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DSCR1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203113
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DSCR1, Recombinant Protein

 Also Known As   

DSCR1 isoform b, 1-117aa, Human, E Coli

 Product Synonym Names    Down syndrome candidate region 1; Down syndrome candidate region 1; Down syndrome critical region protein 1; adapt78 protein; calcipressin 1; Calcipressin 1 isoform b; Down syndrome candidate region 1
 Product Gene Name   

DSCR1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
 OMIM    U28833 mRNA
 3D Structure    ModBase 3D Structure for P53805
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    In 20mM Tris 7.5, 0.1M NaCl, 1mM DTT
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of DSCR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DSCR1 recombinant protein

   The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for DSCR1 recombinant protein    Neuroscience
 Applications Tested/Suitable for DSCR1 recombinant protein   

SDS-PAGE

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 SDS-Page of DSCR1 recombinant protein    DSCR1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for DSCR1. It may not necessarily be applicable to this product.
 NCBI GI #    44680108
 NCBI GeneID    1827
 NCBI Accession #    NP_981962 [Other Products]
 NCBI GenBank Nucleotide #    NM_203417.2 [Other Products]
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 UniProt Primary Accession #    P53805 [Other Products]
 UniProt Secondary Accession #    O00582; O00583; Q53XT0; Q6IBC6; Q7Z555; Q96R03; Q9BU69; Q9UF15; Q9UME4; D3DSF9 [Other Products]
 UniProt Related Accession #    P53805 [Other Products]
 Molecular Weight    13kDa (117aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    calcipressin-1 isoform b
 NCBI Official Synonym Full Names    regulator of calcineurin 1
 NCBI Official Symbol    RCAN1 [Similar Products]
 NCBI Official Synonym Symbols   
CSP1; DSC1; RCN1; DSCR1; MCIP1; ADAPT78
[Similar Products]
 NCBI Protein Information    calcipressin-1
 UniProt Protein Name    Calcipressin-1
 UniProt Synonym Protein Names   
Adapt78; Down syndrome critical region protein 1; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
 UniProt Gene Name    RCAN1 [Similar Products]
 UniProt Synonym Gene Names    ADAPT78; CSP1; DSC1; DSCR1; MCIP1 [Similar Products]
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 NCBI Summary for DSCR1    The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
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 UniProt Comments for DSCR1    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
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Product References and Citations for DSCR1 recombinant protein

   Hesser BA., et al. (2004) Blood. 104 (1):149-58; Harris CD., et al. (2007) FEBS J. 274 (7):1715-24.;
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 Research Articles on DSCR1    1. Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DSCR1 recombinant proteinPathways associated with DSCR1 recombinant protein
 Reference Product  PubMed Publications
 DYRK1A recombinant protein  >18 publications with DSCR1 and DYRK1A
 NFATC1 recombinant protein  >14 publications with DSCR1 and NFATC1
 CABIN1 recombinant protein  >2 publications with DSCR1 and CABIN1
 PPP3CA recombinant protein  >1 publications with DSCR1 and PPP3CA
 Products by Pathway  Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 Oxytocin Signaling Pathway antibodies  Oxytocin Signaling Pathway Diagram
 Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway antibodies  Role Of Calcineurin-dependent NFAT Signaling In Lymphocytes Pathway Diagram
 Thyroid Hormone Signaling Pathway antibodies  Thyroid Hormone Signaling Pathway Diagram
Diseases associated with DSCR1 recombinant proteinOrgans/Tissues associated with DSCR1 recombinant protein
 Disease Name  Pubmed Publications
 Down Syndrome Antibodies  >140 publications with DSCR1 and Down Syndrome
 Nervous System Diseases Antibodies  >99 publications with DSCR1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >46 publications with DSCR1 and Cardiovascular Diseases
 Hypertrophy Antibodies  >42 publications with DSCR1 and Hypertrophy
 Heart Diseases Antibodies  >38 publications with DSCR1 and Heart Diseases
 Disease Models, Animal Antibodies  >31 publications with DSCR1 and Disease Models, Animal
 Inflammation Antibodies  >28 publications with DSCR1 and Inflammation
 Heart Defects, Congenital Antibodies  >11 publications with DSCR1 and Heart Defects, Congenital
 Necrosis Antibodies  >10 publications with DSCR1 and Necrosis
 Learning Disorders Antibodies  >8 publications with DSCR1 and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >257 publications with DSCR1 and Muscle
 Brain Antibodies  >75 publications with DSCR1 and Brain
 Heart Antibodies  >66 publications with DSCR1 and Heart
 Vascular Antibodies  >45 publications with DSCR1 and Vascular
 Blood Antibodies  >33 publications with DSCR1 and Blood
 Nerve Antibodies  >15 publications with DSCR1 and Nerve
 Bone Antibodies  >13 publications with DSCR1 and Bone
 Embryonic Tissue Antibodies  >12 publications with DSCR1 and Embryonic Tissue
 Lung Antibodies  >12 publications with DSCR1 and Lung
 Kidney Antibodies  >10 publications with DSCR1 and Kidney
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