NP_001265231.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47.4 kDa
NCBI Official Full Name
diablo homolog, mitochondrial isoform 4
NCBI Official Synonym Full Names
diablo IAP-binding mitochondrial protein
NCBI Official Synonym Symbols
NCBI Protein Information
diablo homolog, mitochondrial
UniProt Protein Name
Diablo homolog, mitochondrial
UniProt Synonym Protein Names
Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac
UniProt Synonym Gene Names
NCBI Summary for DIABLO
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
UniProt Comments for DIABLO
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Research Articles on DIABLO
Precautions
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Products associated with DIABLO recombinant protein
Pathways associated with DIABLO recombinant protein
Diseases associated with DIABLO recombinant protein
Organs/Tissues associated with DIABLO recombinant protein
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