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DSP recombinant protein :: Desmoplakin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS949399
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $915 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,155 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,155 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,665 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,760 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,225 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Desmoplakin (DSP), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Desmoplakin

 Product Synonym Names    250/210 kDa paraneoplastic pemphigus antigen
 Product Gene Name   

DSP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS949399 COA    COA PDF
 Sequence Positions    78-300. Partial
 Sequence    CSDCLMRAEL IVQPELKYGD GIQLTRSREL DECFAQANDQ MEILDSLIRE MRQMGQPCDA YQKRLLQLQE QMRALYKAIS VPRVRRASSK GGGGYTCQSG SGWDEFTKHV TSECLGWMRQ QRAEMDMVAW GVDLASVEQH INSHRGIHNS IGDYRWQLDK IKADLREKSA IYQLEEEYEN LLKASFERMD HLRQLQNIIQ ATSREIMWIN DCEEEELLYD WSD
 OMIM    125647
 3D Structure    ModBase 3D Structure for P15924
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DSP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DSP recombinant protein

   Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
 Product Categories/Family for DSP recombinant protein    Signal Transduction
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 SDS-Page of DSP recombinant protein    DSP recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for DSP. It may not necessarily be applicable to this product.
 NCBI GI #    58530842
 NCBI GeneID    1832
 NCBI Accession #    NP_001008844.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008844.2 [Other Products]
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 UniProt Primary Accession #    P15924 [Other Products]
 UniProt Secondary Accession #    O75993; Q14189; Q9UHN4; B2RTT2; D7RX09 [Other Products]
 UniProt Related Accession #    P15924 [Other Products]
 Molecular Weight    42kD
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 NCBI Official Full Name    desmoplakin isoform II
 NCBI Official Synonym Full Names    desmoplakin
 NCBI Official Symbol    DSP [Similar Products]
 NCBI Official Synonym Symbols   
DP; DCWHKTA
[Similar Products]
 NCBI Protein Information    desmoplakin
 UniProt Protein Name    Desmoplakin
 UniProt Synonym Protein Names   
250/210 kDa paraneoplastic pemphigus antigen
 Protein Family    Desmoplakin
 UniProt Gene Name    DSP [Similar Products]
 UniProt Synonym Gene Names    DP [Similar Products]
 UniProt Entry Name    DESP_HUMAN
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 NCBI Summary for DSP    This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
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 UniProt Comments for DSP    Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
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Product References and Citations for DSP recombinant protein

   Molecular structure of the human desmoplakin I and II amino terminus.Virata M.L.A., Wagner R.M., Parry D.A.D., Green K.J.Proc. Natl. Acad. Sci. U.S.A. 89:544-548(1992) Identification and characterization of DSPIa, a novel isoform of human desmoplakin.Cabral R.M., Wan H., Cole C.L., Abrams D.J., Kelsell D.P., South A.P.Cell Tissue Res. 341:121-129(2010) The DNA sequence and analysis of human chromosome 6.Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.Nature 425:805-811(2003) Structure of the human desmoplakins. Implications for function in the desmosomal plaque.Green K.J., Parry D.A.D., Steinert P.M., Virata M.L.A., Wagner R.M., Angst B.D., Nilles L.A.J. Biol. Chem. 265:2603-2612(1990) ErratumGreen K.J., Parry D.A.D., Steinert P.M., Virata M.L.A., Wagner R.M., Angst B.D., Nilles L.A.J. Biol. Chem. 265:11406-11407(1990) Striate palmoplantar keratoderma resulting from desmoplakin haploinsufficiency.Whittock N.V., Ashton G.H., Dopping-Hepenstal P.J., Gratian M.J., Keane F.M., Eady R.A.J., McGrath J.A.J. Invest. Dermatol. 