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DCTN1 recombinant protein :: Dynactin subunit 1 (DCTN1), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1457410
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $745 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $995 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,095 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Dynactin subunit 1 (DCTN1), partial, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Dynactin subunit 1 (DCTN1), partial

 Product Synonym Names    Dynactin subunit 1; 150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued
 Product Gene Name   

DCTN1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1457410 COA    COA PDF
 MBS1457410 MSDS    MSDS PDF
 Sequence Positions    213-547aa; Partial
 Sequence    PSKEEEGLRA QVRDLEEKLE TLRLKRAEDK AKLKELEKHK IQLEQVQEWK SKMQEQQADL QRRLKEARKE AKEALEAKER YMEEMADTAD AIEMATLDKE MAEERAESLQ QEVEALKERV DELTTDLEIL KAEIEEKGSD GAASSYQLKQ LEEQNARLKD ALVRMRDLSS SEKQEHVKLQ KLMEKKNQEL EVVRQQRERL QEELSQAEST IDELKEQVDA ALGAEEMVEM LTDRNLNLEE KVRELRETVG DLEAMNEMND ELQENARETE LELREQLDMA GARVREAQKR VEAAQETVAD YQQTIKKYRQ LTAHLQDVNR ELTNQQEASV ERQQQ
 OMIM    gene 607641
 3D Structure    ModBase 3D Structure for Q14203
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of DCTN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DCTN1 recombinant protein

   Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
 Product Categories/Family for DCTN1 recombinant protein    Cell Biology
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 SDS-Page of DCTN1 recombinant protein    DCTN1 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for DCTN1. It may not necessarily be applicable to this product.
 NCBI GI #    205277392
 NCBI GeneID    1639
 NCBI Accession #    NP_001128512.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135040.2 [Other Products]
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 UniProt Primary Accession #    Q14203 [Other Products]
 UniProt Secondary Accession #    O95296; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2; A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4 [Other Products]
 UniProt Related Accession #    Q14203 [Other Products]
 Molecular Weight    140,887 Da
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 NCBI Official Full Name    dynactin subunit 1 isoform 3
 NCBI Official Synonym Full Names    dynactin 1
 NCBI Official Symbol    DCTN1 [Similar Products]
 NCBI Official Synonym Symbols   
P135; DP-150; DAP-150
[Similar Products]
 NCBI Protein Information    dynactin subunit 1; 150 kDa dynein-associated polypeptide; dynactin 1 (p150, glued homolog, Drosophila)
 UniProt Protein Name    Dynactin subunit 1
 UniProt Synonym Protein Names   
150 kDa dynein-associated polypeptide; DAP-150; DP-150; p135; p150-glued
 Protein Family    Dynactin
 UniProt Gene Name    DCTN1 [Similar Products]
 UniProt Synonym Gene Names    DP-150 [Similar Products]
 UniProt Entry Name    DCTN1_HUMAN
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 NCBI Summary for DCTN1    This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]
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 UniProt Comments for DCTN1    dynactin 1: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles. Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors. Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally. Belongs to the dynactin 150 kDa subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: kinetochore; spindle pole; dynein complex; centrosome; microtubule; dynactin complex; membrane; retromer complex; leading edge; cytoplasm; cytosol

Molecular Function: dynein binding; protein binding; motor activity

Biological Process: mitosis; nervous system development; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; organelle organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic cell cycle; G2/M transition of mitotic cell cycle; melanosome transport; retrograde transport, endosome to Golgi

Disease: Amyotrophic Lateral Sclerosis 1; Perry Syndrome; Neuronopathy, Distal Hereditary Motor, Type Viib
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 Research Articles on DCTN1    1. The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizing functions of dynactin are distinctly divided between the two isoforms
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DCTN1 recombinant proteinPathways associated with DCTN1 recombinant protein
 Reference Product  PubMed Publications
 DYNC1H1 recombinant protein  >1 publications with DCTN1 and DYNC1H1
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with DCTN1 recombinant proteinOrgans/Tissues associated with DCTN1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >28 publications with DCTN1 and Nervous System Diseases
 Movement Disorders Antibodies  >7 publications with DCTN1 and Movement Disorders
 Parkinsonian Disorders Antibodies  >7 publications with DCTN1 and Parkinsonian Disorders
 Perry Syndrome Antibodies  >6 publications with DCTN1 and Perry Syndrome
 Death Antibodies  >5 publications with DCTN1 and Death
 Weight Loss Antibodies  >4 publications with DCTN1 and Weight Loss
 Hypoventilation Antibodies  >4 publications with DCTN1 and Hypoventilation
 Inflammation Antibodies  >1 publications with DCTN1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with DCTN1 and Brain
 Nerve Antibodies  >8 publications with DCTN1 and Nerve
 Spinal Cord Antibodies  >5 publications with DCTN1 and Spinal Cord
 Muscle Antibodies  >2 publications with DCTN1 and Muscle
 Vascular Antibodies  >1 publications with DCTN1 and Vascular
 Epididymis Antibodies  >1 publications with DCTN1 and Epididymis
 Ovary Antibodies  >1 publications with DCTN1 and Ovary
 Blood Antibodies  >1 publications with DCTN1 and Blood
 Ganglia Antibodies  >1 publications with DCTN1 and Ganglia
 Skin Antibodies  >1 publications with DCTN1 and Skin
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