NP_002687.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,294 Da
NCBI Official Full Name
DNA-directed RNA polymerase II subunit RPB7
NCBI Official Synonym Full Names
RNA polymerase II subunit G
NCBI Protein Information
DNA-directed RNA polymerase II subunit RPB7
UniProt Protein Name
DNA-directed RNA polymerase II subunit RPB7
UniProt Synonym Protein Names
DNA-directed RNA polymerase II subunit G; RNA polymerase II 19 kDa subunit; RPB19
UniProt Synonym Gene Names
NCBI Summary for POLR2G
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]
UniProt Comments for POLR2G
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (). Binds RNA.
Research Articles on POLR2G
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Products associated with POLR2G recombinant protein
Pathways associated with POLR2G recombinant protein
Diseases associated with POLR2G recombinant protein
Organs/Tissues associated with POLR2G recombinant protein
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