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POLB recombinant protein :: DNA polymerase beta (POLB) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950488 POLB recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $745 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $995 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,000 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,095 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,160 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,245 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,265 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,315 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,555 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,820 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,885 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,995 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,425 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA polymerase beta (POLB), Recombinant Protein

 Also Known As   

Recombinant Human DNA polymerase beta (POLB)

 Product Gene Name   

POLB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-335aa, Full length protein
 Sequence    MSKRKAPQET LNGGITDMLT ELANFEKNVS QAIHKYNAYR KAASVIAKYP HKIKSGAEAK KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL TRVSGIGPSA ARKFVDEGIK TLEDLRKNED KLNHHQRIGL KYFGDFEKRI PREEMLQMQD IVLNEVKKVD SEYIATVCGS FRRGAESSGD MDVLLTHPSF TSESTKQPKL LHQVVEQLQK VHFITDTLSK GETKFMGVCQ LPSKNDEKEY PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP LGVTGVAGEP LPVDSEKDIF DYIQWKYREP KDRSE
 OMIM    174760
 3D Structure    ModBase 3D Structure for P06746
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of POLB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for POLB. It may not necessarily be applicable to this product.
 NCBI GI #    4505931
 NCBI GeneID    5423
 NCBI Accession #    NP_002681.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002690.2 [Other Products]
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 UniProt Primary Accession #    P06746 [Other Products]
 UniProt Secondary Accession #    Q3KP48; Q6FI34; B2RC78 [Other Products]
 UniProt Related Accession #    P06746 [Other Products]
 Molecular Weight    38,178 Da
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 NCBI Official Full Name    DNA polymerase beta
 NCBI Official Synonym Full Names    DNA polymerase beta
 NCBI Official Symbol    POLB [Similar Products]
 NCBI Protein Information    DNA polymerase beta
 UniProt Protein Name    DNA polymerase beta
 Protein Family    DNA polymerase
 UniProt Gene Name    POLB [Similar Products]
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 NCBI Summary for POLB    The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
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 UniProt Comments for POLB    Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
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 Research Articles on POLB    1. POLB, is located in the mitochondria and plays a significant role in mitochondrial BER, mtDNA integrity and mitochondrial function. [REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with POLB recombinant proteinPathways associated with POLB recombinant protein
 Reference Product  PubMed Publications
 XRCC1 recombinant protein  >12 publications with POLB and XRCC1
 PCNA recombinant protein  >10 publications with POLB and PCNA
 APEX1 recombinant protein  >9 publications with POLB and APEX1
 NEIL1 recombinant protein  >3 publications with POLB and NEIL1
 Products by Pathway  Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway antibodies  Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
Diseases associated with POLB recombinant proteinOrgans/Tissues associated with POLB recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >29 publications with POLB and Neoplasms
 Carcinoma Antibodies  >9 publications with POLB and Carcinoma
 Drug Toxicity Antibodies  >5 publications with POLB and Drug Toxicity
 Lung Neoplasms Antibodies  >4 publications with POLB and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with POLB and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >3 publications with POLB and Breast Neoplasms
 Urinary Bladder Neoplasms Antibodies  >3 publications with POLB and Urinary Bladder Neoplasms
 Pancreatic Neoplasms Antibodies  >2 publications with POLB and Pancreatic Neoplasms
 Anemia Antibodies  >2 publications with POLB and Anemia
 Hyperplasia Antibodies  >2 publications with POLB and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with POLB and Lung
 Liver Antibodies  >3 publications with POLB and Liver
 Blood Antibodies  >3 publications with POLB and Blood
 Kidney Antibodies  >2 publications with POLB and Kidney
 Brain Antibodies  >2 publications with POLB and Brain
 Prostate Antibodies  >1 publications with POLB and Prostate
 Eye Antibodies  >1 publications with POLB and Eye
 Embryonic Tissue Antibodies  >1 publications with POLB and Embryonic Tissue
 Stomach Antibodies  >1 publications with POLB and Stomach
 Testis Antibodies  >1 publications with POLB and Testis
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