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Add To Compare List DHFR recombinant protein :: Dihydrofolate reductase (DHFR) Recombinant Protein Catalog # MBS960228 Unit / Price 0.02 mg (E-Coli) / $690 +1 FREE 8GB USB 0.1 mg (E-Coli) / $825 +1 FREE 8GB USB 0.02 mg (Yeast) / $865 +1 FREE 8GB USB 0.1 mg (Yeast) / $1,010 +1 FREE 8GB USB 0.02 mg (Baculovirus) / $1,110 +1 FREE 8GB USB 0.02 mg (Mammalian-Cell) / $1,345 +1 FREE 8GB USB 1 mg (E-Coli) / $1,460 +1 FREE 8GB USB 0.1 mg (Baculovirus) / $1,545 +1 FREE 8GB USB 1 mg (Yeast) / $1,980 +2 FREE 8GB USB 0.1 mg (Mammalian-Cell) / $2,175 +2 FREE 8GB USB 1 mg (Baculovirus) / $3,040 +3 FREE 8GB USB 0.5 mg (Mammalian-Cell) / $5,810 +7 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Dihydrofolate reductase (DHFR), Recombinant Protein Full Product Name Recombinant Bovine Dihydrofolate reductase (DHFR) Product Gene Name DHFR recombinant protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Positions 2-187, Full length protein Sequence VRPLNCIVAV SQNMGIGKNG DLPWPPLRNE FQYFQRMTTV SSVEGKQNLV IMGRKTWFSI PEKNRPLKDR INIVLSRELK EPPKGAHFLA KSLDDALELI EDPELTNKVD VVWIVGGSSV YKEAMNKPGH VRLFVTRIMQ EFESDAFFPE IDFEKYKLLP EYPGVPLDVQ EEKGIKYKFE VYEKNN 3D Structure ModBase 3D Structure for P00376 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Bovine Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of DHFR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for DHFR recombinant protein Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. NCBI/Uniprot data below describe general gene information for DHFR. It may not necessarily be applicable to this product. NCBI GI # 118150878 NCBI GeneID 508809 NCBI Accession # NP_001071351.1 [Other Products] NCBI GenBank Nucleotide # NM_001077883.1 [Other Products] UniProt Primary Accession # P00376 [Other Products] UniProt Secondary Accession # Q29RI1[Other Products] UniProt Related Accession # P00376[Other Products] Molecular Weight 21,604 Da TOP NCBI Official Full Name dihydrofolate reductase NCBI Official Symbol DHFR [Similar Products] NCBI Protein Information dihydrofolate reductase UniProt Protein Name Dihydrofolate reductase Protein Family Viral dihydrofolate reductase UniProt Gene Name DHFR [Similar Products] TOP TOP UniProt Comments for DHFR Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (). Research Articles on DHFR 1. Hydrogen peroxide down regulates expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase dysfunction. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with DHFR recombinant protein Reference Product PubMed Publications FPGS recombinant protein >51 publications with DHFR and FPGS TYMS recombinant protein >34 publications with DHFR and TYMS MTR recombinant protein >21 publications with DHFR and MTR SHMT1 recombinant protein >11 publications with DHFR and SHMT1 GGH recombinant protein >9 publications with DHFR and GGH SHMT2 recombinant protein >2 publications with DHFR and SHMT2 Pathways associated with DHFR recombinant protein Products by Pathway Pathway Diagram Cell Cycle Pathway antibodies Cell Cycle Pathway Diagram Cell Cycle, Mitotic Pathway antibodies Cell Cycle, Mitotic Pathway Diagram E2F Mediated Regulation Of DNA Replication Pathway antibodies E2F Mediated Regulation Of DNA Replication Pathway Diagram Folate Biosynthesis Pathway antibodies Folate Biosynthesis Pathway Diagram Folate Biosynthesis Pathway antibodies Folate Biosynthesis Pathway Diagram G1/S Transition Pathway antibodies G1/S Transition Pathway Diagram G1/S-Specific Transcription Pathway antibodies G1/S-Specific Transcription Pathway Diagram Metabolism Pathway antibodies Metabolism Pathway Diagram Metabolism Of Folate And Pterines Pathway antibodies Metabolism Of Folate And Pterines Pathway Diagram Metabolism Of Nitric Oxide Pathway antibodies Metabolism Of Nitric Oxide Pathway Diagram Diseases associated with DHFR recombinant protein Disease Name Pubmed Publications Neoplasms Antibodies >405 publications with DHFR and Neoplasms Drug Toxicity Antibodies >141 publications with DHFR and Drug Toxicity Neoplasms, Experimental Antibodies >110 publications with DHFR and Neoplasms, Experimental Carcinoma Antibodies >107 publications with DHFR and Carcinoma Lymphoma Antibodies >55 publications with DHFR and Lymphoma Lung Diseases Antibodies >47 publications with DHFR and Lung Diseases Skin Diseases Antibodies >46 publications with DHFR and Skin Diseases Gastrointestinal Diseases Antibodies >44 publications with DHFR and Gastrointestinal Diseases Nervous System Diseases Antibodies >42 publications with DHFR and Nervous System Diseases Intestinal Diseases Antibodies >39 publications with DHFR and Intestinal Diseases Organs/Tissues associated with DHFR recombinant protein Organ/Tissue Name Pubmed Publications Ovary Antibodies >307 publications with DHFR and Ovary Liver Antibodies >198 publications with DHFR and Liver Kidney Antibodies >40 publications with DHFR and Kidney Brain Antibodies >30 publications with DHFR and Brain Skin Antibodies >22 publications with DHFR and Skin Reticulum Antibodies >13 publications with DHFR and Reticulum Intestine Antibodies >10 publications with DHFR and Intestine Uterus Antibodies >2 publications with DHFR and Uterus Pancreas Antibodies >1 publications with DHFR and Pancreas Mammary Gland Antibodies >1 publications with DHFR and Mammary Gland TOP © 2006-24 MyBioSource.com. 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