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DNASE1L3 recombinant protein :: Deoxyribonuclease gamma (DNASE1L3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS9423895 DNASE1L3 recombinant protein
Unit / Price
0.01 mg  /  $200 +1 FREE 8GB USB
0.05 mg  /  $380 +1 FREE 8GB USB
0.1 mg  /  $610 +1 FREE 8GB USB
0.2 mg  /  $960 +1 FREE 8GB USB
0.5 mg  /  $1,570 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Deoxyribonuclease gamma (DNASE1L3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Deoxyribonuclease gamma (DNASE1L3)

 Product Synonym Names    DNase I homolog protein DHP2
 Product Gene Name   

DNASE1L3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    Full Length, 21-305aa
 OMIM    U56814 mRNA
 3D Structure    ModBase 3D Structure for Q13609
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 Host    E Coli
 Species Reactivity    Human
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Tris-based buffer, 50% glycerol
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 Tag Info    N-terminal GST-tagged
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 Preparation and Storage    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.
 Other Notes    Small volumes of DNASE1L3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DNASE1L3 recombinant protein

   Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.
NCBI/Uniprot data below describe general gene information for DNASE1L3. It may not necessarily be applicable to this product.
 NCBI GI #    375151549
 NCBI GeneID    1776
 NCBI Accession #    NP_001243489.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256560.1 [Other Products]
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 UniProt Primary Accession #    Q13609 [Other Products]
 UniProt Secondary Accession #    O75803; B2R8B1; B7Z707 [Other Products]
 UniProt Related Accession #    Q13609 [Other Products]
 Molecular Weight    60.04 kDa
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 NCBI Official Full Name    deoxyribonuclease gamma isoform 2
 NCBI Official Synonym Full Names    deoxyribonuclease 1 like 3
 NCBI Official Symbol    DNASE1L3 [Similar Products]
 NCBI Official Synonym Symbols   
LSD; DHP2; SLEB16; DNAS1L3
[Similar Products]
 NCBI Protein Information    deoxyribonuclease gamma
 UniProt Protein Name    Deoxyribonuclease gamma
 UniProt Synonym Protein Names   
DNase I homolog protein DHP2; Deoxyribonuclease I-like 3; DNase I-like 3; Liver and spleen DNase; LS-DNase; LSD
 Protein Family    Deoxyribonuclease
 UniProt Gene Name    DNASE1L3 [Similar Products]
 UniProt Synonym Gene Names    DHP2; DNAS1L3; DNase gamma; DNase I-like 3; LS-DNase; LSD [Similar Products]
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 NCBI Summary for DNASE1L3    This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for DNASE1L3    DNASE1L3: Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units. Defects in DNASE1L3 are the cause of systemic lupus erythematosus type 16 (SLEB16). A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Belongs to the DNase I family.

Protein type: Apoptosis; Calcium-binding; Deoxyribonuclease; EC 3.1.21.-; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: endoplasmic reticulum; nucleus

Molecular Function: calcium ion binding; deoxyribonuclease activity

Biological Process: DNA fragmentation during apoptosis; DNA metabolic process

Disease: Systemic Lupus Erythematosus 16
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 Research Articles on DNASE1L3    1. Single nucleotide polymorphisms producing a loss-of-function variant of the enzymes in DNASE1, DNASE1L3, and DNASE2, possibly serving as a genetic risk factor for autoimmune diseases, were confirmed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with DNASE1L3 recombinant proteinOrgans/Tissues associated with DNASE1L3 recombinant protein
 Disease Name  Pubmed Publications
 Death Antibodies  >6 publications with DNASE1L3 and Death
 Lupus Erythematosus, Systemic Antibodies  >5 publications with DNASE1L3 and Lupus Erythematosus, Systemic
 Carcinoma Antibodies  >2 publications with DNASE1L3 and Carcinoma
 Cardiovascular Diseases Antibodies  >2 publications with DNASE1L3 and Cardiovascular Diseases
 Brain Diseases Antibodies  >1 publications with DNASE1L3 and Brain Diseases
 Inflammation Antibodies  >1 publications with DNASE1L3 and Inflammation
 Necrosis Antibodies  >1 publications with DNASE1L3 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with DNASE1L3 and Liver
 Eye Antibodies  >1 publications with DNASE1L3 and Eye
 Brain Antibodies  >1 publications with DNASE1L3 and Brain
 Spleen Antibodies  >1 publications with DNASE1L3 and Spleen
 Kidney Antibodies  >1 publications with DNASE1L3 and Kidney
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