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PAPD7 recombinant protein :: DNA polymerase sigma (PAPD7) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1428582
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $195 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,035 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,160 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,400 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,410 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,470 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,585 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,110 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,125 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,410 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,770 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA polymerase sigma (PAPD7), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human DNA polymerase sigma (PAPD7)

 Product Synonym Names    DNA polymerase sigma; EC=2.7.7.7; DNA polymerase kappa; LAK-1; PAP-associated domain-containing protein 7; Terminal uridylyltransferase 5; TUTase 5; Topoisomerase-related function protein 4-1; TRF4-1
 Product Gene Name   

PAPD7 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PAPD7; POLS; TRF4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1428582 COA    COA PDF
 Sequence Positions    1-542. Full length of Isoform 2
 Sequence    MSPCPEEAAM RREVVKRIET VVKDLWPTAD VQIFGSFSTG LYLPTSDIDL VVFGKWERPP LQLLEQALRK HNVAEPCSIK VLDKATVPII KLTDQETEVK VDISFNMETG VRAAEFIKNY MKKYSLLPYL ILVLKQFLLQ RDLNEVFTGG ISSYSLILMA ISFLQLHPRI DARRADENLG MLLVEFFELY GRNFNYLKTG IRIKEGGAYI AKEEIMKAMT SGYRPSMLCI EDPLLPGNDV GRSSYGAMQV KQVFDYAYIV LSHAVSPLAR SYPNRDAEST LGRIIKVTQE VIDYRRWIKE KWGSKAHPSP GMDSRIKIKE RIATCNGEQT QNREPESPYG QRLTLSLSSP QLLSSGSSAS SVSSLSGSDV DSDTPPCTTP SVYQFSLQAP APLMAGLPTA LPMPSGKPQP TTSRTLIMTT NNQTRFTIPP PTLGVAPVPC RQAGVEGTAS LKAVHHMSSP AIPSASPNPL SSPHLYHKQH NGMKLSMKGS HGHTQGGGYS SVGSGGVRPP VGNRGHHQYN RTGWRRKKHT HTRDSLPVSL SR
 OMIM    605198
 3D Structure    ModBase 3D Structure for Q5XG87
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PAPD7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PAPD7 recombinant protein

   Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation.
 Product Categories/Family for PAPD7 recombinant protein    Epigenetics and Nuclear Signaling
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 SDS-PAGE of PAPD7 recombinant protein    PAPD7 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PAPD7. It may not necessarily be applicable to this product.
 NCBI GI #    284507293
 NCBI GeneID    11044
 NCBI Accession #    NP_001165276.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001171805.1 [Other Products]
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 UniProt Primary Accession #    Q5XG87 [Other Products]
 UniProt Secondary Accession #    O43289; Q17RZ1; Q9Y6C1; A8K1E2; M1JCE6 [Other Products]
 UniProt Related Accession #    Q5XG87 [Other Products]
 Molecular Weight    59,874 Da
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 NCBI Official Full Name    non-canonical poly(A) RNA polymerase PAPD7 isoform 2
 NCBI Official Synonym Full Names    PAP associated domain containing 7
 NCBI Official Symbol    PAPD7 [Similar Products]
 NCBI Official Synonym Symbols   
LAK1; POLK; POLS; TRF4; LAK-1; TRF41; TRF4-1; TUTASE5
[Similar Products]
 NCBI Protein Information    non-canonical poly(A) RNA polymerase PAPD7; non-canonical poly(A) RNA polymerase PAPD7; TUTase 5; DNA polymerase kappa; DNA polymerase sigma; terminal uridylyltransferase 5; polymerase (DNA directed) sigma; polymerase (DNA-directed) sigma; PAP-associated domain-containing protein 7; topoisomerase-related function protein 4-1; TRAMP-like complex polyadenylate polymerase
 UniProt Protein Name    Non-canonical poly(A) RNA polymerase PAPD7
 UniProt Synonym Protein Names   
DNA polymerase sigma; LAK-1; PAP-associated domain-containing protein 7; TRAMP-like complex polyadenylate polymerase; Terminal uridylyltransferase 5; TUTase 5; Topoisomerase-related function protein 4-1; TRF4-1
 UniProt Gene Name    PAPD7 [Similar Products]
 UniProt Synonym Gene Names    POLS; TRF4; TUTase 5; TRF4-1 [Similar Products]
 UniProt Entry Name    PAPD7_HUMAN
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 NCBI Summary for PAPD7    The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]
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 UniProt Comments for PAPD7    POLS: DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation. Belongs to the DNA polymerase type-B-like family.

Protein type: EC 2.7.7.19; DNA replication; DNA repair, damage; Transferase

Chromosomal Location of Human Ortholog: 5p15

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: polynucleotide adenylyltransferase activity; DNA binding; SMC protein binding; metal ion binding; DNA-directed DNA polymerase activity

Biological Process: response to drug; mitotic chromosome condensation; cell division; double-strand break repair; sister chromatid cohesion
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 Research Articles on PAPD7    1. These results suggest that PAPD7 l is the major and active isoform of PAPD7 expressed in cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PAPD7 recombinant proteinDiseases associated with PAPD7 recombinant protein
 Products by Pathway  Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 TRAMP Complex Pathway antibodies  TRAMP Complex Pathway Diagram
 TRAMP Complex Pathway antibodies  TRAMP Complex Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >1 publications with PAPD7 and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with PAPD7 and Nervous System Diseases
Organs/Tissues associated with PAPD7 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with PAPD7 and Eye
 Brain Antibodies  >1 publications with PAPD7 and Brain
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