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DCN recombinant protein :: Decorin (DCN) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS956778 DCN recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $735 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $860 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $990 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,085 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,155 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,240 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,260 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,305 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,540 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,815 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,880 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,985 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,415 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Decorin (DCN), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Decorin (DCN)

 Product Synonym Names    Decorin; Bone proteoglycan II; PG-S2; PG40
 Product Gene Name   

DCN recombinant protein

[Similar Products]
 Product Synonym Gene Name    DCN; SLRR1B [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    31-359aa; Full length protein
 Sequence    DEASGIGPEV PDDRDFEPSL GPVCPFRCQC HLRVVQCSDL GLDKVPKDLP PDTTLLDLQN NKITEIKDGD FKNLKNLHAL ILVNNKISKV SPGAFTPLVK LERLYLSKNQ LKELPEKMPK TLQELRAHEN EITKVRKVTF NGLNQMIVIE LGTNPLKSSG IENGAFQGMK KLSYIRIADT NITSIPQGLP PSLTELHLDG NKISRVDAAS LKGLNNLAKL GLSFNSISAV DNGSLANTPH LRELHLDNNK LTRVPGGLAE HKYIQVVYLH NNNISVVGSS DFCPPGHNTK KASYSGVSLF SNPVQYWEIQ PSTFRCVYVR SAIQLGNYK
 OMIM    gene 610048
 3D Structure    ModBase 3D Structure for P07585
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DCN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for DCN recombinant protein

   May affect the rate of fibrils formation.
NCBI/Uniprot data below describe general gene information for DCN. It may not necessarily be applicable to this product.
 NCBI GI #    4503271
 NCBI GeneID    1634
 NCBI Accession #    NP_001911.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001920.3 [Other Products]
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 UniProt Primary Accession #    P07585 [Other Products]
 UniProt Secondary Accession #    Q9P0Z0; Q9P0Z1; Q9Y5N8; Q9Y5N9 [Other Products]
 UniProt Related Accession #    P07585 [Other Products]
 Molecular Weight    8,266 Da
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 NCBI Official Full Name    decorin isoform a preproprotein
 NCBI Official Synonym Full Names    decorin
 NCBI Official Symbol    DCN [Similar Products]
 NCBI Official Synonym Symbols   
CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
[Similar Products]
 NCBI Protein Information    decorin; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II
 UniProt Protein Name    Decorin
 UniProt Synonym Protein Names   
Bone proteoglycan II; PG-S2; PG40
 Protein Family    Decorin
 UniProt Gene Name    DCN [Similar Products]
 UniProt Synonym Gene Names    SLRR1B [Similar Products]
 UniProt Entry Name    PGS2_HUMAN
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 NCBI Summary for DCN    The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DCN    DCN: May affect the rate of fibrils formation. Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD). Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; lysosomal lumen; extracellular space; Golgi lumen; extracellular region; collagen type VI

Molecular Function: collagen binding; glycosaminoglycan binding; extracellular matrix binding; protein N-terminus binding

Biological Process: extracellular matrix organization and biogenesis; skeletal muscle development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; wound healing; response to lipopolysaccharide; pathogenesis; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; extracellular matrix disassembly; organ morphogenesis; response to mechanical stimulus; carbohydrate metabolic process; chondroitin sulfate catabolic process; kidney development; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; aging; placenta development

Disease: Corneal Dystrophy, Congenital Stromal
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 Research Articles on DCN    1. we identified the methylated +58CpG in DCN 5'-UTR associated with reduced expression of DCN mRNA, thereby downregulating E-cadherin in NSCLC cells with high metastatic potential.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DCN recombinant proteinPathways associated with DCN recombinant protein
 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >82 publications with DCN and TGFB1
 VCAN recombinant protein  >70 publications with DCN and VCAN
 EGFR recombinant protein  >19 publications with DCN and EGFR
 TGFB2 recombinant protein  >10 publications with DCN and TGFB2
 THBS1 recombinant protein  >6 publications with DCN and THBS1
 FBN1 recombinant protein  >4 publications with DCN and FBN1
 FN1 recombinant protein  >4 publications with DCN and FN1
 DPT recombinant protein  >3 publications with DCN and DPT
 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies  Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram
Diseases associated with DCN recombinant proteinOrgans/Tissues associated with DCN recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >307 publications with DCN and Nervous System Diseases
 Neoplasms Antibodies  >169 publications with DCN and Neoplasms
 Cardiovascular Diseases Antibodies  >163 publications with DCN and Cardiovascular Diseases
 Brain Diseases Antibodies  >157 publications with DCN and Brain Diseases
 Fibrosis Antibodies  >112 publications with DCN and Fibrosis
 Carcinoma Antibodies  >67 publications with DCN and Carcinoma
 Inflammation Antibodies  >51 publications with DCN and Inflammation
 Kidney Diseases Antibodies  >46 publications with DCN and Kidney Diseases
 Neoplasms, Experimental Antibodies  >23 publications with DCN and Neoplasms, Experimental
 Necrosis Antibodies  >22 publications with DCN and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >662 publications with DCN and Brain
 Nerve Antibodies  >285 publications with DCN and Nerve
 Connective Tissue Antibodies  >164 publications with DCN and Connective Tissue
 Skin Antibodies  >161 publications with DCN and Skin
 Bone Antibodies  >144 publications with DCN and Bone
 Muscle Antibodies  >144 publications with DCN and Muscle
 Vascular Antibodies  >125 publications with DCN and Vascular
 Ear Antibodies  >85 publications with DCN and Ear
 Kidney Antibodies  >80 publications with DCN and Kidney
 Lung Antibodies  >63 publications with DCN and Lung
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