NP_001934.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 32.7kDa Accurate Molecular Mass: 38kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
desmoglein-2 preproprotein
NCBI Official Synonym Full Names
desmoglein 2
NCBI Official Synonym Symbols
NCBI Protein Information
desmoglein-2
UniProt Protein Name
Desmoglein-2
UniProt Synonym Protein Names
Cadherin family member 5; HDGC
UniProt Synonym Gene Names
UniProt Entry Name
DSG2_HUMAN
NCBI Summary for DSG2
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq, Jan 2016]
UniProt Comments for DSG2
DSG2: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10); also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB). A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Protein type: Calcium-binding; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: apical plasma membrane; cell surface; desmosome; integral to membrane; intercellular junction; lateral plasma membrane; plasma membrane
Molecular Function: calcium ion binding; cell adhesion molecule binding
Biological Process: apoptosis; cell adhesion; cell structure disassembly during apoptosis; homophilic cell adhesion; maternal process involved in pregnancy; programmed cell death; response to progesterone stimulus
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 10; Cardiomyopathy, Dilated, 1bb
Research Articles on DSG2
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Products associated with DSG2 recombinant protein
Pathways associated with DSG2 recombinant protein
Diseases associated with DSG2 recombinant protein
Disease Name |
Pubmed Publications |
Heart Defects, Congenital Antibodies |
>56 publications with DSG2 and Heart Defects, Congenital |
Disease Models, Animal Antibodies |
>8 publications with DSG2 and Disease Models, Animal |
Necrosis Antibodies |
>8 publications with DSG2 and Necrosis |
Neoplasms, Experimental Antibodies |
>7 publications with DSG2 and Neoplasms, Experimental |
Inflammation Antibodies |
>6 publications with DSG2 and Inflammation |
Neoplasm Metastasis Antibodies |
>6 publications with DSG2 and Neoplasm Metastasis |
Breast Neoplasms Antibodies |
>5 publications with DSG2 and Breast Neoplasms |
Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 Antibodies |
>5 publications with DSG2 and Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 |
Fibrosis Antibodies |
>4 publications with DSG2 and Fibrosis |
Hypertrophy Antibodies |
>4 publications with DSG2 and Hypertrophy |
Organs/Tissues associated with DSG2 recombinant protein
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