLA4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CTLA4. It may not necessarily be applicable to this product.
 NCBI GI #    83700231
 NCBI GeneID    1493
 NCBI Accession #    NP_001032720.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001037631.2 [Other Products]
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 UniProt Primary Accession #    P16410 [Other Products]
 UniProt Secondary Accession #    O95653; Q0PP65; Q52MC1; Q53TD5; Q5S005; Q8WXJ1; Q96P43; Q9UKN9; A0N1S0; E9PDH0 [Other Products]
 UniProt Related Accession #    P16410 [Other Products]
 Molecular Weight    19,145 Da
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 NCBI Official Full Name    cytotoxic T-lymphocyte protein 4 isoform CTLA-4delTM
 NCBI Official Synonym Full Names    cytotoxic T-lymphocyte-associated protein 4
 NCBI Official Symbol    CTLA4 [Similar Products]
 NCBI Official Synonym Symbols   
CD; GSE; GRD4; CD152; CTLA-4; IDDM12; CELIAC3
[Similar Products]
 NCBI Protein Information    cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; insulin-dependent diabetes mellitus 12; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
 UniProt Protein Name    Cytotoxic T-lymphocyte protein 4
 UniProt Synonym Protein Names   
Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD_antigen: CD152
 Protein Family    Cytotoxic T-lymphocyte protein
 UniProt Gene Name    CTLA4 [Similar Products]
 UniProt Synonym Gene Names    CD152; CTLA-4 [Similar Products]
 UniProt Entry Name    CTLA4_HUMAN
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 NCBI Summary for CTLA4    This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CTLA4    CTLA-4: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; clathrin-coated endocytic vesicle; external side of plasma membrane

Molecular Function: protein binding

Biological Process: B cell receptor signaling pathway; negative regulation of T cell proliferation; negative regulation of regulatory T cell differentiation; positive regulation of apoptosis; T cell costimulation; negative regulation of immune response; immune response; negative regulation of B cell proliferation; response to DNA damage stimulus

Disease: Autoimmune Lymphoproliferative Syndrome, Type V; Celiac Disease, Susceptibility To, 3; Diabetes Mellitus, Insulin-dependent, 12; Systemic Lupus Erythematosus; Hashimoto Thyroiditis
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 Research Articles on CTLA4    1. A CTLA-4 polymorphism is involved in the pathogenesis of ANCA-associated vasculitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CTLA4 recombinant proteinPathways associated with CTLA4 recombinant protein
 Reference Product  PubMed Publications
 CD80 recombinant protein  >976 publications with CTLA4 and CD80
 CD86 recombinant protein  >620 publications with CTLA4 and CD86
 FOXP3 recombinant protein  >535 publications with CTLA4 and FOXP3
 LCK recombinant protein  >18 publications with CTLA4 and LCK
 PTPN11 recombinant protein  >13 publications with CTLA4 and PTPN11
 CD276 recombinant protein  >9 publications with CTLA4 and CD276
 FYN recombinant protein  >7 publications with CTLA4 and FYN
 LYN recombinant protein  >4 publications with CTLA4 and LYN
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
Diseases associated with CTLA4 recombinant proteinOrgans/Tissues associated with CTLA4 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >805 publications with CTLA4 and Neoplasms
 Melanoma Antibodies  >396 publications with CTLA4 and Melanoma
 Necrosis Antibodies  >339 publications with CTLA4 and Necrosis
 Inflammation Antibodies  >329 publications with CTLA4 and Inflammation
 Arthritis, Rheumatoid Antibodies  >206 publications with CTLA4 and Arthritis, Rheumatoid
 Graves Disease Antibodies  >167 publications with CTLA4 and Graves Disease
 Carcinoma Antibodies  >148 publications with CTLA4 and Carcinoma
 Neoplasms, Experimental Antibodies  >132 publications with CTLA4 and Neoplasms, Experimental
 Liver Diseases Antibodies  >131 publications with CTLA4 and Liver Diseases
 Lymphoma Antibodies  >78 publications with CTLA4 and Lymphoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2910 publications with CTLA4 and Blood
 Lymph Node Antibodies  >227 publications with CTLA4 and Lymph Node
 Kidney Antibodies  >181 publications with CTLA4 and Kidney
 Lung Antibodies  >168 publications with CTLA4 and Lung
 Prostate Antibodies  >68 publications with CTLA4 and Prostate
 Mammary Gland Antibodies  >1 publications with CTLA4 and Mammary Gland
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