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DKK1 recombinant protein :: Dickkopf-Related Protein 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143555 DKK1 recombinant protein
Unit / Price
0.002 mg  /  $245 +1 FREE 8GB USB
0.005 mg  /  $360 +1 FREE 8GB USB
0.01 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dickkopf-Related Protein 1 (DKK1), Recombinant Protein

 Also Known As   

Recombinant Human Dickkopf-Related Protein 1

 Product Synonym Names    DKK1 Human; Dickkopf-Related Protein 1 Human Recombinant; DKK-1; DKK1; HDKK1; HDKK-1; Dickkopf-1; Dickkopf-related protein 1; SK
 Product Gene Name   

DKK1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    ADP TLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRHSG RLVPRGSHHH HHH.
 OMIM    605189
 3D Structure    ModBase 3D Structure for O94907
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 Host    Hi-5 Baculovirus
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 Purity/Purification    Greater than 85.0% as determined by SDS-PAGE.
 Form/Format    The DKK1 protein solution (0.25mg/ml) contains PBS (pH 7.4) and 10% Glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of DKK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DKK1 recombinant protein

   Description: DKK1 produced in Hi-5 is a single, glycosylated polypeptide chain containing 253 amino acids (32-266 a.a.) and having a molecular mass of 27.8 kDa.DKK1 is expressed with a 15 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Introduction: DKK1 is part of the dickkopf family. DKK1 is a secreted protein with 2 cysteine rich regions and takes part in embryonic development through its inhibition of the WNT signaling pathway. High levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. Induction of DKK1 contributes to the pathological cascade triggered by beta-amyloid and is significantly involved in the development of tau phosphorylation. DKK1 reduces the differentiation of osteoblastic precursor cells. DKK1 is an important member in multiple myeloma bone disease. DKK1 expression is reduced in human colon tumors, implying that DKK-1 plays a role as a tumor suppressor gene in this neoplasia; the Wnt/beta-catenin pathway is downregulated by the induction of DKK1 expression, a mechanism that is missing in colon cancer.
 Product Categories/Family for DKK1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Dickkopf-Related Protein
NCBI/Uniprot data below describe general gene information for DKK1. It may not necessarily be applicable to this product.
 NCBI GI #    7110719
 NCBI GeneID    22943
 NCBI Accession #    NP_036374.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012242.2 [Other Products]
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 UniProt Primary Accession #    O94907 [Other Products]
 UniProt Secondary Accession #    B2RC19 [Other Products]
 UniProt Related Accession #    O94907 [Other Products]
 Molecular Weight    28,672 Da
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 NCBI Official Full Name    dickkopf-related protein 1
 NCBI Official Synonym Full Names    dickkopf WNT signaling pathway inhibitor 1
 NCBI Official Symbol    DKK1 [Similar Products]
 NCBI Official Synonym Symbols   
SK; DKK-1
[Similar Products]
 NCBI Protein Information    dickkopf-related protein 1; dickkopf 1 homolog; dickkopf related protein-1; dickkopf-1 like; dickkopf-like protein 1; hDkk-1
 UniProt Protein Name    Dickkopf-related protein 1
 UniProt Synonym Protein Names   
SK
 Protein Family    Dickkopf-related protein
 UniProt Gene Name    DKK1 [Similar Products]
 UniProt Synonym Gene Names    Dickkopf-1; Dkk-1; hDkk-1 [Similar Products]
 UniProt Entry Name    DKK1_HUMAN
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 NCBI Summary for DKK1    This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DKK1    DKK1: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling. Placenta. Belongs to the dickkopf family.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular space; early endosome membrane; plasma membrane; extracellular region

Molecular Function: receptor antagonist activity; protein binding; signal transducer activity; growth factor activity; low-density lipoprotein receptor binding

Biological Process: negative regulation of skeletal muscle development; cellular morphogenesis during differentiation; negative regulation of Wnt receptor signaling pathway; response to retinoic acid; regulation of receptor internalization; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of BMP signaling pathway; negative regulation of mesodermal cell fate specification; hair follicle development; mesoderm formation; endoderm formation; forebrain development; regulation of endodermal cell fate specification; negative regulation of protein complex assembly; embryonic limb morphogenesis
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 Research Articles on DKK1    1. ox-LDL may induce DKK1 expression in macrophages to inhibit the accumulation of lipids through a mechanism that involves downregulation of LOX-1-mediated lipid uptake
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DKK1 recombinant proteinPathways associated with DKK1 recombinant protein
 Reference Product  PubMed Publications
 CTNNB1 recombinant protein  >497 publications with DKK1 and CTNNB1
 WNT3A recombinant protein  >130 publications with DKK1 and WNT3A
 LRP5 recombinant protein  >119 publications with DKK1 and LRP5
 LRP6 recombinant protein  >105 publications with DKK1 and LRP6
 WNT1 recombinant protein  >40 publications with DKK1 and WNT1
 KREMEN1 recombinant protein  >18 publications with DKK1 and KREMEN1
 KREMEN2 recombinant protein  >15 publications with DKK1 and KREMEN2
 RSPO1 recombinant protein  >11 publications with DKK1 and RSPO1
 FZD1 recombinant protein  >10 publications with DKK1 and FZD1
 FZD8 recombinant protein  >4 publications with DKK1 and FZD8
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
Diseases associated with DKK1 recombinant proteinOrgans/Tissues associated with DKK1 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >93 publications with DKK1 and Cardiovascular Diseases
 Hematologic Diseases Antibodies  >71 publications with DKK1 and Hematologic Diseases
 Nervous System Diseases Antibodies  >43 publications with DKK1 and Nervous System Diseases
 Inflammation Antibodies  >42 publications with DKK1 and Inflammation
 Adenocarcinoma Antibodies  >42 publications with DKK1 and Adenocarcinoma
 Brain Diseases Antibodies  >38 publications with DKK1 and Brain Diseases
 Fractures, Bone Antibodies  >36 publications with DKK1 and Fractures, Bone
 Breast Neoplasms Antibodies  >36 publications with DKK1 and Breast Neoplasms
 Necrosis Antibodies  >35 publications with DKK1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >35 publications with DKK1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >486 publications with DKK1 and Bone
 Embryonic Tissue Antibodies  >104 publications with DKK1 and Embryonic Tissue
 Bone Marrow Antibodies  >100 publications with DKK1 and Bone Marrow
 Brain Antibodies  >80 publications with DKK1 and Brain
 Connective Tissue Antibodies  >79 publications with DKK1 and Connective Tissue
 Vascular Antibodies  >58 publications with DKK1 and Vascular
 Liver Antibodies  >53 publications with DKK1 and Liver
 Muscle Antibodies  >50 publications with DKK1 and Muscle
 Skin Antibodies  >49 publications with DKK1 and Skin
 Lung Antibodies  >42 publications with DKK1 and Lung
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