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ERCC5 recombinant protein :: DNA repair protein complementing XP-G cells Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS947980
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $145 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $205 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $325 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $520 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $850 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DNA repair protein complementing XP-G cells (ERCC5), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human DNA repair protein complementing XP-G cells

 Product Synonym Names    DNA excision repair protein ERCC-5; Xeroderma pigmentosum group G-complementing protein
 Product Gene Name   

ERCC5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    947-1186aa; Partial
 Sequence    SFLWGKPDLD KIREFCQRYF GWNRTKTDES LFPVLKQLDA QQTQLRIDSF FRLAQQEKED AKRIKSQRLN RAVTCMLRKE KEAAASEIEA VSVAMEKEFE LLDKAKGKTQ KRGITNTLEE SSSLKRKRLS DSKGKNTCGG FLGETCLSES SDGSSSEDAE SSSLMNVQRR TAAKEPKTSA SDSQNSVKEA PVKNGGATTS SSSDSDDDGG KEKMVLVTAR SVFGKKRRKL RRARGRKRKT
 OMIM    133530
 3D Structure    ModBase 3D Structure for P28715
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ERCC5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ERCC5 recombinant protein

   Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
 Product Categories/Family for ERCC5 recombinant protein    Epigenetics and Nuclear Signaling
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 SDS-PAGE of ERCC5 recombinant protein    ERCC5 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ERCC5. It may not necessarily be applicable to this product.
 NCBI GI #    51988900
 NCBI GeneID    2073
 NCBI Accession #    NP_000114.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000123.3 [Other Products]
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 UniProt Primary Accession #    P28715 [Other Products]
 UniProt Secondary Accession #    Q5JUS4; Q5JUS5; Q7Z2V3; Q8IZL6; Q8N1B7; Q9HD59; Q9HD60; A6NGT4 [Other Products]
 UniProt Related Accession #    P28715 [Other Products]
 Molecular Weight    30.95kd
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 NCBI Official Full Name    DNA repair protein complementing XP-G cells
 NCBI Official Synonym Full Names    excision repair cross-complementation group 5
 NCBI Official Symbol    ERCC5 [Similar Products]
 NCBI Official Synonym Symbols   
XPG; UVDR; XPGC; COFS3; ERCM2; ERCC5-201
[Similar Products]
 NCBI Protein Information    DNA repair protein complementing XP-G cells
 UniProt Protein Name    DNA repair protein complementing XP-G cells
 UniProt Synonym Protein Names   
DNA excision repair protein ERCC-5; Xeroderma pigmentosum group G-complementing protein
 Protein Family    DNA repair protein
 UniProt Gene Name    ERCC5 [Similar Products]
 UniProt Synonym Gene Names    ERCM2; XPG; XPGC [Similar Products]
 UniProt Entry Name    ERCC5_HUMAN
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 NCBI Summary for ERCC5    This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]
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 UniProt Comments for ERCC5    XPG: Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G); also known as xeroderma pigmentosum VII (XP7). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-G patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.-.-; DNA repair, damage; Deoxyribonuclease

Chromosomal Location of Human Ortholog: 13q33

Cellular Component: DNA replication factor A complex; DNA-directed RNA polymerase II, holoenzyme; holo TFIIH complex; nucleoplasm; nucleus

Molecular Function: bubble DNA binding; double-stranded DNA binding; endodeoxyribonuclease activity; metal ion binding; protein binding; protein homodimerization activity; protein N-terminus binding; single-stranded DNA binding

Biological Process: DNA repair; negative regulation of apoptosis; nucleotide-excision repair; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; response to UV; response to UV-C; transcription-coupled nucleotide-excision repair; UV protection

Disease: Xeroderma Pigmentosum, Complementation Group G
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Product References and Citations for ERCC5 recombinant protein

   "Complementation of the DNA repair defect in Xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2." Scherly D., Nouspikel T., Corlet J., Ucla C., Bairoch A., Clarkson S.G. Nature 363:182-185(1993)
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 Research Articles on ERCC5    1. the rs2296147 and rs2094258 polymorphisms of XPG, could be used as surrogate markers, leading to individualization of non-small cell lung cancer treatment strategies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ERCC5 recombinant proteinDiseases associated with ERCC5 recombinant protein
 Reference Product  PubMed Publications
 ERCC1 recombinant protein  >59 publications with ERCC5 and ERCC1
 ERCC2 recombinant protein  >58 publications with ERCC5 and ERCC2
 ERCC4 recombinant protein  >48 publications with ERCC5 and ERCC4
 XPC recombinant protein  >38 publications with ERCC5 and XPC
 XPA recombinant protein  >34 publications with ERCC5 and XPA
 ERCC6 recombinant protein  >20 publications with ERCC5 and ERCC6
 ERCC3 recombinant protein  >19 publications with ERCC5 and ERCC3
 RAD23B recombinant protein  >9 publications with ERCC5 and RAD23B
 PCNA recombinant protein  >6 publications with ERCC5 and PCNA
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >32 publications with ERCC5 and Carcinoma
 Lung Neoplasms Antibodies  >21 publications with ERCC5 and Lung Neoplasms
 Precancerous Conditions Antibodies  >11 publications with ERCC5 and Precancerous Conditions
 Adenocarcinoma Antibodies  >9 publications with ERCC5 and Adenocarcinoma
 Breast Neoplasms Antibodies  >9 publications with ERCC5 and Breast Neoplasms
 Chromosome Aberrations Antibodies  >7 publications with ERCC5 and Chromosome Aberrations
 Liver Neoplasms Antibodies  >6 publications with ERCC5 and Liver Neoplasms
 Ovarian Neoplasms Antibodies  >6 publications with ERCC5 and Ovarian Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with ERCC5 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >4 publications with ERCC5 and Cardiovascular Diseases
Organs/Tissues associated with ERCC5 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >25 publications with ERCC5 and Lung
 Blood Antibodies  >22 publications with ERCC5 and Blood
 Skin Antibodies  >9 publications with ERCC5 and Skin
 Liver Antibodies  >7 publications with ERCC5 and Liver
 Brain Antibodies  >7 publications with ERCC5 and Brain
 Bone Antibodies  >5 publications with ERCC5 and Bone
 Stomach Antibodies  >4 publications with ERCC5 and Stomach
 Heart Antibodies  >4 publications with ERCC5 and Heart
 Prostate Antibodies  >4 publications with ERCC5 and Prostate
 Eye Antibodies  >4 publications with ERCC5 and Eye
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