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Dnase1l3 recombinant protein :: Deoxyribonuclease gamma (Dnase1l3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1075400 Dnase1l3 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $690 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $925 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $965 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,015 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,105 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,205 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,215 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,250 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,440 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,755 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,830 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,895 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,335 +2 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Deoxyribonuclease gamma (Dnase1l3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat Deoxyribonuclease gamma (Dnase1l3)

 Product Gene Name   

Dnase1l3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1075400 COA    COA PDF
 Sequence Positions    26-310aa, Full Length of Mature Protein
 3D Structure    ModBase 3D Structure for O89107
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Dnase1l3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Dnase1l3 recombinant protein

   This gene encodes a member of the DNase family. The protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
NCBI/Uniprot data below describe general gene information for Dnase1l3. It may not necessarily be applicable to this product.
 NCBI GI #    16758784
 NCBI GeneID    116687
 NCBI Accession #    NP_446359.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053907.1 [Other Products]
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 UniProt Primary Accession #    O89107 [Other Products]
 UniProt Related Accession #    O89107 [Other Products]
 Molecular Weight    35,708 Da
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 NCBI Official Full Name    deoxyribonuclease gamma
 NCBI Official Synonym Full Names    deoxyribonuclease 1-like 3
 NCBI Official Symbol    Dnase1l3 [Similar Products]
 NCBI Protein Information    deoxyribonuclease gamma
 UniProt Protein Name    Deoxyribonuclease gamma
 UniProt Synonym Protein Names   
DNaseY; Deoxyribonuclease I-like 3; DNase I-like 3
 Protein Family    Deoxyribonuclease
 UniProt Gene Name    Dnase1l3 [Similar Products]
 UniProt Synonym Gene Names    DNase gamma; DNase I-like 3 [Similar Products]
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 NCBI Summary for Dnase1l3    Ca2+/Mg2+ dependent endonuclease that catalyzes cleavage of both single and double stranded DNA; may play a role in apoptotic DNA fragmentation [RGD, Feb 2006]
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 UniProt Comments for Dnase1l3    Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (PubMed:7957253). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation ().
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 Research Articles on Dnase1l3    1. DNase gamma is suggested to be involved in naturally occurring apoptosis in developing nervous systems
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Dnase1l3 recombinant proteinDiseases associated with Dnase1l3 recombinant protein
 Reference Product  PubMed Publications
 Pxk recombinant protein  >1 publications with Dnase1l3 and Pxk
 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >5 publications with Dnase1l3 and Lupus Erythematosus, Systemic
 Cardiovascular Diseases Antibodies  >2 publications with Dnase1l3 and Cardiovascular Diseases
 Brain Diseases Antibodies  >1 publications with Dnase1l3 and Brain Diseases
 Inflammation Antibodies  >1 publications with Dnase1l3 and Inflammation
 Necrosis Antibodies  >1 publications with Dnase1l3 and Necrosis
Organs/Tissues associated with Dnase1l3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with Dnase1l3 and Liver
 Eye Antibodies  >1 publications with Dnase1l3 and Eye
 Ovary Antibodies  >1 publications with Dnase1l3 and Ovary
 Spleen Antibodies  >1 publications with Dnase1l3 and Spleen
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