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PHGDH recombinant protein :: D-3-phosphoglycerate dehydrogenase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717072
SDS-PAGE
Unit / Price
0.05 mg  /  $195 +1 FREE 8GB USB
0.2 mg  /  $465 +1 FREE 8GB USB
0.5 mg  /  $815 +1 FREE 8GB USB
1 mg  /  $1,290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

D-3-phosphoglycerate dehydrogenase (PHGDH), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant human D-3-phosphoglycerate dehydrogenase

 Product Gene Name   

PHGDH recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    AFANLRKVLI SDSLDPCCRK ILQDGGLQVV EKQNLSKEEL IAELQDCEGL IVRSATKVTA DVINAAEKLQ VVGRAGTGVD NVDLEAATRK GILVMNTPNG NSLSAAELTC GMIMCLARQI PQATASMKDG KWERKKFMGT ELNGKTLGIL GLGRIGREVA TRMQSFGMKT IGYDPIISPE VSASFGVQQL PLEEIWPLCD FITVHTPLLP STTGLLNDNT FAQCKKGVRV VNCARGGIVD EGALLRALQS GQCAGAALDV FTEEPPRDRA LVDHENVISC PHLGASTKEA QSRCGEEIAV QFVDMVKGKS LTGVVNAQAL TSAFSPHTKP WIGLAEALGT LMRAWAGSPK GTIQVITQGT SLKNAGNCLS PAVIVGLLKE ASKQADVNLV NAKLLVKEAG LNVTTSHSPA APGEQGFGEC LLAVALAGAP YQAVGLVQGT TPVLQGLNGA VFRPEVPLRR DLPLLLFRTQ TSDPAMLPTM IGLLAEAGVR LLSYQTSLVS DGETWHVMGI SSLLPSLEAW KQHVTEAFQF HF
 Chromosome Location    Chromosome: 1; NC_000001.10 (120254419..120286849). Location: 1p12
 OMIM    601815
 3D Structure    ModBase 3D Structure for O43175
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 Host    E Coli
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 Purity/Purification    >=90%(SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PHGDH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PHGDH recombinant protein

   3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH.
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 SDS-PAGE of PHGDH recombinant protein    PHGDH recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PHGDH. It may not necessarily be applicable to this product.
 NCBI GI #    217272837
 NCBI GeneID    26227
 NCBI Accession #    NP_006614.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006623 [Other Products]
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 UniProt Primary Accession #    O43175 [Other Products]
 UniProt Secondary Accession #    Q5SZU3; Q9BQ01; B2RD08 [Other Products]
 UniProt Related Accession #    O43175; Q5SZU1; Q8N5M8; Q96RV5; Q96RV6; Q96RV7; Q96RV8; Q96RV9; Q9UMY2; Q9UMY3 [Other Products]
 Molecular Weight    63kD [Similar Products]
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 NCBI Official Full Name    Homo sapiens phosphoglycerate dehydrogenase (PHGDH), mRNA
 NCBI Official Synonym Full Names    phosphoglycerate dehydrogenase
 NCBI Official Symbol    PHGDH [Similar Products]
 NCBI Official Synonym Symbols   
PDG; PGD; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; MGC3017
[Similar Products]
 NCBI Protein Information    D-3-phosphoglycerate dehydrogenase; OTTHUMP00000013926; OTTHUMP00000013927
 UniProt Protein Name    D-3-phosphoglycerate dehydrogenase
 Protein Family    D-3-phosphoglycerate dehydrogenase
 UniProt Gene Name    PHGDH [Similar Products]
 UniProt Synonym Gene Names    PGDH3 [Similar Products]
 UniProt Entry Name    SERA_HUMAN
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 NCBI Summary for PHGDH    3-Phosphoglycerate dehydrogenase (PHGDH; EC 1.1.1.95) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.[supplied by OMIM, Apr 2004]
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 UniProt Comments for PHGDH    Catalytic activity: 3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH. Ref.102-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH. Ref.10Pathway: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.Subunit structure: Homotetramer By similarity.Induction: Induced by 17-beta-estradiol (estrogenic ligand) and 4-hydroxytamoxifen (agonist/antagonist ligand). Positively regulated by the transcription factors SP1 and NF-Y. Ref.11 Ref.12Involvement in disease: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.Sequence similarities: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.Biophysicochemical propertiesKinetic parameters:KM=21.6 µM for 3-phosphohydroxypyruvate Ref.16Vmax=35 nmol/min/mg enzyme with 3-phosphohydroxypyruvate as substrate (in patient-derived fibroblasts)Vmax=168 nmol/min/mg enzyme with 3-phosphohydroxypyruvate as substrate (in 3-PGDH overexpressed cells)
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 Research Articles on PHGDH    1. The frequency of antibodies to Phgdh is much higher in patients with autoimmune hepatitis than in patients with other types of hepatitis or normal controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PHGDH recombinant proteinDiseases associated with PHGDH recombinant protein
 Products by Pathway  Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Disease Name  Pubmed Publications
 PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY Antibodies  >9 publications with PHGDH and PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY
 Neoplasms Antibodies  >6 publications with PHGDH and Neoplasms
 Liver Diseases Antibodies  >3 publications with PHGDH and Liver Diseases
 Breast Neoplasms Antibodies  >3 publications with PHGDH and Breast Neoplasms
 Liver Cirrhosis Antibodies  >2 publications with PHGDH and Liver Cirrhosis
 Hepatitis C, Chronic Antibodies  >2 publications with PHGDH and Hepatitis C, Chronic
 Cell Transformation, Neoplastic Antibodies  >1 publications with PHGDH and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >1 publications with PHGDH and Carcinoma
 Neoplasm Metastasis Antibodies  >1 publications with PHGDH and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >1 publications with PHGDH and Adenocarcinoma
Organs/Tissues associated with PHGDH recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with PHGDH and Brain
 Liver Antibodies  >6 publications with PHGDH and Liver
 Blood Antibodies  >3 publications with PHGDH and Blood
 Nerve Antibodies  >2 publications with PHGDH and Nerve
 Embryonic Tissue Antibodies  >2 publications with PHGDH and Embryonic Tissue
 Bone Antibodies  >1 publications with PHGDH and Bone
 Muscle Antibodies  >1 publications with PHGDH and Muscle
 Uterus Antibodies  >1 publications with PHGDH and Uterus
 Kidney Antibodies  >1 publications with PHGDH and Kidney
 Lung Antibodies  >1 publications with PHGDH and Lung
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