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Dab1 recombinant protein :: Disabled homolog 1 (Dab1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS961841 Dab1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,010 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,070 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,195 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,360 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,445 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,450 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,505 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,520 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,645 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,140 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,170 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,180 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,500 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,850 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Disabled homolog 1 (Dab1), Recombinant Protein

 Also Known As   

Recombinant Mouse Disabled homolog 1 (Dab1)

 Product Synonym Names    Disabled homolog 1
 Product Gene Name   

Dab1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-588aa; Full length protein
 Sequence    MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPN SQPLEDFESR FAAATPNRNL SMDFDELLEA TKVSAVTQLE LFGDMSTPPD ITSPPTPATP GDAFLPSSSQ TLPGSADVFG SMSFGTAAVP SGYVAMGAVL PSFWGQQPLV QQQIAMGAQP PVAQVIPGAQ PIAWGQPGLF PATQQAWPTV AGQFPPAAFM PTQTVMPLAA AMFQGPLTPL ATVPGTNDSA RSSPQSDKPR QKMGKESFKD FQMVQPPPVP SRKPDQPSLT CTSEAFSSYF NKVGVAQDTD DCDDFDISQL NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHVSDPTADD IFEEGFESPS KSEEQEAPDG SQASSTSDPF GEPSGEPSGD NISPQDGS
 3D Structure    ModBase 3D Structure for P97318
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Dab1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Dab1 recombinant protein

   The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and This protein is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
NCBI/Uniprot data below describe general gene information for Dab1. It may not necessarily be applicable to this product.
 NCBI GI #    6753596
 NCBI GeneID    13131
 NCBI Accession #    NP_034144.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010014.3 [Other Products]
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 UniProt Primary Accession #    P97318 [Other Products]
 UniProt Secondary Accession #    P97316; P97317; Q9DAP9; A2A963; A2A964; A2A965; A2A966; A2A967; A2A970 [Other Products]
 UniProt Related Accession #    P97318 [Other Products]
 Molecular Weight    59,838 Da
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 NCBI Official Full Name    disabled homolog 1 isoform 1
 NCBI Official Synonym Full Names    disabled 1
 NCBI Official Symbol    Dab1 [Similar Products]
 NCBI Official Synonym Symbols   
scm; scr; yot; AI956902; scrambler; C630028C02Rik
[Similar Products]
 NCBI Protein Information    disabled homolog 1; yotari
 UniProt Protein Name    Disabled homolog 1
 Protein Family    Disabled
 UniProt Gene Name    Dab1 [Similar Products]
 UniProt Entry Name    DAB1_MOUSE
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 UniProt Comments for Dab1    DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons

Protein type: Adaptor/scaffold

Cellular Component: neuron projection; membrane; cell soma; perinuclear region of cytoplasm; apical part of cell; postsynaptic density; intracellular; cytosol; brush border

Molecular Function: protein binding; phospholipid binding; phosphoinositide 3-kinase binding; SH2 domain binding

Biological Process: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; nervous system development; central nervous system development; cerebellum structural organization; Golgi localization; multicellular organismal development; neuron migration; negative regulation of cell adhesion; adult walking behavior; cerebral cortex cell migration; small GTPase mediated signal transduction; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; negative regulation of astrocyte differentiation; dendrite development; negative regulation of axonogenesis; cerebral cortex radially oriented cell migration; cell differentiation; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade
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 Research Articles on Dab1    1. The results of this study indicate a causal relation between the downregulation of Dab1 protein levels during development and the structural and behavioral deficits associated with psychiatric diseases in the adult.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Dab1 recombinant proteinPathways associated with Dab1 recombinant protein
 Reference Product  PubMed Publications
 Vldlr recombinant protein  >58 publications with Dab1 and Vldlr
 App recombinant protein  >19 publications with Dab1 and App
 Lrp8 recombinant protein  >7 publications with Dab1 and Lrp8
 Ldlr recombinant protein  >3 publications with Dab1 and Ldlr
 Aplp2 recombinant protein  >3 publications with Dab1 and Aplp2
 Aplp1 recombinant protein  >3 publications with Dab1 and Aplp1
 Lrp1 recombinant protein  >1 publications with Dab1 and Lrp1
 Products by Pathway  Pathway Diagram
 Splicing Factor NOVA Regulated Synpatic Proteins Pathway antibodies  Splicing Factor NOVA Regulated Synpatic Proteins Pathway Diagram
Diseases associated with Dab1 recombinant proteinOrgans/Tissues associated with Dab1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >36 publications with Dab1 and Nervous System Diseases
 Movement Disorders Antibodies  >11 publications with Dab1 and Movement Disorders
 Disease Models, Animal Antibodies  >6 publications with Dab1 and Disease Models, Animal
 Pain Antibodies  >3 publications with Dab1 and Pain
 Inflammation Antibodies  >2 publications with Dab1 and Inflammation
 Mood Disorders Antibodies  >2 publications with Dab1 and Mood Disorders
 Nerve Degeneration Antibodies  >2 publications with Dab1 and Nerve Degeneration
 Abnormalities, Drug-Induced Antibodies  >2 publications with Dab1 and Abnormalities, Drug-Induced
 Autistic Disorder Antibodies  >2 publications with Dab1 and Autistic Disorder
 Memory Disorders Antibodies  >1 publications with Dab1 and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >248 publications with Dab1 and Brain
 Embryonic Tissue Antibodies  >79 publications with Dab1 and Embryonic Tissue
 Spinal Cord Antibodies  >15 publications with Dab1 and Spinal Cord
 Eye Antibodies  >15 publications with Dab1 and Eye
 Kidney Antibodies  >6 publications with Dab1 and Kidney
 Intestine Antibodies  >6 publications with Dab1 and Intestine
 Spleen Antibodies  >3 publications with Dab1 and Spleen
 Ovary Antibodies  >1 publications with Dab1 and Ovary
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