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DECR1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203975
SDS-PAGE
Unit / Price
0.05 mg  /  $375 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DECR1, Recombinant Protein

 Also Known As   

DECR1, 35-335aa, Human, His tag, E Coli

 Product Synonym Names    2; 4-dienoyl-CoA reductase; mitochondrial; DECR; NADPH; SDR18C1
 Product Gene Name   

DECR1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MNTEALQSKF FSPLQKAMLP PNSFQGKVAF ITGGGTGLGK GMTTLLSSLG AQCVIASRKM DVLKATAEQI SSQTGNKVHA IQCDVRDPDM VQNTVSELIK VAGHPNIVIN NAAGNFISPT ERLSPNAWKT ITDIVLNGTA FVTLEIGKQL IKAQKGAAFL SITTIYAETG SGFVVPSASA KAGVEAMSKS LAAEWGKYGM RFNVIQPGPI KTKGAFSRLD PTGTFEKEMI GRIPCGRLGT VEELANLAAF LCSDYASWIN GAVIKFDGGE EVLISGEFND LRKVTKEQWD TIEELIRKTK GS
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT.
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of DECR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for DECR1 recombinant protein

   DECR1 is a mitochondrial protein that exists as a homotetramer and belongs to the family of short-chain dehydrogenases/reductases. It functions as an auxiliary enzyme of beta-oxidation andt participates in the metabolism of unsaturated fatty enoyl-CoA esters. Specifically, DECR1 uses NADP+ to catalyze the reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA, which can then be used as an intermediate in the Krebs cycle. Additionally, DECR1 is thought to function as a tumor suppressor, possibly downregulating the expression of Neu and slowing the rate of tumorigenesis. Recombinant human DECR1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for DECR1 recombinant protein    Cancer
 Applications Tested/Suitable for DECR1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of DECR1 recombinant protein    DECR1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for DECR1. It may not necessarily be applicable to this product.
 NCBI GI #    4503301
 NCBI GeneID    1666
 NCBI Accession #    NP_001350 [Other Products]
 NCBI GenBank Nucleotide #    NM_001359.1 [Other Products]
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 UniProt Secondary Accession #    Q2M304; Q93085; B7Z6B8 [Other Products]
 UniProt Related Accession #    Q16698 [Other Products]
 Molecular Weight    34.4 kDa (322aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    2,4-dienoyl-CoA reductase, mitochondrial
 NCBI Official Synonym Full Names    2,4-dienoyl CoA reductase 1, mitochondrial
 NCBI Official Symbol    DECR1 [Similar Products]
 NCBI Official Synonym Symbols   
DECR; NADPH; SDR18C1
[Similar Products]
 NCBI Protein Information    2,4-dienoyl-CoA reductase, mitochondrial; 4-enoyl-CoA reductase; short chain dehydrogenase/reductase family 18C, member 1
 UniProt Protein Name    2,4-dienoyl-CoA reductase, mitochondrial
 UniProt Synonym Protein Names   
2,4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH]; Short chain dehydrogenase/reductase family 18C member 1
 Protein Family    2,4-dienoyl-CoA reductase
 UniProt Gene Name    DECR1 [Similar Products]
 UniProt Synonym Gene Names    DECR; SDR18C1; 4-enoyl-CoA reductase [NADPH] [Similar Products]
 UniProt Entry Name    DECR_HUMAN
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 NCBI Summary for DECR1    This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DECR1    DECR1: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.

Protein type: EC 1.3.1.34; Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 8q21.3

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm; nucleus

Molecular Function: oxidoreductase activity, acting on NADH or NADPH; 2,4-dienoyl-CoA reductase (NADPH) activity

Biological Process: fatty acid beta-oxidation; cellular lipid metabolic process; protein homotetramerization
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Product References and Citations for DECR1 recombinant protein

   Koivuranta KT., et al. (1994) Biochem J. 304(3):787-92.
Roe CR., et al. (1990) J Clin Invest. 85(5):1703-7.
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 Research Articles on DECR1    1. Our study is the first to demonstrate the novel function of UA in NET formation and may provide insight into the management of patients with hyperuricemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DECR1 recombinant proteinDiseases associated with DECR1 recombinant protein
 Products by Pathway  Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Mitochondrial Fatty Acid Beta-Oxidation Pathway antibodies  Mitochondrial Fatty Acid Beta-Oxidation Pathway Diagram
 Mitochondrial Fatty Acid Beta-oxidation Of Unsaturated Fatty Acids Pathway antibodies  Mitochondrial Fatty Acid Beta-oxidation Of Unsaturated Fatty Acids Pathway Diagram
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >1 publications with DECR1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >1 publications with DECR1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with DECR1 and Disease Models, Animal
 Fatty Liver Antibodies  >1 publications with DECR1 and Fatty Liver
 Necrosis Antibodies  >1 publications with DECR1 and Necrosis
Organs/Tissues associated with DECR1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with DECR1 and Muscle
 Connective Tissue Antibodies  >2 publications with DECR1 and Connective Tissue
 Blood Antibodies  >1 publications with DECR1 and Blood
 Ovary Antibodies  >1 publications with DECR1 and Ovary
 Mammary Gland Antibodies  >1 publications with DECR1 and Mammary Gland
 Heart Antibodies  >1 publications with DECR1 and Heart
 Liver Antibodies  >1 publications with DECR1 and Liver
 Uterus Antibodies  >1 publications with DECR1 and Uterus
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