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D2hgdh recombinant protein :: D-2-hydroxyglutarate dehydrogenase, mitochondrial (D2hgdh) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1337335 D2hgdh recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,270 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,270 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,490 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,490 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,075 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,075 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,540 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,540 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

D-2-hydroxyglutarate dehydrogenase, mitochondrial (D2hgdh), Recombinant Protein

 Also Known As   

Recombinant Mouse D-2-hydroxyglutarate dehydrogenase, mitochondrial (D2hgdh)

 Product Synonym Names    D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC=1.1.99.-
 Product Gene Name   

D2hgdh recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    51-535
 Sequence    SVVAGGPEVT LTPERYPVQR LPFSTVSEED LAAFECIIPG RVITDPEQLQ TCNVDWLKTV RGCSKVLLRP QTSEEVSQIL RHCYKRNLAV NPQGGNTGMV GGSVPVFDEV ILSTALMNQV ISFHDVSGIL VCQAGCVLEE LSRYVQERDF IMPLDLGAKG SCHIGGNVAT NAGGLRFLRY GSLRGTVLGL EVVLADGTIL NCLTSLRKDN TGYDLKQMFI GSEGTLGVIT AVSIVCPPRP KAVNVAFLGC PGFAEVLQTF RTCRGMLGEI LSAFEFMDTE CMQLVGQHLQ LTNPVQESPF YVLVETSGSS AGHDAEKLTN VLEQVLNSGL VTDGTMATDQ RKVQMLWALR ERITEALSRD GYVFKYDLSL PVERLYDLVI DLRTRLGPRA KHVVGYGHLG DGNLHLNVTA EAFSRELLGA LEPYVYAWTA EQRGSVSAEH GLGFKKKDVL GYSKPPVAVT LMQQLKAMLD PEGILNPYKT LPAQA
 3D Structure    ModBase 3D Structure for Q8CIM3
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of D2hgdh recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for D2hgdh. It may not necessarily be applicable to this product.
 NCBI GI #    170014723
 NCBI GeneID    98314
 NCBI Accession #    NP_849213.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_178882.3 [Other Products]
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 UniProt Primary Accession #    Q8CIM3 [Other Products]
 UniProt Secondary Accession #    Q149H0; Q3TDF5; Q8BU06; E9QLL1 [Other Products]
 UniProt Related Accession #    Q8CIM3 [Other Products]
 Molecular Weight    58,576 Da
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 NCBI Official Full Name    D-2-hydroxyglutarate dehydrogenase, mitochondrial
 NCBI Official Synonym Full Names    D-2-hydroxyglutarate dehydrogenase
 NCBI Official Symbol    D2hgdh [Similar Products]
 NCBI Official Synonym Symbols   
AA408776; AA408778; AI325464
[Similar Products]
 NCBI Protein Information    D-2-hydroxyglutarate dehydrogenase, mitochondrial
 UniProt Protein Name    D-2-hydroxyglutarate dehydrogenase, mitochondrial
 Protein Family    D-2-hydroxyglutarate dehydrogenase
 UniProt Gene Name    D2hgdh [Similar Products]
 UniProt Entry Name    D2HDH_MOUSE
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 UniProt Comments for D2hgdh    D2HGDH: an oxidoreductase that act on the CH-OH group of donor with other acceptors. Catalyzes the oxidation of D-2-hydroxyglutarate (2HG) to alpha-ketoglutarate. Belongs to the FAD-binding oxidoreductase/transferase type 4 family. 2 human isoforms produced by alternative splicing. Defects in D2HGDH are the cause of D-2-hydroxyglutaric aciduria (D2HGA), a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.

Protein type: Mitochondrial; Oxidoreductase; EC 1.1.99.-

Cellular Component: mitochondrion

Molecular Function: UDP-N-acetylmuramate dehydrogenase activity; limonene-1,2-diol dehydrogenase activity; FAD binding; (R)-2-hydroxyglutarate dehydrogenase activity; oxidoreductase activity; catalytic activity; oxidoreductase activity, acting on CH-OH group of donors

Biological Process: response to manganese ion; response to magnesium ion; cellular protein metabolic process; response to zinc ion; response to cobalt ion; response to calcium ion
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with D2hgdh recombinant proteinDiseases associated with D2hgdh recombinant protein
 Products by Pathway  Pathway Diagram
 Interconversion Of 2-oxoglutarate And 2-hydroxyglutarate Pathway antibodies  Interconversion Of 2-oxoglutarate And 2-hydroxyglutarate Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway antibodies  Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway Diagram
 The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram
 Disease Name  Pubmed Publications
 2-Hydroxyglutaricaciduria Antibodies  >3 publications with D2hgdh and 2-Hydroxyglutaricaciduria
 Aneuploidy Antibodies  >2 publications with D2hgdh and Aneuploidy
 Amino Acid Metabolism, Inborn Errors Antibodies  >2 publications with D2hgdh and Amino Acid Metabolism, Inborn Errors
 Bone Diseases Antibodies  >1 publications with D2hgdh and Bone Diseases
 Child Behavior Disorders Antibodies  >1 publications with D2hgdh and Child Behavior Disorders
Organs/Tissues associated with D2hgdh recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with D2hgdh and Brain
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