NP_064430.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
44.2 kDa
NCBI Official Full Name
dihydroorotate dehydrogenase (quinone), mitochondrial
NCBI Official Synonym Full Names
dihydroorotate dehydrogenase
NCBI Protein Information
dihydroorotate dehydrogenase (quinone), mitochondrial
UniProt Protein Name
Dihydroorotate dehydrogenase (quinone), mitochondrial
UniProt Synonym Protein Names
Dihydroorotate oxidase
UniProt Synonym Gene Names
UniProt Entry Name
PYRD_MOUSE
UniProt Comments for Dhodh
DHODH: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS); also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases. Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
Protein type: Oxidoreductase; Nucleotide Metabolism - pyrimidine; EC 1.3.5.2; Membrane protein, integral; Mitochondrial
Cellular Component: cell soma; cytoplasm; integral to membrane; membrane; mitochondrial inner membrane; mitochondrion; nucleoplasm
Molecular Function: catalytic activity; dihydroorotate dehydrogenase activity; drug binding; FMN binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors; ubiquinone binding
Biological Process: 'de novo' pyrimidine base biosynthetic process; positive regulation of apoptosis; pyrimidine nucleotide biosynthetic process
Research Articles on Dhodh
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Pathways associated with Dhodh recombinant protein
Diseases associated with Dhodh recombinant protein
Organs/Tissues associated with Dhodh recombinant protein
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