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PHGDH recombinant protein :: D-3-phosphoglycerate dehydrogenase (PHGDH) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1174268 PHGDH recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $955 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,150 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,280 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,385 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,400 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,415 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,570 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,010 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,095 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,115 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,390 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,750 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

D-3-phosphoglycerate dehydrogenase (PHGDH), Recombinant Protein

 Also Known As   

Recombinant Human D-3-phosphoglycerate dehydrogenase (PHGDH)

 Product Gene Name   

PHGDH recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-533aa, Full Length of Mature Protein
 Sequence    AFANLRKVLI SDSLDPCCRK ILQDGGLQVV EKQNLSKEEL IAELQDCEGL IVRSATKVTA DVINAAEKLQ VVGRAGTGVD NVDLEAATRK GILVMNTPNG NSLSAAELTC GMIMCLARQI PQATASMKDG KWERKKFMGT ELNGKTLGIL GLGRIGREVA TRMQSFGMKT IGYDPIISPE VSASFGVQQL PLEEIWPLCD FITVHTPLLP STTGLLNDNT FAQCKKGVRV VNCARGGIVD EGALLRALQS GQCAGAALDV FTEEPPRDRA LVDHENVISC PHLGASTKEA QSRCGEEIAV QFVDMVKGKS LTGVVNAQAL TSAFSPHTKP WIGLAEALGT LMRAWAGSPK GTIQVITQGT SLKNAGNCLS PAVIVGLLKE ASKQADVNLV NAKLLVKEAG LNVTTSHSPA APGEQGFGEC LLAVALAGAP YQAVGLVQGT TPVLQGLNGA VFRPEVPLRR DLPLLLFRTQ TSDPAMLPTM IGLLAEAGVR LLSYQTSLVS DGETWHVMGI SSLLPSLEAW KQHVTEAFQF HF
 OMIM    256520
 3D Structure    ModBase 3D Structure for O43175
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PHGDH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PHGDH. It may not necessarily be applicable to this product.
 NCBI GI #    23308577
 NCBI GeneID    26227
 NCBI Accession #    NP_006614.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006623.3 [Other Products]
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 UniProt Primary Accession #    O43175 [Other Products]
 UniProt Secondary Accession #    Q5SZU3; Q9BQ01; B2RD08 [Other Products]
 UniProt Related Accession #    O43175 [Other Products]
 Molecular Weight    56,651 Da
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 NCBI Official Full Name    D-3-phosphoglycerate dehydrogenase
 NCBI Official Synonym Full Names    phosphoglycerate dehydrogenase
 NCBI Official Symbol    PHGDH [Similar Products]
 NCBI Official Synonym Symbols   
NLS; PDG; PGD; NLS1; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; PHGDHD; HEL-S-113
[Similar Products]
 NCBI Protein Information    D-3-phosphoglycerate dehydrogenase
 UniProt Protein Name    D-3-phosphoglycerate dehydrogenase
 UniProt Synonym Protein Names   
2-oxoglutarate reductase
 UniProt Gene Name    PHGDH [Similar Products]
 UniProt Synonym Gene Names    PGDH3; 3-PGDH [Similar Products]
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 NCBI Summary for PHGDH    This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
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 UniProt Comments for PHGDH    Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
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 Research Articles on PHGDH    1. Data indicate that the expression of PHGDH is increased in pancreatic cancer and is an independent molecular prognostic factor for pancreatic cancer patients. In addition, PHGDH controls cell proliferation, migration and invasion abilities.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PHGDH recombinant proteinPathways associated with PHGDH recombinant protein
 Reference Product  PubMed Publications
 PSPH recombinant protein  >9 publications with PHGDH and PSPH
 PSAT1 recombinant protein  >9 publications with PHGDH and PSAT1
 ASNS recombinant protein  >1 publications with PHGDH and ASNS
 SHMT2 recombinant protein  >1 publications with PHGDH and SHMT2
 Products by Pathway  Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
Diseases associated with PHGDH recombinant proteinOrgans/Tissues associated with PHGDH recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >12 publications with PHGDH and Breast Neoplasms
 Melanoma Antibodies  >7 publications with PHGDH and Melanoma
 Nervous System Diseases Antibodies  >7 publications with PHGDH and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >6 publications with PHGDH and Cell Transformation, Neoplastic
 Brain Diseases Antibodies  >5 publications with PHGDH and Brain Diseases
 Disease Models, Animal Antibodies  >4 publications with PHGDH and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with PHGDH and Liver Diseases
 Phosphoglycerate Dehydrogenase Deficiency Antibodies  >3 publications with PHGDH and Phosphoglycerate Dehydrogenase Deficiency
 Neoplasms, Experimental Antibodies  >3 publications with PHGDH and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with PHGDH and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with PHGDH and Brain
 Liver Antibodies  >8 publications with PHGDH and Liver
 Blood Antibodies  >5 publications with PHGDH and Blood
 Lung Antibodies  >4 publications with PHGDH and Lung
 Uterus Antibodies  >2 publications with PHGDH and Uterus
 Nerve Antibodies  >2 publications with PHGDH and Nerve
 Bone Antibodies  >2 publications with PHGDH and Bone
 Embryonic Tissue Antibodies  >2 publications with PHGDH and Embryonic Tissue
 Mammary Gland Antibodies  >1 publications with PHGDH and Mammary Gland
 Muscle Antibodies  >1 publications with PHGDH and Muscle
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