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DPP4 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203255
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DPP4, Recombinant Protein

★Popular Item★
 Also Known As   

DPP4 (CD26), 39-766aa, Human,His tag, Baculovirus (Bioactivity Validated)

 Product Synonym Names    Dipeptidyl peptidase-4; DPPIV; ADABP; ADCP2; TP103; Dipeptidyl peptidase-4; DPP4; dipeptidyl-peptidase 4; CD26; dipeptidylpeptidase IV (CD26 adenosine deaminase complexing protein 2); adenosine deaminase complexing protein 2
 Product Gene Name   

DPP4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    ADPSRKTYTL TDYLKNTYRL KLYSLRWISD HEYLYKQENN ILVFNAEYGN SSVFLENSTF DEFGHSINDY SISPDGQFIL LEYNYVKQWR HSYTASYDIY DLNKRQLITE ERIPNNTQWV TWSPVGHKLA YVWNNDIYVK IEPNLPSYRI TWTGKEDIIY NGITDWVYEE EVFSAYSALW WSPNGTFLAY AQFNDTEVPL IEYSFYSDES LQYPKTVRVP YPKAGAVNPT VKFFVVNTDS LSSVTNATSI QITAPASMLI GDHYLCDVTW ATQERISLQW LRRIQNYSVM DICDYDESSG RWNCLVARQH IEMSTTGWVG RFRPSEPHFT LDGNSFYKII SNEEGYRHIC YFQIDKKDCT FITKGTWEVI GIEALTSDYL YYISNEYKGM PGGRNLYKIQ LSDYTKVTCL SCELNPERCQ YYSVSFSKEA KYYQLRCSGP GLPLYTLHSS VNDKGLRVLE DNSALDKMLQ NVQMPSKKLD FIILNETKFW YQMILPPHFD KSKKYPLLLD VYAGPCSQKA DTVFRLNWAT YLASTENIIV ASFDGRGSGY QGDKIMHAIN RRLGTFEVED QIEAARQFSK MGFVDNKRIA IWGWSYGGYV TSMVLGSGSG VFKCGIAVAP VSRWEYYDSV YTERYMGLPT PEDNLDHYRN STVMSRAENF KQVEYLLIHG TADDNVHFQQ SAQISKALVD VGVDFQAMWY TDEDHGIASS TAHQHIYTHM SHFIKQCFSL PHHHHHH
 OMIM    X60708 mRNA
 3D Structure    ModBase 3D Structure for P27487
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 Host    Baculovirus
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid in 20mM Tris-HCl pH 8.0, 100mM NaCl, 1mM EDTA, 10% glycerol
 Concentration    0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
 Biological Activity    Specific activity is > 200 units/mg, One unit produces 1.0 umole of p-Nitroaniline from Gly-Pro- p-Nitroaniline per minute at pH 8.0 at 37C.
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of DPP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DPP4 recombinant protein

   DPP4, dipeptidyl peptidase-4 is a complex enzyme expressed on the surface of most cell types and is a serine exopeptidase that cleaves x-proline dipeptides from the N-terminus of polypeptides. DPP4 protein is associated with intracellular signal transduction, apoptosis and plays an important role in tumor biology. There are at least 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuro peptides. Furthermore, DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Recombinant human DPP4 protein was expressed with c-terminal His-tag in high-5 cells using baculovirus expression system and purified by using conventional chromatography techniques.
 Product Categories/Family for DPP4 recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for DPP4 recombinant protein   

SDS-PAGE

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 SDS-Page of DPP4 recombinant protein    DPP4 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for DPP4. It may not necessarily be applicable to this product.
 NCBI GI #    18765694
 NCBI GeneID    1803
 NCBI Accession #    NP_001926 [Other Products]
 NCBI GenBank Nucleotide #    NM_001935.3 [Other Products]
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 UniProt Primary Accession #    P27487 [Other Products]
 UniProt Secondary Accession #    Q53TN1 [Other Products]
 UniProt Related Accession #    P27487 [Other Products]
 Molecular Weight    85.4kDa (737aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    dipeptidyl peptidase 4
 NCBI Official Synonym Full Names    dipeptidyl peptidase 4
 NCBI Official Symbol    DPP4 [Similar Products]
 NCBI Official Synonym Symbols   
CD26; ADABP; ADCP2; DPPIV; TP103
[Similar Products]
 NCBI Protein Information    dipeptidyl peptidase 4
 UniProt Protein Name    Dipeptidyl peptidase 4
 UniProt Synonym Protein Names   
ADABP; Adenosine deaminase complexing protein 2; ADCP-2
 Protein Family    Dipeptidyl peptidase
 UniProt Gene Name    DPP4 [Similar Products]
 UniProt Synonym Gene Names    ADCP2; CD26; ADCP-2; DPP IV [Similar Products]
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 NCBI Summary for DPP4    The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DPP4    Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
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Product References and Citations for DPP4 recombinant protein

   Pratley RE and Salsali A. (2007) Curr Med Res Opin. 23 (4):919-31; Rosenstock J. and Zinman B. (2007) Curr Opin Endocrino Diabetes Obes.60 (11):1454-70; Barnett A. (2006). J.Clin. Pract. 60 (11):1454-70;
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 Research Articles on DPP4    1. As for 18Lin(-), CD34(-) HSCs are characterized by low expression of the tetraspanin CD9, which promotes homing, and high expression of the peptidase CD26, which inhibits homing.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DPP4 recombinant proteinPathways associated with DPP4 recombinant protein
 Reference Product  PubMed Publications
 GIP recombinant protein  >77 publications with DPP4 and GIP
 GLP1R recombinant protein  >71 publications with DPP4 and GLP1R
 ADA recombinant protein  >27 publications with DPP4 and ADA
 GCG recombinant protein  >5 publications with DPP4 and GCG
 ACE2 recombinant protein  >3 publications with DPP4 and ACE2
 XPNPEP2 recombinant protein  >1 publications with DPP4 and XPNPEP2
 PRCP recombinant protein  >1 publications with DPP4 and PRCP
 Products by Pathway  Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway Diagram
 Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram
Diseases associated with DPP4 recombinant proteinOrgans/Tissues associated with DPP4 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >190 publications with DPP4 and Cardiovascular Diseases
 Inflammation Antibodies  >133 publications with DPP4 and Inflammation
 Insulin Resistance Antibodies  >113 publications with DPP4 and Insulin Resistance
 Hyperglycemia Antibodies  >97 publications with DPP4 and Hyperglycemia
 Heart Diseases Antibodies  >88 publications with DPP4 and Heart Diseases
 Liver Diseases Antibodies  >57 publications with DPP4 and Liver Diseases
 Weight Loss Antibodies  >56 publications with DPP4 and Weight Loss
 Kidney Diseases Antibodies  >55 publications with DPP4 and Kidney Diseases
 Weight Gain Antibodies  >55 publications with DPP4 and Weight Gain
 Fibrosis Antibodies  >46 publications with DPP4 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >609 publications with DPP4 and Blood
 Heart Antibodies  >139 publications with DPP4 and Heart
 Vascular Antibodies  >112 publications with DPP4 and Vascular
 Pancreas Antibodies  >107 publications with DPP4 and Pancreas
 Liver Antibodies  >105 publications with DPP4 and Liver
 Kidney Antibodies  >98 publications with DPP4 and Kidney
 Lung Antibodies  >73 publications with DPP4 and Lung
 Muscle Antibodies  >59 publications with DPP4 and Muscle
 Bone Antibodies  >55 publications with DPP4 and Bone
 Brain Antibodies  >51 publications with DPP4 and Brain
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