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DKK2 recombinant protein :: Dickkopf-related protein 2 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1341887
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $770 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $920 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,035 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,155 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,160 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,170 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,670 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,760 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,780 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,230 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dickkopf-related protein 2 (DKK2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Dickkopf-related protein 2

 Product Gene Name   

DKK2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    34-259aa; Full Length
 Sequence    KLNSIKSSLG GETPGQAANR SAGMYQGLAF GGSKKGKNLG QAYPCSSDKE CEVGRYCHSP HQGSSACMVC RRKKKRCHRD GMCCPSTRCN NGICIPVTES ILTPHIPALD GTRHRDRNHG HYSNHDLGWQ NLGRPHTKMS HIKGHEGDPC LRSSDCIEGF CCARHFWTKI CKPVLHQGEV CTKQRKKGSH GLEIFQRCDC AKGLSCKVWK DATYSSKARL HVCQKI
 OMIM    605415
 3D Structure    ModBase 3D Structure for Q9UBU2
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DKK2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DKK2 recombinant protein

   Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
 Product Categories/Family for DKK2 recombinant protein    Signal Transduction
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 SDS-PAGE of DKK2 recombinant protein    DKK2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for DKK2. It may not necessarily be applicable to this product.
 NCBI GeneID    27123
 NCBI Accession #    NP_055236.1 [Other Products]
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 UniProt Primary Accession #    Q9UBU2 [Other Products]
 UniProt Secondary Accession #    Q9UIU3; A0AVE9; B2R6S7 [Other Products]
 UniProt Related Accession #    Q9UBU2 [Other Products]
 Molecular Weight    41kD
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 NCBI Official Synonym Full Names    dickkopf WNT signaling pathway inhibitor 2
 NCBI Official Symbol    DKK2 [Similar Products]
 NCBI Official Synonym Symbols   
DKK-2
[Similar Products]
 NCBI Protein Information    dickkopf-related protein 2
 UniProt Protein Name    Dickkopf-related protein 2
 Protein Family    Dickkopf-related protein
 UniProt Gene Name    DKK2 [Similar Products]
 UniProt Synonym Gene Names    Dickkopf-2; Dkk-2; hDkk-2 [Similar Products]
 UniProt Entry Name    DKK2_HUMAN
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 NCBI Summary for DKK2    This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]
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 UniProt Comments for DKK2    DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family.

Protein type: Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: extracellular space

Biological Process: multicellular organismal development; Wnt receptor signaling pathway
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Product References and Citations for DKK2 recombinant protein

   Functional and structural diversity of the human Dickkopf gene family.Krupnik V.E., Sharp J.D., Jiang C., Robison K., Chickering T.W., Amaravadi L., Brown D.E., Guyot D., Mays G., Leiby K., Chang B., Duong T., Goodearl A.D.J., Gearing D.P., Sokol S.Y., McCarthy S.A.Gene 238:301-313(1999) Tanaka S., Sugimachi K., Sugimachi K.The secreted protein discovery initiative (SPDI) , a large-scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment.Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.Genome Res. 13:2265-2270(2003) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004)
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 Research Articles on DKK2    1. MiR-21 overexpression was significantly correlated with the DKK2-/beta-catenin- immunohistochemical phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DKK2 recombinant proteinPathways associated with DKK2 recombinant protein
 Reference Product  PubMed Publications
 DKK1 recombinant protein  >62 publications with DKK2 and DKK1
 DKK3 recombinant protein  >42 publications with DKK2 and DKK3
 LRP6 recombinant protein  >21 publications with DKK2 and LRP6
 LRP5 recombinant protein  >19 publications with DKK2 and LRP5
 WNT6 recombinant protein  >6 publications with DKK2 and WNT6
 WNT7B recombinant protein  >6 publications with DKK2 and WNT7B
 WNT2 recombinant protein  >5 publications with DKK2 and WNT2
 WNT2B recombinant protein  >3 publications with DKK2 and WNT2B
 KREMEN2 recombinant protein  >2 publications with DKK2 and KREMEN2
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies  Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram
 Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway antibodies  Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
Diseases associated with DKK2 recombinant proteinOrgans/Tissues associated with DKK2 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with DKK2 and Inflammation
 Liver Neoplasms Antibodies  >4 publications with DKK2 and Liver Neoplasms
 Liver Diseases Antibodies  >4 publications with DKK2 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with DKK2 and Carcinoma, Hepatocellular
 Neoplasm Invasiveness Antibodies  >4 publications with DKK2 and Neoplasm Invasiveness
 Kidney Diseases Antibodies  >4 publications with DKK2 and Kidney Diseases
 Congenital Abnormalities Antibodies  >4 publications with DKK2 and Congenital Abnormalities
 Cell Transformation, Neoplastic Antibodies  >3 publications with DKK2 and Cell Transformation, Neoplastic
 Fibrosis Antibodies  >3 publications with DKK2 and Fibrosis
 Cardiovascular Diseases Antibodies  >3 publications with DKK2 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >40 publications with DKK2 and Bone
 Embryonic Tissue Antibodies  >14 publications with DKK2 and Embryonic Tissue
 Liver Antibodies  >11 publications with DKK2 and Liver
 Eye Antibodies  >11 publications with DKK2 and Eye
 Vascular Antibodies  >5 publications with DKK2 and Vascular
 Heart Antibodies  >4 publications with DKK2 and Heart
 Uterus Antibodies  >4 publications with DKK2 and Uterus
 Brain Antibodies  >4 publications with DKK2 and Brain
 Lung Antibodies  >3 publications with DKK2 and Lung
 Placenta Antibodies  >1 publications with DKK2 and Placenta
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