Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource rightarrow Recombinant Protein rightarrow PAPD7  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
Our Best Sellers moreseparator
 • thiopurine S-methyltransferase (TPMT) ELISA Kit
 • CD80 Antibody
 • Urinary Isoprostane Assay Kit
 • Keratin, type II cytoskeletal 5 (Krt5) Recombinant Protein
 • Glutathione Reductase (GR) ELISA Kit
 • CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Antibody
 • Hck Antibody
 • KLK6 cDNA Clone
 • Stromal Cell Derived Factor 1 (SDF1) ELISA Kit
 • Receptor activator of nuclear factor kappa B ligand, RANKL ELISA Kit
 • Mucin-5 Subtype Ac (MUC5AC) ELISA Kit
 • Pentosidine ELISA Kit
 • STAT1 (pY701) (STAT1 (pY701)) Antibody
 • HBcAg Antibody
 downarrow more ...
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PAPD7 recombinant protein :: DNA polymerase sigma (PAPD7) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1428582
Unit / Price
You will be redirected to our replacement product
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA polymerase sigma (PAPD7), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human DNA polymerase sigma (PAPD7)

 Product Synonym Names    DNA polymerase sigma; EC=; DNA polymerase kappa; LAK-1; PAP-associated domain-containing protein 7; Terminal uridylyltransferase 5; TUTase 5; Topoisomerase-related function protein 4-1; TRF4-1
 Product Gene Name   

PAPD7 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PAPD7; POLS; TRF4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 MBS1428582 COA    COA PDF
 Sequence Positions    462-542.. Fragment at the C-terminal ( Isoform 2).
 OMIM    605198
 3D Structure    ModBase 3D Structure for Q5XG87
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Homo sapiens (Human)
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PAPD7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar

Related Product Information for PAPD7 recombinant protein

   Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.
 Product Categories/Family for PAPD7 recombinant protein    Epigenetics and Nuclear Signaling
Section Bar
 SDS-PAGE of PAPD7 recombinant protein    PAPD7 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PAPD7. It may not necessarily be applicable to this product.
 NCBI GI #    284507293
 NCBI GeneID    11044
 NCBI Accession #    NP_001165276.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001171805.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q5XG87 [Other Products]
 UniProt Secondary Accession #    O43289; Q17RZ1; Q9Y6C1; A8K1E2; M1JCE6 [Other Products]
 UniProt Related Accession #    Q5XG87 [Other Products]
 Molecular Weight    59,874 Da
Table BarTOPTable Bar
 NCBI Official Full Name    non-canonical poly(A) RNA polymerase PAPD7 isoform 2
 NCBI Official Synonym Full Names    PAP associated domain containing 7
 NCBI Official Symbol    PAPD7 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    non-canonical poly(A) RNA polymerase PAPD7; non-canonical poly(A) RNA polymerase PAPD7; TUTase 5; DNA polymerase kappa; DNA polymerase sigma; terminal uridylyltransferase 5; polymerase (DNA directed) sigma; polymerase (DNA-directed) sigma; PAP-associated domain-containing protein 7; topoisomerase-related function protein 4-1; TRAMP-like complex polyadenylate polymerase
 UniProt Protein Name    Non-canonical poly(A) RNA polymerase PAPD7
 UniProt Synonym Protein Names   
DNA polymerase sigma; LAK-1; PAP-associated domain-containing protein 7; TRAMP-like complex polyadenylate polymerase; Terminal uridylyltransferase 5; TUTase 5; Topoisomerase-related function protein 4-1; TRF4-1
 UniProt Gene Name    PAPD7 [Similar Products]
 UniProt Synonym Gene Names    POLS; TRF4; TUTase 5; TRF4-1 [Similar Products]
 UniProt Entry Name    PAPD7_HUMAN
Section Bar
 NCBI Summary for PAPD7    The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]
Section Bar
 UniProt Comments for PAPD7    POLS: DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation. Belongs to the DNA polymerase type-B-like family.

Protein type: EC; DNA replication; DNA repair, damage; Transferase

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: polynucleotide adenylyltransferase activity; DNA binding; SMC protein binding; metal ion binding; DNA-directed DNA polymerase activity

Biological Process: response to drug; mitotic chromosome condensation; cell division; double-strand break repair; sister chromatid cohesion
Table BarTOPTable Bar
 Research Articles on PAPD7    1. These results suggest that PAPD7 l is the major and active isoform of PAPD7 expressed in cells.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with PAPD7 recombinant proteinDiseases associated with PAPD7 recombinant protein
 Products by Pathway  Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 TRAMP Complex Pathway antibodies  TRAMP Complex Pathway Diagram
 TRAMP Complex Pathway antibodies  TRAMP Complex Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >1 publications with PAPD7 and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with PAPD7 and Nervous System Diseases
Organs/Tissues associated with PAPD7 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with PAPD7 and Eye
 Brain Antibodies  >1 publications with PAPD7 and Brain
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions