NP_031738.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,987 Da
NCBI Official Full Name
dual specificity protein kinase CLK2 isoform 1
NCBI Official Synonym Full Names
CDC-like kinase 2
NCBI Official Synonym Symbols
NCBI Protein Information
dual specificity protein kinase CLK2
UniProt Protein Name
Dual specificity protein kinase CLK2
UniProt Synonym Protein Names
CDC-like kinase 2
UniProt Comments for Clk2
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Research Articles on Clk2
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Pathways associated with Clk2 recombinant protein
Diseases associated with Clk2 recombinant protein
Organs/Tissues associated with Clk2 recombinant protein
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