NP_001082.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
amiloride-sensitive amine oxidase
NCBI Official Synonym Full Names
amine oxidase, copper containing 1
NCBI Protein Information
amiloride-sensitive amine oxidase [copper-containing]; amiloride-sensitive amine oxidase [copper-containing]; histaminase; diamine oxidase; kidney amine oxidase; amiloride-binding protein 1; amine oxidase copper domain-containing protein 1; amiloride binding protein 1 (amine oxidase (copper-containing))
UniProt Protein Name
Amiloride-sensitive amine oxidase [copper-containing]
UniProt Synonym Protein Names
Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase
UniProt Synonym Gene Names
UniProt Entry Name
AOC1_HUMAN
NCBI Summary for DAO
This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for DAO
ABP1: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. Belongs to the copper/topaquinone oxidase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.4.3.22; Oxidoreductase; Secreted, signal peptide; Amino Acid Metabolism - tryptophan; Secreted; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: extracellular space; tight junction; plasma membrane; peroxisome
Molecular Function: heparin binding; amine oxidase activity; protein homodimerization activity; copper ion binding; zinc ion binding; protein complex binding; cation channel activity; receptor activity; drug binding; calcium ion binding; sodium channel activity; quinone binding
Biological Process: response to drug; response to antibiotic; amine metabolic process
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Pathways associated with DAO recombinant protein
Diseases associated with DAO recombinant protein
Organs/Tissues associated with DAO recombinant protein
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