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FMO3 recombinant protein :: Dimethylaniline monooxygenase [N-oxide-forming] 3 (FMO3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958701 FMO3 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $955 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,025 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,150 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,280 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,385 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,400 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,410 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,570 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,005 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,090 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,115 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,385 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,750 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dimethylaniline monooxygenase [N-oxide-forming] 3 (FMO3), Recombinant Protein

 Also Known As   

Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 3 (FMO3)

 Product Synonym Names    Dimethylaniline monooxygenase [N-oxide-forming] 3; EC=1.14.13.8; Dimethylaniline oxidase 3; FMO II; FMO form 2; Hepatic flavin-containing monooxygenase 3; FMO 3
 Product Gene Name   

FMO3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-532aa; Full length protein
 Sequence    GKKVAIIGA GVSGLASIRS CLEEGLEPTC FEKSNDIGGL WKFSDHAEEG RASIYKSVFS NSSKEMMCFP DFPFPDDFPN FMHNSKIQEY IIAFAKEKNL LKYIQFKTFV SSVNKHPDFA TTGQWDVTTE RDGKKESAVF DAVMVCSGHH VYPNLPKESF PGLNHFKGKC FHSRDYKEPG VFNGKRVLVV GLGNSGCDIA TELSRTAEQV MISSRSGSWV MSRVWDNGYP WDMLLVTRFG TFLKNNLPTA ISDWLYVKQM NARFKHENYG LMPLNGVLRK EPVFNDELPA SILCGIVSVK PNVKEFTETS AIFEDGTIFE GIDCVIFATG YSFAYPFLDE SIIKSRNNEI ILFKGVFPPL LEKSTIAVIG FVQSLGAAIP TVDLQSRWAA QVIKGTCTLP SMEDMMNDIN EKMEKKRKWF GKSETIQTDY IVYMDELSSF IGAKPNIPWL FLTDPKLAME VYFGPCSPYQ FRLVGPGQWP GARNAILTQW DRSLKPMQTR VVGRLQKPCF FFHWLKLFAI PILLIAVFLV LT
 OMIM    gene 602079
 3D Structure    ModBase 3D Structure for P31513
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of FMO3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for FMO3. It may not necessarily be applicable to this product.
 NCBI GI #    50541961
 NCBI GeneID    2328
 NCBI Accession #    NP_001002294.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002294.2 [Other Products]
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 UniProt Primary Accession #    P31513 [Other Products]
 UniProt Secondary Accession #    Q14854; Q8N5N5; B2R816 [Other Products]
 UniProt Related Accession #    P31513 [Other Products]
 Molecular Weight    60,033 Da
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 NCBI Official Full Name    dimethylaniline monooxygenase
 NCBI Official Synonym Full Names    flavin containing monooxygenase 3
 NCBI Official Symbol    FMO3 [Similar Products]
 NCBI Official Synonym Symbols   
TMAU; FMOII; dJ127D3.1
[Similar Products]
 NCBI Protein Information    dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline monooxygenase [N-oxide-forming] 3; FMO 3; FMO II; FMO form 2; dimethylaniline oxidase 3; trimethylamine monooxygenase; hepatic flavin-containing monooxygenase 3; hepatic flavin-containing monooxygenase-3
 UniProt Protein Name    Dimethylaniline monooxygenase [N-oxide-forming] 3
 UniProt Synonym Protein Names   
Dimethylaniline oxidase 3; FMO II; FMO form 2; Hepatic flavin-containing monooxygenase 3; FMO 3; Trimethylamine monooxygenase (EC:1.14.13.148)
 Protein Family    Dimethylaniline monooxygenase
 UniProt Gene Name    FMO3 [Similar Products]
 UniProt Synonym Gene Names    FMO 3 [Similar Products]
 UniProt Entry Name    FMO3_HUMAN
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 NCBI Summary for FMO3    Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Aug 2009]
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 UniProt Comments for FMO3    FMO3: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds. Defects in FMO3 are the cause of trimethylaminuria (TMAU); also known as fish-odor syndrome. TMAU is an inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino- trimethylamine (TMA) derived from foodstuffs. Such individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. Belongs to the FMO family.

Protein type: Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.13.148; EC 1.14.13.8

Chromosomal Location of Human Ortholog: 1q24.3

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; integral to membrane

Molecular Function: amino acid binding; FAD binding; NADP binding; flavin-containing monooxygenase activity

Biological Process: xenobiotic metabolic process; drug metabolic process

Disease: Trimethylaminuria
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 Research Articles on FMO3    1. FMO3 (rs2266780) was in complete linkage disequilibrium with FMO6.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FMO3 recombinant proteinPathways associated with FMO3 recombinant protein
 Reference Product  PubMed Publications
 CYP3A4 recombinant protein  >42 publications with FMO3 and CYP3A4
 CYP2D6 recombinant protein  >29 publications with FMO3 and CYP2D6
 CYP3A5 recombinant protein  >4 publications with FMO3 and CYP3A5
 CYP2S1 recombinant protein  >1 publications with FMO3 and CYP2S1
 CYP3A7 recombinant protein  >1 publications with FMO3 and CYP3A7
 CYP3A43 recombinant protein  >1 publications with FMO3 and CYP3A43
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Catalytic Cycle Of Mammalian FMOs Pathway antibodies  Catalytic Cycle Of Mammalian FMOs Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 FMO Oxidizes Nucleophiles Pathway antibodies  FMO Oxidizes Nucleophiles Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Nicotine Metabolism Pathway antibodies  Nicotine Metabolism Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Tamoxifen Metabolism Pathway antibodies  Tamoxifen Metabolism Pathway Diagram
Diseases associated with FMO3 recombinant proteinOrgans/Tissues associated with FMO3 recombinant protein
 Disease Name  Pubmed Publications
 Trimethylaminuria Antibodies  >64 publications with FMO3 and Trimethylaminuria
 Drug Toxicity Antibodies  >54 publications with FMO3 and Drug Toxicity
 Liver Diseases Antibodies  >24 publications with FMO3 and Liver Diseases
 Neoplasms Antibodies  >13 publications with FMO3 and Neoplasms
 Nervous System Diseases Antibodies  >11 publications with FMO3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >10 publications with FMO3 and Disease Models, Animal
 Necrosis Antibodies  >7 publications with FMO3 and Necrosis
 Drug-Induced Liver Injury Antibodies  >7 publications with FMO3 and Drug-Induced Liver Injury
 Hypertension Antibodies  >6 publications with FMO3 and Hypertension
 Brain Diseases Antibodies  >6 publications with FMO3 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >416 publications with FMO3 and Liver
 Lung Antibodies  >94 publications with FMO3 and Lung
 Kidney Antibodies  >76 publications with FMO3 and Kidney
 Brain Antibodies  >36 publications with FMO3 and Brain
 Heart Antibodies  >7 publications with FMO3 and Heart
 Skin Antibodies  >3 publications with FMO3 and Skin
 Thyroid Antibodies  >3 publications with FMO3 and Thyroid
 Bone Antibodies  >1 publications with FMO3 and Bone
 Trachea Antibodies  >1 publications with FMO3 and Trachea
 Mammary Gland Antibodies  >1 publications with FMO3 and Mammary Gland
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