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Mre11a recombinant protein :: Double-strand break repair protein MRE11A (Mre11a) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1412512 Mre11a recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,135 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,170 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,530 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,540 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,585 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,635 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,690 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $1,795 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,315 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,335 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,405 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,715 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $3,055 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Double-strand break repair protein MRE11A (Mre11a), Recombinant Protein

 Also Known As   

Recombinant Rat Double-strand break repair protein MRE11A (Mre11a)

 Product Synonym Names    Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
 Product Gene Name   

Mre11a recombinant protein

[Similar Products]
 Product Synonym Gene Name    Mre11a; Mre11 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-706aa; full length protein
 Sequence    SPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEIISDQSVN FGFSKFPWVN YRDGNLNISI PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL VIWGHEHECK IGPTRNEQQL FYVSQPGSSV VTALSPGETV KKHVGLLRVK GRKMNMQKLP LRTVRQFFME DVVLANHPSL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPEK PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGKLIIK PASEGTTLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSENAASA FSADDLSFDI TEQTADDSDD SQSAVPSRGR GRGRGRRGGR GQSTAPRGGS QRGRDTGLGI STRGRSSKAT ASTSRNMSII DAFRSTRQQP SRNVATKNYS ETIEVDESDD DDSFPTSSRA DQRWSGTAPS KRMSQSQTAK GVDFESDEDD DDDPFMSGSC PRRNRR
 3D Structure    ModBase 3D Structure for Q9JIM0
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Mre11a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Mre11a recombinant protein

   This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3 to 5 exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3 to 5 exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
NCBI/Uniprot data below describe general gene information for Mre11a. It may not necessarily be applicable to this product.
 NCBI GI #    11560107
 NCBI GeneID    64046
 NCBI Accession #    NP_071615.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022279.1 [Other Products]
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 UniProt Primary Accession #    Q9JIM0 [Other Products]
 UniProt Related Accession #    Q9JIM0 [Other Products]
 Molecular Weight    80,122 Da
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 NCBI Official Full Name    double-strand break repair protein MRE11A
 NCBI Official Synonym Full Names    MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
 NCBI Official Symbol    Mre11a [Similar Products]
 NCBI Official Synonym Symbols   
Mre11
[Similar Products]
 NCBI Protein Information    double-strand break repair protein MRE11A; MRE11 homolog 1; MRE11 homolog A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A
 UniProt Protein Name    Double-strand break repair protein MRE11A
 UniProt Synonym Protein Names   
Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
 Protein Family    Double-strand break repair protein
 UniProt Gene Name    Mre11a [Similar Products]
 UniProt Synonym Gene Names    Mre11; MRE11 homolog 1; MRE11 homolog A [Similar Products]
 UniProt Entry Name    MRE11_RAT
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 NCBI Summary for Mre11a    may play a role in regulation of cardiomyocyte proliferation [RGD, Feb 2006]
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 UniProt Comments for Mre11a    MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: DNA-binding; Deoxyribonuclease; DNA repair, damage; Cell cycle regulation

Cellular Component: nucleoplasm; chromosome, telomeric region; condensed nuclear chromosome; Mre11 complex; perinuclear region of cytoplasm; nuclear chromatin; nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; DNA binding; manganese ion binding; endonuclease activity; exonuclease activity; 3'-5' exonuclease activity

Biological Process: negative regulation of virion penetration into host cell; heart development; positive regulation of kinase activity; sister chromatid cohesion; negative regulation of DNA endoreduplication; positive regulation of protein amino acid autophosphorylation; chromosome organization and biogenesis; DNA duplex unwinding; cell proliferation; meiotic cell cycle; base-excision repair; nucleotide-excision repair; intra-S DNA damage checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; double-strand break repair; synapsis; response to DNA damage stimulus; telomere maintenance
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Mre11a recombinant proteinPathways associated with Mre11a recombinant protein
 Reference Product  PubMed Publications
 Rad50 recombinant protein  >300 publications with Mre11a and Rad50
 Nbn recombinant protein  >213 publications with Mre11a and Nbn
 Atm recombinant protein  >184 publications with Mre11a and Atm
 Brca1 recombinant protein  >55 publications with Mre11a and Brca1
 Mdc1 recombinant protein  >27 publications with Mre11a and Mdc1
 Rbbp8 recombinant protein  >21 publications with Mre11a and Rbbp8
 Exo1 recombinant protein  >8 publications with Mre11a and Exo1
 Fancd2 recombinant protein  >8 publications with Mre11a and Fancd2
 Prmt1 recombinant protein  >6 publications with Mre11a and Prmt1
 Xrcc6 recombinant protein  >2 publications with Mre11a and Xrcc6
 Products by Pathway  Pathway Diagram
 Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway antibodies  Assembly Of The RAD50-MRE11-NBS1 Complex At DNA Double-strand Breaks Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Damage/Telomere Stress Induced Senescence Pathway antibodies  DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
Diseases associated with Mre11a recombinant proteinOrgans/Tissues associated with Mre11a recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >33 publications with Mre11a and Breast Neoplasms
 Congenital Abnormalities Antibodies  >13 publications with Mre11a and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >13 publications with Mre11a and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >12 publications with Mre11a and Ovarian Neoplasms
 Anemia Antibodies  >12 publications with Mre11a and Anemia
 Colonic Neoplasms Antibodies  >9 publications with Mre11a and Colonic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >9 publications with Mre11a and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >9 publications with Mre11a and Carcinoma, Squamous Cell
 ATAXIA-TELANGIECTASIA-LIKE DISORDER 1 Antibodies  >8 publications with Mre11a and ATAXIA-TELANGIECTASIA-LIKE DISORDER 1
 Neurodegenerative Diseases Antibodies  >7 publications with Mre11a and Neurodegenerative Diseases
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >8 publications with Mre11a and Prostate
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