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DSTN recombinant protein

Scan QR to view Datasheet Catalog #    MBS204618
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DSTN, Recombinant Protein

★Popular Item★
 Also Known As   

DSTN, 1-165aa, Human, His tag, E Coli

 Product Synonym Names    Destrin (actin depolymerizing factor); ACTDP; ADF; bA462D18.2
 Product Gene Name   

DSTN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MASGVQVADE VCRIFYDMKV RKCSTPEEIK KRKKAVIFCL SADKKCIIVE EGKEILVGDV GVTITDPFKH FVGMLPEKDC RYALYDASFE TKESRKEELM FFLWAPELAP LKSKMIYASS KDAIKKKFQG IKHECQANGP EDLNRACIAE KLGGSLIVAF EGCPVLEHHH HHH
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of DSTN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for DSTN recombinant protein

   Destrin (actin depolymerizing factor), also known as DSTN, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. DSTN is a small phosphoinositide-sensitive actin-binding protein capable of depolymerizing actin-filaments in vitro. It is found in various epithelial and endothelial cells but is practically absent from adult mouse heart and skeletal muscle cells. DSTN shares 71% sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. Recombinant human DSTN protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for DSTN recombinant protein    Actin & Myosin Related
 Applications Tested/Suitable for DSTN recombinant protein   

SDS-PAGE

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 SDS-PAGE of DSTN recombinant protein    DSTN recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for DSTN. It may not necessarily be applicable to this product.
 NCBI GI #    5802966
 NCBI GeneID    11034
 NCBI Accession #    NP_006861 [Other Products]
 NCBI GenBank Nucleotide #    NM_006870.3 [Other Products]
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 UniProt Secondary Accession #    P18282; Q5W166; Q6IAW2; B2R6N2; B4DYA6 [Other Products]
 UniProt Related Accession #    P60981 [Other Products]
 Molecular Weight    19.5 kDa (173aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    destrin isoform a
 NCBI Official Synonym Full Names    destrin (actin depolymerizing factor)
 NCBI Official Symbol    DSTN [Similar Products]
 NCBI Official Synonym Symbols   
ADF; ACTDP; HEL32; bA462D18.2
[Similar Products]
 NCBI Protein Information    destrin; actin-depolymerizing factor; bA462D18.2 (destrin (actin depolymerizing factor ADF) (ACTDP)); epididymis luminal protein 32
 UniProt Protein Name    Destrin
 UniProt Synonym Protein Names   
Actin-depolymerizing factor; ADF
 Protein Family    Destrin
 UniProt Gene Name    DSTN [Similar Products]
 UniProt Synonym Gene Names    ACTDP; DSN; ADF [Similar Products]
 UniProt Entry Name    DEST_HUMAN
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 NCBI Summary for DSTN    The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DSTN    Destrin: an actin-depolymerizing cytoskeletal protein that belongs to the ADF actin-binding protein family. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Present in many vertebrate tissues and particularly abundant in neuronal cells. It binds F-actin in a pH-dependent manner which affects it's severing/depolymerizing activities. It also binds G-actin at pH 8.0 thereby sequestering monomers and preventing polymerization.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 20p12.1

Cellular Component: cortical actin cytoskeleton; actin cytoskeleton

Molecular Function: actin binding

Biological Process: actin filament severing; actin filament depolymerization; positive regulation of actin filament depolymerization; actin polymerization and/or depolymerization
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Product References and Citations for DSTN recombinant protein

   Nishida E., et al. (1985) Biochemistry. 24:6624-6630.
Kanamori T., et al. (1995) J Biol Chem. 270: 8061-8067.
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 Research Articles on DSTN    1. Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DSTN recombinant proteinPathways associated with DSTN recombinant protein
 Reference Product  PubMed Publications
 SSH1 recombinant protein  >2 publications with DSTN and SSH1
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
Diseases associated with DSTN recombinant proteinOrgans/Tissues associated with DSTN recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with DSTN and Inflammation
 Congenital Abnormalities Antibodies  >5 publications with DSTN and Congenital Abnormalities
 Kidney Diseases Antibodies  >2 publications with DSTN and Kidney Diseases
 Neoplasm Metastasis Antibodies  >2 publications with DSTN and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >2 publications with DSTN and Disease Models, Animal
 Prostatic Diseases Antibodies  >2 publications with DSTN and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >2 publications with DSTN and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with DSTN and Cardiovascular Diseases
 Glioblastoma Antibodies  >1 publications with DSTN and Glioblastoma
 Infertility, Female Antibodies  >1 publications with DSTN and Infertility, Female
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with DSTN and Brain
 Nerve Antibodies  >9 publications with DSTN and Nerve
 Muscle Antibodies  >8 publications with DSTN and Muscle
 Eye Antibodies  >7 publications with DSTN and Eye
 Kidney Antibodies  >4 publications with DSTN and Kidney
 Embryonic Tissue Antibodies  >4 publications with DSTN and Embryonic Tissue
 Testis Antibodies  >3 publications with DSTN and Testis
 Prostate Antibodies  >2 publications with DSTN and Prostate
 Bone Antibodies  >2 publications with DSTN and Bone
 Stomach Antibodies  >1 publications with DSTN and Stomach
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