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Dab2 recombinant protein :: Disabled homolog 2 (Dab2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958698 Dab2 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,200 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,335 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,585 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,620 +2 FREE 8GB USB
0.2 mg (Yeast)  /  $1,655 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,695 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,790 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,875 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,380 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,415 +3 FREE 8GB USB
1 mg (E-Coli)  /  $2,525 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,830 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,160 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Disabled homolog 2 (Dab2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Disabled homolog 2 (Dab2)

 Product Gene Name   

Dab2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-766aa, Full Length of Mature Protein
 Sequence    SNEVETSTTN GQPDQQAAPK APSKKEKKKG SEKTDEYLLA RFKGDGVKYK AKLIGIDDVP DARGDKMSQD SMMKLKGMAA AGRSQGQHKQ RIWVNISLSG IKIIDEKTGV IEHEHPVNKI SFIARDVTDN RAFGYVCGGE GQHQFFAIKT GQQAEPLVVD LKDLFQVIYN VKKKEEDKKK VEEANKAEEN GSEALMTLDD QANKLKLGVD QMDLFGDMST PPDLNSPTES KDILLVDLNS EIDTNQNSLR ENPFLTNGVT SCSLPRPKPQ ASFLPENAFS ANLNFFPTPN PDPFRDDPFA QPDQSAPSSF DSLTSPDQKK ASLSSSSTPQ SKGPLNGDTD YFGQQFDQLS NRTGKPEAQG GPWPYPSSQT QQAVRTQNGV SEREQNGFHI KSSPNPFVGS PPKGLSVPNG VKQDLESSVQ SSAHDSIAII PPPQSTKPGR GRRTAKSSAN DLLASDIFAS EPPGQMSPTG QPAVPQSNFL DLFKGNAPAP VGPLVGLGTV PVTPPQAGPW TPVVYSPSTT VVPGAIISGQ PPSFRQPLVF GTTPAVQVWN QSPSFATPAS PPPPTVWCPT TSVAPNAWSS TSPLGNPFQS NNIFPPPTMS TQSSPQPMMS SVLATPPQPP PRNGPLKDIP SDAFTGLDPL GDKEVKEVKE MFKDFQLRQP PLVPSRKGET PPSGTSSAFS SYFNNKVGIP QEHVDHDDFD ANQLLNKINE PPKPAPRQGV LLGTKSADNS LENPFSKGFS SSNPSVVSQP ASSDPHRSPF GNPFA
 3D Structure    ModBase 3D Structure for P98078
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Dab2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Dab2 recombinant protein

   DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).
NCBI/Uniprot data below describe general gene information for Dab2. It may not necessarily be applicable to this product.
 NCBI GI #    56785430
 NCBI GeneID    13132
 NCBI Accession #    NP_001008702.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008702.2 [Other Products]
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 UniProt Primary Accession #    P98078 [Other Products]
 UniProt Secondary Accession #    Q3U3K1; Q91W56; Q923E1 [Other Products]
 UniProt Related Accession #    P98078 [Other Products]
 Molecular Weight    58,822 Da
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 NCBI Official Full Name    disabled homolog 2 isoform b
 NCBI Official Synonym Full Names    disabled 2, mitogen-responsive phosphoprotein
 NCBI Official Symbol    Dab2 [Similar Products]
 NCBI Official Synonym Symbols   
p96; Doc2; Doc-2; AA960054; AI957090; D15Wsu122e; 5730435J12Rik; D630005B22Rik
[Similar Products]
 NCBI Protein Information    disabled homolog 2
 UniProt Protein Name    Disabled homolog 2
 UniProt Synonym Protein Names   
Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; DOC-2; Mitogen-responsive phosphoprotein
 Protein Family    Disabled
 UniProt Gene Name    Dab2 [Similar Products]
 UniProt Synonym Gene Names    Doc2; DOC-2 [Similar Products]
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 UniProt Comments for Dab2    Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Isoform p96 is involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Isoform p67 is not involved in LDL receptor endocytosis. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. Isoform p67 may be involved in transcriptional regulation. May act as a tumor suppressor.
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 Research Articles on Dab2    1. The various novel mechanisms are described by which Dab2 mediates an array of signaling events with vast physiological consequences.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Dab2 recombinant proteinPathways associated with Dab2 recombinant protein
 Reference Product  PubMed Publications
 Lrp1 recombinant protein  >1 publications with Dab2 and Lrp1
 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Formation Of Annular Gap Junctions Pathway antibodies  Formation Of Annular Gap Junctions Pathway Diagram
 Gap Junction Degradation Pathway antibodies  Gap Junction Degradation Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram
 Gap Junction Trafficking And Regulation Pathway antibodies  Gap Junction Trafficking And Regulation Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
Diseases associated with Dab2 recombinant proteinOrgans/Tissues associated with Dab2 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >70 publications with Dab2 and Neoplasms
 Carcinoma Antibodies  >42 publications with Dab2 and Carcinoma
 Ovarian Neoplasms Antibodies  >25 publications with Dab2 and Ovarian Neoplasms
 Genital Neoplasms, Female Antibodies  >19 publications with Dab2 and Genital Neoplasms, Female
 Adenocarcinoma Antibodies  >13 publications with Dab2 and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >12 publications with Dab2 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >12 publications with Dab2 and Prostatic Diseases
 Breast Neoplasms Antibodies  >11 publications with Dab2 and Breast Neoplasms
 Kidney Diseases Antibodies  >10 publications with Dab2 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >8 publications with Dab2 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >34 publications with Dab2 and Other
 Kidney Antibodies  >23 publications with Dab2 and Kidney
 Blood Antibodies  >15 publications with Dab2 and Blood
 Embryonic Tissue Antibodies  >11 publications with Dab2 and Embryonic Tissue
 Brain Antibodies  >10 publications with Dab2 and Brain
 Lung Antibodies  >9 publications with Dab2 and Lung
 Liver Antibodies  >8 publications with Dab2 and Liver
 Ovary Antibodies  >5 publications with Dab2 and Ovary
 Adrenal Gland Antibodies  >4 publications with Dab2 and Adrenal Gland
 Bladder Antibodies  >4 publications with Dab2 and Bladder
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