113:940-946(1999) The amino-terminal domain of desmoplakin binds to plakoglobin and clusters desmosomal cadherin-plakoglobin complexes.Kowalczyk A.P., Bornslaeger E.A., Borgwardt J.E., Palka H.L., Dhaliwal A.S., Corcoran C.M., Denning M.F., Green K.J.J. Cell Biol. 139:773-784(1997) Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope.Marekov L.N., Steinert P.M.J. Biol. Chem. 273:17763-17770(1998) Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma.Armstrong D.K., McKenna K.E., Purkis P.E., Green K.J., Eady R.A.J., Leigh I.M., Hughes A.E.Hum. Mol. Genet. 8:143-148(1999) ErratumArmstrong D.K., McKenna K.E., Purkis P.E., Green K.J., Eady R.A.J., Leigh I.M., Hughes A.E.Hum. Mol. Genet. 8:943-943(1999) Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma.Norgett E.E., Hatsell S.J., Carvajal-Huerta L., Cabezas J.-C.R., Common J., Purkis P.E., Whittock N.V., Leigh I.M., Stevens H.P., Kelsell D.P.Hum. Mol. Genet. 9:2761-2766(2000) Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.Koster J., Geerts D., Favre B., Borradori L., Sonnenberg A.J. Cell Sci. 116:387-399(2003) Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.Fontao L., Favre B., Riou S., Geerts D., Jaunin F., Saurat J.H., Green K.J., Sonnenberg A., Borradori L.Mol. Biol. Cell 14:1978-1992(2003) Early death from cardiomyopathy in a family with autosomal dominant striate palmoplantar keratoderma and woolly hair associated with a novel insertion mutation in desmoplakin.Norgett E.E., Lucke T.W., Bowers B., Munro C.S., Leigh I.M., Kelsell D.P.J. Invest. Dermatol. 126:1651-1654(2006) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. IIIJ. Proteome Res. 7:1346-1351(2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.Mol. Cell 31:438-448(2008) A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) Large-scale proteomics analysis of the human kinome.Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.Mol. Cell. Proteomics 8:1751-1764(2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.Gehmlich K., Syrris P., Peskett E., Evans A., Ehler E., Asimaki A., Anastasakis A., Tsatsopoulou A., Vouliotis A.I., Stefanadis C., Saffitz J.E., Protonotarios N., McKenna W.J.Cardiovasc. Res. 90:77-87(2011) A new hypo/oligodontia syndrome Carvajal/Naxos syndrome secondary to desmoplakin-dominant mutations.Chalabreysse L., Senni F., Bruyere P., Aime B., Ollagnier C., Bozio A., Bouvagnet P.J. Dent. Res. 90:58-64(2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.Sci. Signal. 4:RS3-RS3(2011) Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.Kirchner F., Schuetz A., Boldt L.H., Martens K., Dittmar G., Haverkamp W., Thierfelder L., Heinemann U., Gerull B.Circ. Cardiovasc. Genet. 5:400-411(2012) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.Choi H.J., Park-Snyder S., Pascoe L.T., Green K.J., Weis W.I.Nat. Struct. Biol. 9:612-620(2002) Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain.Choi H.J., Weis W.I.J. Mol. Biol. 409:800-812(2011) Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy.Rampazzo A., Nava A., Malacrida S., Beffagna G., Bauce B., Rossi V., Zimbello R., Simionati B., Basso C., Thiene G., Towbin J.A., Danieli G.A.Am. J. Hum. Genet. 71:1200-1206(2002) Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome.Whittock N.V., Wan H., Morley S.M., Garzon M.C., Kristal L., Hyde P., McLean W.H.I., Pulkkinen L., Uitto J., Christiano A.M., Eady R.A.J., McGrath J.A.J. Invest. Dermatol. 118:232-238(2002) A recessive mutation in desmoplakin causes arrhythmogenic right ventricular dysplasia, skin disorder, and woolly hair.Alcalai R., Metzger S., Rosenheck S., Meiner V., Chajek-Shaul T.J. Am. Coll. Cardiol. 