AF329477
[Other Products]
Molecular Weight
92.1kDa (850aa), confirmed by MALDI-TOF.
NCBI Official Full Name
Arthrobacter globiformis strain NRRL B-2979 N,N-dimethylglycine oxidase operon, complete sequence; and hypothetical protein, putative formate dehydrogenase (fdh), putative molibdopterin biosynthesis protein (moeA), putative IclR-family transcriptional reg
UniProt Protein Name
Dimethylglycine oxidase
UniProt Synonym Gene Names
UniProt Comments for DMGO
Catalyzes the oxidative demethylation of N,N-dimethylglycine to yield sarcosine, formaldehyde and hydrogen peroxide. The oxidation of dimethylglycine is coupled to the synthesis of 5,10-methylenetetrahydrofolate through an unusual substrate channeling mechanism. This channeling occurs by nonbiased diffusion of the iminium intermediate through a large solvent cavity connecting active site 1 (N-terminus) and active site 2 (C-terminus). The synthesis of 5,10-methylenetetrahydrofolate (at active site 2) prevents the accumulation of formaldehyde, formed by hydrolysis of the iminium intermediate product (at active site 1). Does not oxidize sarcosine.
Product References and Citations for DMGO recombinant protein
Rolandas Meskys., et al: Eur. J. Biochem (2001) 268:3390-3398 ; Basran J., et al, Biochemistry. (2006) 45:11151-61
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