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DEFA1B recombinant protein :: DEFENSIN ALPHA 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS232451 DEFA1B recombinant protein
Unit / Price
0.02 mg  /  $450 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DEFENSIN ALPHA 1 (DEFA1B), Recombinant Protein

 Also Known As   

RECOMBINANT HUMAN DEFENSIN ALPHA 1

 Product Gene Name   

DEFA1B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125220
 3D Structure    ModBase 3D Structure for P59665
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 Purity/Purification    >98% by SDS PAGE and HPLC analysis
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Approximate Protein Concentration: 0.1mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.2ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Activity    Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/ml.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of DEFA1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DEFA1B recombinant protein

   Recombinant Human Defensin-alpha-1 is a 3.4kDa peptide comprised of 30 amino acid residues corresponding to full-length mature human defenstin alpha 1. Defensin-alpha-1, otherwise known as HNP-1, is a secreted cationic antimicrobial peptide and member of the alpha-defensin family, which plays an important role in the innate immune response against microbial infections.
 Applications Tested/Suitable for DEFA1B recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for DEFA1B recombinant protein    ELISA: Recombinant human defensin-alpha-1 may be used as a standard for ELISA applications with either a purified anti human defensin-alpha-1 antibody or a biotinylated anti human defensin-alpha-1 antibody.
Western Blot: Recombinant human defensin-alpha-1 may be used as a positive control for Western Blotting applications with either a purifed human defensin-alpha-1 antibody or a biotinylated human defensin-alpha-1 antibody.
ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane
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NCBI/Uniprot data below describe general gene information for DEFA1B. It may not necessarily be applicable to this product.
 NCBI GI #    124248516
 NCBI GeneID    728358
 NCBI Accession #    NP_001035965.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042500.1 [Other Products]
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 UniProt Primary Accession #    P59665 [Other Products]
 UniProt Secondary Accession #    P11479; Q14125; Q6EZF6 [Other Products]
 UniProt Related Accession #    P59665 [Other Products]
 Molecular Weight    3.4kD (30 amino acid residues) [Similar Products]
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 NCBI Official Full Name    neutrophil defensin 1 isoform 2 preproprotein
 NCBI Official Synonym Full Names    defensin, alpha 1B
 NCBI Official Symbol    DEFA1B [Similar Products]
 NCBI Official Synonym Symbols   
HP1; HP-1; HNP-1
[Similar Products]
 NCBI Protein Information    neutrophil defensin 1
 UniProt Protein Name    Neutrophil defensin 1
 UniProt Synonym Protein Names   
Defensin, alpha 1; HNP-1; HP-1; HP1
 UniProt Gene Name    DEFA1 [Similar Products]
 UniProt Synonym Gene Names    DEF1; DEFA2; MRS; HP-1; HP1; HP-2; HP2 [Similar Products]
 UniProt Entry Name    DEF1_HUMAN
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 NCBI Summary for DEFA1B    Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
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 UniProt Comments for DEFA1B    defensin, alpha 1: Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. Belongs to the alpha-defensin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular matrix; extracellular space; Golgi lumen; extracellular region

Biological Process: defense response to Gram-positive bacterium; estrogen receptor signaling pathway; innate immune response in mucosa; killing of cells of another organism; antibacterial humoral response; innate immune response; immune response; chemotaxis; defense response to virus; defense response to fungus
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 Research Articles on DEFA1B    1. DEFA1B encodes an antibacterial peptide that is bacteriocidal against S. aureus, E. coli, and P. aeruginosa.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DEFA1B recombinant protein
 Products by Pathway  Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
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