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DEFa5 recombinant protein :: Defensin Alpha 5, Paneth Cell Specific (DEFa5) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010028 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $265 +1 FREE 8GB USB
0.1 mg  /  $415 +1 FREE 8GB USB
0.2 mg  /  $510 +1 FREE 8GB USB
0.5 mg  /  $990 +1 FREE 8GB USB
1 mg  /  $1,465 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Defensin Alpha 5, Paneth Cell Specific (DEFa5), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Defensin Alpha 5, Paneth Cell Specific (DEFa5)

 Product Gene Name   

DEFa5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.10 (6912829..6914259, complement). Location: 8p23.1
 OMIM    600472
 3D Structure    ModBase 3D Structure for Q01523
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 Host    E.coli
 Species Reactivity    Human
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 Purity/Purification    >92%
 Form/Format    PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
 Concentration    200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Glu20~Arg94
 Tags    N-terminal His-Tag
 Tissue Specificity    Intestine
 Subcellular Location    Secreted. Cytoplasmic vesicle, secretory vesicle
 Traits    Freeze-dried powder
    
 Predicted isoelectric point    5.9
 Predicted Molecular Mass    14.8kDa
 Accurate Molecular Mass    15kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
    
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of DEFa5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for DEFa5 recombinant protein   

SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.

(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of DEFa5 recombinant protein    DEFa5 recombinant protein Sequence image
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 Gene sequence (extract) of DEFa5 recombinant protein    DEFa5 recombinant protein Gene sequence (extract) image
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 SDS-PAGE of DEFa5 recombinant protein    DEFa5 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for DEFa5. It may not necessarily be applicable to this product.
 NCBI GI #    10337585
 NCBI GeneID    1670
 NCBI Accession #    NP_066290.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021010.1 [Other Products]
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 UniProt Primary Accession #    Q01523 [Other Products]
 UniProt Secondary Accession #    Q3KNV2; A0JDY6 [Other Products]
 UniProt Related Accession #    Q01523 [Other Products]
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 NCBI Official Full Name    defensin-5 preproprotein
 NCBI Official Synonym Full Names    defensin, alpha 5, Paneth cell-specific
 NCBI Official Symbol    DEFA5 [Similar Products]
 NCBI Official Synonym Symbols   
DEF5; HD-5
[Similar Products]
 NCBI Protein Information    defensin-5; HD5(20-94); defensin 5; defensin, alpha 5, preproprotein
 UniProt Protein Name    Defensin-5
 UniProt Synonym Protein Names   
Defensin, alpha 5; HD5(20-94)
 Protein Family    Defensin
 UniProt Gene Name    DEFA5 [Similar Products]
 UniProt Synonym Gene Names    DEF5 [Similar Products]
 UniProt Entry Name    DEF5_HUMAN
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 NCBI Summary for DEFa5    Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]
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 UniProt Comments for DEFa5    DEFA5: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Belongs to the alpha-defensin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: extracellular space; transport vesicle; Golgi lumen; extracellular region

Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus
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 Research Articles on DEFa5    1. human alpha defensin 5 increases LGR stem cell migration into wound beds, leading to enhanced healing, bacterial reduction, and hair production through the augmentation of key Wnt and wound healing transcripts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DEFa5 recombinant proteinPathways associated with DEFa5 recombinant protein
 Reference Product  PubMed Publications
 DEFA6 recombinant protein  >11 publications with DEFa5 and DEFA6
 NOD2 recombinant protein  >4 publications with DEFa5 and NOD2
 DEFB1 recombinant protein  >3 publications with DEFa5 and DEFB1
 DEFA4 recombinant protein  >2 publications with DEFa5 and DEFA4
 CAMP recombinant protein  >1 publications with DEFa5 and CAMP
 Products by Pathway  Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
Diseases associated with DEFa5 recombinant proteinOrgans/Tissues associated with DEFa5 recombinant protein
 Disease Name  Pubmed Publications
 Inflammatory Bowel Diseases Antibodies  >9 publications with DEFa5 and Inflammatory Bowel Diseases
 Colonic Diseases Antibodies  >6 publications with DEFa5 and Colonic Diseases
 Colitis Antibodies  >6 publications with DEFa5 and Colitis
 Colitis, Ulcerative Antibodies  >5 publications with DEFa5 and Colitis, Ulcerative
 Inflammation Antibodies  >4 publications with DEFa5 and Inflammation
 Necrosis Antibodies  >1 publications with DEFa5 and Necrosis
 Colonic Neoplasms Antibodies  >1 publications with DEFa5 and Colonic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >12 publications with DEFa5 and Intestine
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