42:319-327(2003) Loss of desmoplakin tail causes lethal acantholytic epidermolysis bullosa.Jonkman M.F., Pasmooij A.M.G., Pasmans S.G.M.A., van den Berg M.P., Ter Horst H.J., Timmer A., Pas H.H.Am. J. Hum. Genet. 77:653-660(2005) Clinical profile of four families with arrhythmogenic right ventricular cardiomyopathy caused by dominant desmoplakin mutations.Bauce B., Basso C., Rampazzo A., Beffagna G., Daliento L., Frigo G., Malacrida S., Settimo L., Danieli G., Thiene G., Nava A.Eur. Heart J. 26:1666-1675(2005) Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy.den Haan A.D., Tan B.Y., Zikusoka M.N., Llado L.I., Jain R., Daly A., Tichnell C., James C., Amat-Alarcon N., Abraham T., Russell S.D., Bluemke D.A., Calkins H., Dalal D., Judge D.P.Circ. Cardiovasc. Genet. 2:428-435(2009) Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia.Barahona-Dussault C., Benito B., Campuzano O., Iglesias A., Leung T.L., Robb L., Talajic M., Brugada R.Clin. Genet. 77:37-48(2010) Expanding the phenotype associated with a desmoplakin dominant mutation Carvajal/Naxos syndrome associated with leukonychia and oligodontia.Boule S., Fressart V., Laux D., Mallet A., Simon F., de Groote P., Bonnet D., Klug D., Charron P.Int. J. Cardiol. 161:50-52(2012) +Additional computationally mapped references.<p>Provides general information on the entry.
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 Research Articles on DSP    1. There is higher incidence of Myocarditis in DSP mutation carriers affected by Arrhythmogenic right ventricular dysplasia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DSP recombinant proteinPathways associated with DSP recombinant protein
 Reference Product  PubMed Publications
 PKP2 recombinant protein  >51 publications with DSP and PKP2
 JUP recombinant protein  >47 publications with DSP and JUP
 DSC2 recombinant protein  >39 publications with DSP and DSC2
 PKP1 recombinant protein  >10 publications with DSP and PKP1
 PKP4 recombinant protein  >5 publications with DSP and PKP4
 PKP3 recombinant protein  >2 publications with DSP and PKP3
 EVPL recombinant protein  >1 publications with DSP and EVPL
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
Diseases associated with DSP recombinant proteinOrgans/Tissues associated with DSP recombinant protein
 Disease Name  Pubmed Publications
 Poisoning Antibodies  >273 publications with DSP and Poisoning
 Cardiovascular Diseases Antibodies  >174 publications with DSP and Cardiovascular Diseases
 Immune System Diseases Antibodies  >154 publications with DSP and Immune System Diseases
 Brain Diseases Antibodies  >97 publications with DSP and Brain Diseases
 Disease Models, Animal Antibodies  >69 publications with DSP and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >61 publications with DSP and Heart Defects, Congenital
 Nerve Degeneration Antibodies  >32 publications with DSP and Nerve Degeneration
 Inflammation Antibodies  >32 publications with DSP and Inflammation
 Necrosis Antibodies  >30 publications with DSP and Necrosis
 Death, Sudden, Cardiac Antibodies  >30 publications with DSP and Death, Sudden, Cardiac
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >603 publications with DSP and Brain
 Heart Antibodies  >217 publications with DSP and Heart
 Mouth Antibodies  >215 publications with DSP and Mouth
 Skin Antibodies  >159 publications with DSP and Skin
 Muscle Antibodies  >143 publications with DSP and Muscle
 Bone Antibodies  >135 publications with DSP and Bone
 Testis Antibodies  >104 publications with DSP and Testis
 Liver Antibodies  >75 publications with DSP and Liver
 Lung Antibodies  >75 publications with DSP and Lung
 Kidney Antibodies  >53 publications with DSP and Kidney
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