NP_033994.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,256 Da
NCBI Official Full Name
cadherin-1 preproprotein
NCBI Official Synonym Full Names
cadherin 1
NCBI Official Synonym Symbols
Um; UVO; Ecad; ARC-1; E-cad; L-CAM; AA960649 [Similar Products]
NCBI Protein Information
cadherin-1
UniProt Protein Name
Cadherin-1
UniProt Synonym Protein Names
ARC-1; Epithelial cadherin; E-cadherin
UniProt Synonym Gene Names
NCBI Summary for E-cad
This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]
UniProt Comments for E-cad
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 ().
Research Articles on E-cad
Precautions
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Products associated with E-cad recombinant protein
Pathways associated with E-cad recombinant protein
Diseases associated with E-cad recombinant protein
Organs/Tissues associated with E-cad recombinant protein
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