NP_036679.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
D(2) dopamine receptor
NCBI Official Synonym Full Names
dopamine receptor D2
NCBI Protein Information
D(2) dopamine receptor; D(2) dopamine receptor; dopamine receptor 2
UniProt Protein Name
D(2) dopamine receptor
UniProt Synonym Protein Names
Dopamine D2 receptor
UniProt Entry Name
DRD2_RAT
NCBI Summary for Drd2
mediates G-protein coupled signaling; may be involved in movement disorders, schizophrenia, and drug addiction [RGD, Feb 2006]
UniProt Comments for Drd2
DRD2: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Defects in DRD2 are associated with dystonia type 11 (DYT11); also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1
Cellular Component: synaptic vesicle membrane; integral to plasma membrane; postsynaptic density; dendrite; acrosome; dendritic spine; perikaryon; membrane; endocytic vesicle; axon; plasma membrane; nerve terminal; cytoplasmic vesicle; lateral plasma membrane
Molecular Function: dopamine D2 receptor-like receptor activity; G-protein coupled receptor activity; ionotropic glutamate receptor binding; identical protein binding; protein binding; protein homodimerization activity; dopamine receptor activity; protein heterodimerization activity; dopamine binding; drug binding; receptor binding
Biological Process: response to nicotine; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); prepulse inhibition; positive regulation of dopamine uptake; response to toxin; positive regulation of receptor internalization; positive regulation of multicellular organism growth; regulation of phosphoprotein phosphatase activity; thermoregulation; adult walking behavior; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; negative regulation of insulin secretion; protein localization; phosphatidylinositol metabolic process; negative regulation of blood pressure; response to drug; response to inactivity; positive regulation of neuroblast proliferation; response to light stimulus; cerebral cortex GABAergic interneuron migration; positive regulation of mitosis; negative regulation of synaptic transmission, glutamatergic; regulation of sodium ion transport; arachidonic acid secretion; regulation of synaptic transmission, GABAergic; G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of growth hormone secretion; acid secretion; response to ethanol; G-protein coupled receptor internalization; reduction of cytosolic calcium ion concentration; regulation of MAPKKK cascade; dopamine receptor signaling pathway; activation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of long-term neuronal synaptic plasticity; synaptic transmission, dopaminergic; peristalsis; startle response; branching morphogenesis of a nerve; negative regulation of circadian sleep/wake cycle, sleep; response to morphine; locomotory behavior; behavioral response to ethanol; orbitofrontal cortex development; cellular potassium ion homeostasis; regulation of dopamine secretion; negative regulation of cell proliferation; synaptic transmission; synaptogenesis; behavioral response to cocaine; forebrain development; visual learning; adenohypophysis development; feeding behavior; nerve-nerve synaptic transmission; response to axon injury; circadian regulation of gene expression; negative regulation of dopamine secretion; response to iron ion; negative regulation of cell migration; associative learning; positive regulation of cytokinesis; grooming behavior; regulation of synaptic transmission; negative regulation of protein secretion; Wnt receptor signaling pathway; negative regulation of protein kinase B signaling cascade; striatum development; regulation of cAMP metabolic process; regulation of potassium ion transport; regulation of heart rate; negative regulation of adenylate cyclase activity; response to amphetamine; sensory perception of smell; regulation of dopamine uptake; auditory behavior; response to cocaine; G-protein coupled receptor protein signaling pathway; regulation of systemic arterial blood pressure by neurological process; negative regulation of dopamine receptor signaling pathway; pigmentation; axonogenesis; long-term memory; release of sequestered calcium ion into cytosol; adult behavior; positive regulation of G-protein coupled receptor protein signaling pathway; response to hypoxia; regulation of synapse structural plasticity; dopamine receptor, phospholipase C activating pathway
Research Articles on Drd2
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Pathways associated with Drd2 recombinant protein
Diseases associated with Drd2 recombinant protein
Organs/Tissues associated with Drd2 recombinant protein
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