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DEFB4B recombinant protein :: DEFENSIN BETA 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS232312 DEFB4B recombinant protein
Unit / Price
0.02 mg  /  $430 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DEFENSIN BETA 2 (DEFB4B), Recombinant Protein

 Also Known As   


 Product Gene Name   

DEFB4B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602215
 3D Structure    ModBase 3D Structure for O15263
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 Purity/Purification    >98% by SDS PAGE and HPLC analysis.
 Form/Format    Purified recombinant protein - lyophilised
 Concentration    Approximate Protein Concentration: 0.1mg/ml after reconstitution (lot specific)
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 Reconstitution    Reconstitute with 0.2ml 10mM acetic acid. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For extended storage the addition of 0.1% bovine serum albumin (BSA) is recommended.
 Activity    Determined by its ability to chemoattract immature dendritic cells using a concentration of 10.0-100.0 ng/ml.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 3 months from date of reconstitution.
 Other Notes    Small volumes of DEFB4B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for DEFB4B recombinant protein

   Recombinant human defensin beta-2 (BD-2), is a 4.3 kDa peptide comprised of 41 amino acid residues. BD-2, a member of the beta defensin family, is secreted at epithelial surfaces of the skin and respiratory tract and by some leukocytes. This defensin is induced by bacterial products and cytokines during inflammation and functions as part of the innate immune system, having a wide ranging antimicrobial activity. BD-2 also functions as a chemoattractant to immature dendritic cells and memory T cells and acts as a ligand for TLR4, upregulating co-stimulatory molecules and inducing dendritic cell maturation.
 Applications Tested/Suitable for DEFB4B recombinant protein   

ELISA (EIA), Functional Assays (FN), Western Blot (WB)

 Application Notes for DEFB4B recombinant protein    ELISA: Recombinant human BD-2 may be used as a standard in ELISA applications with either a purified human BD-2 antibody or a biotinylated human BD-2 antibody.
Western Blot: Recombinant human BD-2 may be used as the positive control in Western Blotting applications with either a purified human BD-2 antibody or a biotinylated human BD-2 antibody.
ELISA: Minimum Dilution: 0.2; Maximum Dilution: 0.4ng/well
Functional Assays: Minimum Dilution: 10; Maximum Dilution: 100ng/ml
Western Blotting: Minimum Dilution: 1.5; Maximum Dilution: 3.0ng/lane
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NCBI/Uniprot data below describe general gene information for DEFB4B. It may not necessarily be applicable to this product.
 NCBI GI #    327532771
 NCBI GeneID    100289462
 NCBI Accession #    NP_001192195.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001205266.1 [Other Products]
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 UniProt Primary Accession #    O15263 [Other Products]
 UniProt Secondary Accession #    Q52LC0 [Other Products]
 Molecular Weight    4.3kD (41 amino acid sequence/residues) [Similar Products]
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 NCBI Official Full Name    beta-defensin 4B
 NCBI Official Synonym Full Names    defensin, beta 4B
 NCBI Official Symbol    DEFB4B [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    beta-defensin 4B; beta defensin 2; beta defensin-2; beta-defensin 2; defensin, beta 4, pseudogene
 UniProt Protein Name    Beta-defensin 4A
 UniProt Synonym Protein Names   
Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1; SAP1
 UniProt Gene Name    DEFB4A [Similar Products]
 UniProt Synonym Gene Names    DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1 [Similar Products]
 UniProt Entry Name    DFB4A_HUMAN
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 NCBI Summary for DEFB4B    Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]
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 UniProt Comments for DEFB4B    defensin, beta 2: Has antibacterial activity (Potential). Belongs to the beta-defensin family. LAP/TAP subfamily.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: Golgi lumen; extracellular region

Biological Process: G-protein coupled receptor protein signaling pathway; defense response to bacterium; innate immune response; immune response; chemotaxis
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 Research Articles on DEFB4B    1. The encoded peptide has antimicrobial activity against E.coli, S. aureus, and P. aeruginosa.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with DEFB4B recombinant protein
 Products by Pathway  Pathway Diagram
 Beta Defensins Pathway antibodies  Beta Defensins Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
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