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PRKDC recombinant protein :: DNA-dependent protein kinase catalytic subunit (PRKDC), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958970 PRKDC recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,055 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,055 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,285 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,285 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,595 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,595 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,055 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,055 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,055 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $3,145 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA-dependent protein kinase catalytic subunit (PRKDC), partial, Recombinant Protein

 Also Known As   

Recombinant Human DNA-dependent protein kinase catalytic subunit (PRKDC), partial

 Product Synonym Names    DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; EC=2.7.11.1; DNPK1; p460
 Product Gene Name   

PRKDC recombinant protein

[Similar Products]
 Product Synonym Gene Name    PRKDC; HYRC; HYRC1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    3747-4015; PI3K/PI4K domain
 Sequence    EHPFLVKGGE DLRQDQRVEQ LFQVMNGILA QDSACSQRAL QLRTYSVVPM TSRLGLIEWL ENTVTLKDLL LNTMSQEEKA AYLSDPRAPP CEYKDWLTKM SGKHDVGAYM LMYKGANRTE TVTSFRKRES KVPADLLKRA FVRMSTSPEA FLALRSHFAS SHALICISHW ILGIGDRHLN NFMVAMETGG VIGIDFGHAF GSATQFLPVP ELMPFRLTRQ FINLMLPMKE TGLMYSIMVH ALRAFRSDPG LLTNTMDVFV KEPSFDWKN
 OMIM    600899
 3D Structure    ModBase 3D Structure for P78527
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PRKDC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PRKDC. It may not necessarily be applicable to this product.
 NCBI GI #    126032350
 NCBI GeneID    5591
 NCBI Accession #    NP_001075109.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001081640.1 [Other Products]
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 UniProt Primary Accession #    P78527 [Other Products]
 UniProt Secondary Accession #    P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3 [Other Products]
 UniProt Related Accession #    P78527 [Other Products]
 Molecular Weight    465,501 Da
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 NCBI Official Full Name    DNA-dependent protein kinase catalytic subunit isoform 2
 NCBI Official Synonym Full Names    protein kinase, DNA-activated, catalytic polypeptide
 NCBI Official Symbol    PRKDC [Similar Products]
 NCBI Official Synonym Symbols   
HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7; DNA-PKcs
[Similar Products]
 NCBI Protein Information    DNA-dependent protein kinase catalytic subunit; p460; DNA-PK catalytic subunit; hyper-radiosensitivity of murine scid mutation, complementing 1
 UniProt Protein Name    DNA-dependent protein kinase catalytic subunit
 UniProt Synonym Protein Names   
DNPK1; p460
 UniProt Gene Name    PRKDC [Similar Products]
 UniProt Synonym Gene Names    HYRC; HYRC1; DNA-PK catalytic subunit; DNA-PKcs [Similar Products]
 UniProt Entry Name    PRKDC_HUMAN
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 NCBI Summary for PRKDC    This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
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 UniProt Comments for PRKDC    DNAPK: an atypical protein kinase of the PIKK family. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. and modulation of transcription. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Defects cause severe combined immune deficiency (SCID) which is characterized by a lack of mature functional lymphocytes and a high susceptibility to lethal opportunistic infections. Required for repair of radiation-induced dsDNA breaks. Loss of function in mice or horses leads to the SCID (severe combined immune deficiency) phenotype due to failure of immunoglobulin rearrangement. Target of mutation in mismatch repair-deficient colorectal cancer. Inhibitor: KU-7059. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; Kinase, protein; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); Nucleolus; EC 2.7.11.1; ATYPICAL group; PIKK family; DNAPK subfamily

Chromosomal Location of Human Ortholog: 8q11

Cellular Component: nucleoplasm; transcription factor complex; membrane; nucleolus; DNA-dependent protein kinase complex; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; enzyme binding; DNA binding; DNA-dependent protein kinase activity; transcription factor binding; ATP binding; protein kinase activity

Biological Process: positive regulation of apoptosis; heart development; germ cell programmed cell death; T cell differentiation in the thymus; rhythmic process; double-strand break repair via nonhomologous end joining; negative regulation of protein amino acid phosphorylation; double-strand break repair; positive regulation of interferon type I production; response to gamma radiation; telomere maintenance; pro-B cell differentiation; somitogenesis; protein destabilization; immunoglobulin V(D)J recombination; B cell lineage commitment; protein modification process; regulation of circadian rhythm; DNA repair; double-strand break repair via homologous recombination; T cell lineage commitment; peptidyl-serine phosphorylation; DNA damage response, signal transduction resulting in induction of apoptosis; cellular response to insulin stimulus; innate immune response; T cell receptor V(D)J recombination; positive regulation of transcription from RNA polymerase II promoter; brain development

Disease: Immunodeficiency 26 With Or Without Neurologic Abnormalities
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 Research Articles on PRKDC    1. Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone-induced hematotoxicity in which it coordinates DNA DSB repair, cell cycle progression, and apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRKDC recombinant proteinPathways associated with PRKDC recombinant protein
 Reference Product  PubMed Publications
 ATM recombinant protein  >248 publications with PRKDC and ATM
 XRCC5 recombinant protein  >210 publications with PRKDC and XRCC5
 JUN recombinant protein  >126 publications with PRKDC and JUN
 XRCC4 recombinant protein  >98 publications with PRKDC and XRCC4
 DCLRE1C recombinant protein  >37 publications with PRKDC and DCLRE1C
 CASP3 recombinant protein  >36 publications with PRKDC and CASP3
 PARP1 recombinant protein  >27 publications with PRKDC and PARP1
 RPA1 recombinant protein  >22 publications with PRKDC and RPA1
 NBN recombinant protein  >15 publications with PRKDC and NBN
 TP53 recombinant protein  >14 publications with PRKDC and TP53
 Products by Pathway  Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
Diseases associated with PRKDC recombinant proteinOrgans/Tissues associated with PRKDC recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >358 publications with PRKDC and Neoplasms
 Chromosome Aberrations Antibodies  >76 publications with PRKDC and Chromosome Aberrations
 Nervous System Diseases Antibodies  >68 publications with PRKDC and Nervous System Diseases
 Breast Neoplasms Antibodies  >44 publications with PRKDC and Breast Neoplasms
 Drug Toxicity Antibodies  >40 publications with PRKDC and Drug Toxicity
 Lymphoma Antibodies  >37 publications with PRKDC and Lymphoma
 Neoplasms, Experimental Antibodies  >31 publications with PRKDC and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >30 publications with PRKDC and Lung Neoplasms
 Lung Diseases Antibodies  >30 publications with PRKDC and Lung Diseases
 Head and Neck Neoplasms Antibodies  >22 publications with PRKDC and Head and Neck Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >163 publications with PRKDC and Blood
 Lung Antibodies  >51 publications with PRKDC and Lung
 Brain Antibodies  >50 publications with PRKDC and Brain
 Bone Antibodies  >37 publications with PRKDC and Bone
 Bone Marrow Antibodies  >33 publications with PRKDC and Bone Marrow
 Liver Antibodies  >32 publications with PRKDC and Liver
 Spleen Antibodies  >26 publications with PRKDC and Spleen
 Ovary Antibodies  >22 publications with PRKDC and Ovary
 Thymus Antibodies  >22 publications with PRKDC and Thymus
 Kidney Antibodies  >21 publications with PRKDC and Kidney
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