NP_036831.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
25,717 Da
NCBI Official Full Name
dnaJ homolog subfamily B member 9
NCBI Official Synonym Full Names
DnaJ heat shock protein family (Hsp40) member B9
NCBI Official Synonym Symbols
NCBI Protein Information
dnaJ homolog subfamily B member 9
UniProt Protein Name
DnaJ homolog subfamily B member 9
UniProt Synonym Protein Names
Endoplasmic reticulum DNA J domain-containing protein 4
UniProt Synonym Gene Names
NCBI Summary for Dnajb9
mammalian chaperone; involved in the control of cell cycle arrest taking place during terminal cell differentiation and under stress conditions [RGD, Feb 2006]
UniProt Comments for Dnajb9
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production ().
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Products associated with Dnajb9 recombinant protein
Pathways associated with Dnajb9 recombinant protein
Diseases associated with Dnajb9 recombinant protein
Organs/Tissues associated with Dnajb9 recombinant protein
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