NM_032482.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA
NCBI Official Synonym Full Names
DOT1 like histone lysine methyltransferase
NCBI Official Synonym Symbols
NCBI Protein Information
histone-lysine N-methyltransferase, H3 lysine-79 specific
UniProt Protein Name
Histone-lysine N-methyltransferase, H3 lysine-79 specific
UniProt Synonym Protein Names
DOT1-like protein; Histone H3-K79 methyltransferase; H3-K79-HMTase; Lysine N-methyltransferase 4
UniProt Synonym Gene Names
NCBI Summary for DOT1L
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
UniProt Comments for DOT1L
DOT1L: a protein-lysine N-methyltransferase of the seven beta-strand class. Catalyzes the mono-, di- and tri-methylation of H3K79. Methylated H3K79 is associated with active gene transcription. DOT1L activity drives proliferation of mixed lineage leukemia 1 protein (MLL)-rearranged leukemias, inducing the aberrant transcription of a number of leukemogenic genes including HOXA9 and MEIS1. Binds to DNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus; protein complex
Molecular Function: histone lysine N-methyltransferase activity (H3-K79 specific); histone methyltransferase activity; histone-lysine N-methyltransferase activity; protein binding
Biological Process: chromatin silencing at telomere; DNA damage checkpoint; DNA repair; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of JAK-STAT cascade; telomere organization and biogenesis
Product References and Citations for DOT1L recombinant protein
1. Feng, Q., et al. Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol. 12 (12):1052-8, 2002. 2. Min, J., et al. Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. Cell. 112 (5):711-23, 2003. 3. Okada, Y., et al. hDOT1L links histone methylation to leukemo-genesis. Cell. 121 (2):167-78, 2005.
Research Articles on DOT1L
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Products associated with DOT1L recombinant protein
Pathways associated with DOT1L recombinant protein
Diseases associated with DOT1L recombinant protein
Organs/Tissues associated with DOT1L recombinant protein
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